In this study, we investigated the effects of adenovirus-mediated transfection of PC12 cells with glucose transporter 3 after ischemic injury. The results of flow cytometry and TUNEL showed that exogenous glucose tran...In this study, we investigated the effects of adenovirus-mediated transfection of PC12 cells with glucose transporter 3 after ischemic injury. The results of flow cytometry and TUNEL showed that exogenous glucose transporter 3 significantly suppressed PC12 cell apoptosis induced by ischemic injury. The results of isotopic scintiscan and western blot assays showed that, the glucose uptake rate was significantly increased and nuclear factor kappaB expression was significantly decreased after adenovirus-mediated transfection of ischemic PC12 cells with glucose transporter 3. These results suggest that adenovirus-mediated transfection of cells with glucose transporter 3 elevates the energy metabolism of PC12 cells with ischemic injury, and inhibits cell apoptosis.展开更多
Data-intensive computing is expected to be the next-generation IT computing paradigm. Data-intensive workflows in clouds are becoming more and more popular. How to schedule data-intensive workflow efficiently has beco...Data-intensive computing is expected to be the next-generation IT computing paradigm. Data-intensive workflows in clouds are becoming more and more popular. How to schedule data-intensive workflow efficiently has become the key issue. In this paper, first, we build a directed hypergraph model for data-intensive workflow, since Hypergraphs can more accurately model communication volume and better represent asymmetric problems, and the cut metric of hypergraphs is well suited for minimizing the total volume of communication.Second, we propose a concept data supportive ability to help the presentation of data-intensive workflow application and provide the merge operation details considering the data supportive ability. Third, we present an optimized hypergraph multi-level partitioning algorithm. Finally we bring a data reduced scheduling policy HEFT-P for data-intensive workflow. Through simulation,we compare HEFT-P with three typical workflow scheduling policies.The results indicate that HEFT-P could obtain reduced data scheduling and reduce the makespan of executing data-intensive展开更多
基金funded by the National Natural Science Foundation of China,No. 30770765
文摘In this study, we investigated the effects of adenovirus-mediated transfection of PC12 cells with glucose transporter 3 after ischemic injury. The results of flow cytometry and TUNEL showed that exogenous glucose transporter 3 significantly suppressed PC12 cell apoptosis induced by ischemic injury. The results of isotopic scintiscan and western blot assays showed that, the glucose uptake rate was significantly increased and nuclear factor kappaB expression was significantly decreased after adenovirus-mediated transfection of ischemic PC12 cells with glucose transporter 3. These results suggest that adenovirus-mediated transfection of cells with glucose transporter 3 elevates the energy metabolism of PC12 cells with ischemic injury, and inhibits cell apoptosis.
文摘Data-intensive computing is expected to be the next-generation IT computing paradigm. Data-intensive workflows in clouds are becoming more and more popular. How to schedule data-intensive workflow efficiently has become the key issue. In this paper, first, we build a directed hypergraph model for data-intensive workflow, since Hypergraphs can more accurately model communication volume and better represent asymmetric problems, and the cut metric of hypergraphs is well suited for minimizing the total volume of communication.Second, we propose a concept data supportive ability to help the presentation of data-intensive workflow application and provide the merge operation details considering the data supportive ability. Third, we present an optimized hypergraph multi-level partitioning algorithm. Finally we bring a data reduced scheduling policy HEFT-P for data-intensive workflow. Through simulation,we compare HEFT-P with three typical workflow scheduling policies.The results indicate that HEFT-P could obtain reduced data scheduling and reduce the makespan of executing data-intensive
