Comment“Asymptomatic small intestinal ulcerative lesions:Obesity and Helicobacter pylori are likely to be risk factors”

There are many causes of anemia.It is unreasonable to simply associate anemia with asymptomatic ulcers in the small intestine.

Electroconvulsive therapy plays an irreplaceable role in treatment of major depressive disorder

Major depressive disorder is a serious and common neuropsychiatric disorder that affects more than 350 million people worldwide.Electroconvulsive therapy is the oldest and most effective treatment available for the treatment of severe major depressive disorder.Electroconvulsive therapy modifies structural network changes in patients with major depressive disorder and schizophrenia.And it can also affect neuroinflammatory responses and may have neuroprotective effects.Electroconvulsive therapy plays an irreplaceable role in the treatment of major depressive disorder.

Inhibition of glutathione metabolism can limit the development of pancreatic cancer

Pharmacological inhibitors of glutathione synthesis and circulation,such as buthionine-sulfoximine,inhibit glutathione metabolism.These drugs decrease the aggressiveness of pancreatic cancer,inhibit tumor stem cell survival,and reduce chemotherapy resistance.Nevertheless,buthionine-sulfoximine also decreases the content of glutathione in normal cells,disrupts the balance between reactive oxygen species and glutathione,and eventually induces cell apoptosis.Pancreatic cancer is usually diagnosed at an advanced stage and has a poor prognosis.Consequently,the use of biomarkers to screen high-risk patients can be an effective method.

Evaluation of a new frequency-volume chart for children with primary monosymptomatic nocturnal enuresis:a prospective,comparative study

Introduction To improve compliance with voiding diaries in children with primary monosymptomatic nocturnal enuresis(PMNE),a new modified 3-day weekend frequency-volume chart(FVC)was designed,and the compliance and validity of this modified FVC was evaluated by comparing with the International Children's Continence Society(ICCS)recommended voiding diary.Methods A total of 1200 patients with PMNE were enrolled in the study from 13 centers in China and were randomly assigned to record this modified FVC or the ICCS-recommended voiding diary.The primary outcome measure was the compliance,assessed by comparing the completing index and the quality score of diaries between two groups.The secondary outcome measure was the validity,evaluated by comparing the constituent of subtypes,micturition parameters and response rate to desmopressin.Results Among the 1200 participants enrolled in the study,447 patients completed the ICCS-recommended voiding diary and 469 completed the modified diary.The diurnal completing index and the quality score of the modified FVC group were better than those of the ICCS group.In addition,there was no significant difference between these two groups in the subtype classification,or in the response rate to desmopressin.Conclusions The modified FVC could be applied to obtain the voiding characteristics of children with PMNE as the ICCS-recommended voiding diary does and offers a reasonable and better choice for children with PMNE from the unselected population in the future.