Objective:To analyze the components and mechanisms of Wuyao(Linderae Radix)in treating diabetic nephropathy(DN)based on network pharmacology.Methods:Multiple online databases were used to search and screen out the act...Objective:To analyze the components and mechanisms of Wuyao(Linderae Radix)in treating diabetic nephropathy(DN)based on network pharmacology.Methods:Multiple online databases were used to search and screen out the active ingredients from Linderae Radix,the related targets of active components of Linderae Radix and the genes related to DN.Search the corresponding genes name of target through UniProt database.Cytoscape 3.2.1 was used to construct the corresponding target gene network of Linderae Radix compounds.Venn diagram was used to screen the intersection genes of the active components corresponding to the target and disease-related genes,and the intersection genes were constructed into the protein interaction relationship network.Finally,DAVID database was used to do GO function enrichment analysis and KEGG signaling pathway enrichment analysis for the intersection genes,and the results of GO and KEGG were visualized.Results:1.A total of 7 potential active ingredients and 100 target proteins were screened.2.There are a total of 34 intersection genes between the potential active ingredient target in Linderae Radix in DN.3.The top 10 of the interaction correlation between intersection proteins include:AR and NCOA2,NCOA2 and NR3C1,NCOA2 and PPARG,etc.4.There were 16 entries of molecular function,9 entries of cell component,47 entries of biological process and 18 entries of signaling pathway(P<0.05).Conclusion:DN was treated by Linderae Radix from multi-component,multi-target and multi-link synergies.展开更多
What is already known about this topic?Tropical cyclone(TC)has a substantial and adverse impact on non-accidental mortality.However,whether heterogeneity exists when examining deaths from subcauses and how TC impacts ...What is already known about this topic?Tropical cyclone(TC)has a substantial and adverse impact on non-accidental mortality.However,whether heterogeneity exists when examining deaths from subcauses and how TC impacts non-accidental mortality in the short term remain unclear.What is added by this report?This study found substantial associations at lag 0 between TC exposure and circulatory and respiratory mortality.TC exposures were associated with increased risks for several mortality sub-causes at lag 0 day,including ischemic heart disease,myocardial infarction,cardiac arrest,cerebrovascular disease,stroke,chronic obstructive pulmonary disease,and Parkinson’s disease.What are the implications for public health practice?This finding suggests an urgent need to expand the public health focus of natural disaster management to include non-accidental mortality and sub-causes.展开更多
What is already known about this topic?An increasing number of studies have projected temperature-related mortality,but few consider the change of population’s adaptability to future temperature and mortality burden ...What is already known about this topic?An increasing number of studies have projected temperature-related mortality,but few consider the change of population’s adaptability to future temperature and mortality burden from cold and heat effects.What is added by this report?This study offers a comprehensive characterization of human adaptability and excess mortality burden of temperature across various regions of China.What are the implications for public health practice?The temperature-related excess mortality was projected to increase in the 2050s and decrease in the 2080s.Heat adaptability was projected to increase in the future,but along with the rising temperatures,the heatrelated excess mortality continuously rose,except for the low-speed rising scenario.Although the excess mortality of cold was projected to decrease in the nearer future,it might not keep declining in the long run,due to the decreasing cold-adaptability,which deserves more attention.展开更多
Summary What is already known about this topic?Short-term exposure to air pollutants has been associated with chronic obstructive pulmonary disease(COPD)and asthma,which needs continuous observation.What is added by t...Summary What is already known about this topic?Short-term exposure to air pollutants has been associated with chronic obstructive pulmonary disease(COPD)and asthma,which needs continuous observation.What is added by this report?This study uses the longest time series data so far from 2013 to 2018 and adds additional data analysis for ozone(O_(3))to existing studies.展开更多
基金the Natural Science Foundation of Hainan Province(No.:2019CXTD407)the National Natural Science Foundation of China(No.:81860836).
文摘Objective:To analyze the components and mechanisms of Wuyao(Linderae Radix)in treating diabetic nephropathy(DN)based on network pharmacology.Methods:Multiple online databases were used to search and screen out the active ingredients from Linderae Radix,the related targets of active components of Linderae Radix and the genes related to DN.Search the corresponding genes name of target through UniProt database.Cytoscape 3.2.1 was used to construct the corresponding target gene network of Linderae Radix compounds.Venn diagram was used to screen the intersection genes of the active components corresponding to the target and disease-related genes,and the intersection genes were constructed into the protein interaction relationship network.Finally,DAVID database was used to do GO function enrichment analysis and KEGG signaling pathway enrichment analysis for the intersection genes,and the results of GO and KEGG were visualized.Results:1.A total of 7 potential active ingredients and 100 target proteins were screened.2.There are a total of 34 intersection genes between the potential active ingredient target in Linderae Radix in DN.3.The top 10 of the interaction correlation between intersection proteins include:AR and NCOA2,NCOA2 and NR3C1,NCOA2 and PPARG,etc.4.There were 16 entries of molecular function,9 entries of cell component,47 entries of biological process and 18 entries of signaling pathway(P<0.05).Conclusion:DN was treated by Linderae Radix from multi-component,multi-target and multi-link synergies.
基金This project has received funding from the National Natural Science Foundation of China(92043301).
文摘What is already known about this topic?Tropical cyclone(TC)has a substantial and adverse impact on non-accidental mortality.However,whether heterogeneity exists when examining deaths from subcauses and how TC impacts non-accidental mortality in the short term remain unclear.What is added by this report?This study found substantial associations at lag 0 between TC exposure and circulatory and respiratory mortality.TC exposures were associated with increased risks for several mortality sub-causes at lag 0 day,including ischemic heart disease,myocardial infarction,cardiac arrest,cerebrovascular disease,stroke,chronic obstructive pulmonary disease,and Parkinson’s disease.What are the implications for public health practice?This finding suggests an urgent need to expand the public health focus of natural disaster management to include non-accidental mortality and sub-causes.
基金This work was supported by the National Natural Science Foundation of China （Grant No. 40905069）, China EPA Charity Special Fund （No.201009032）, and State Key Laboratory Special Fund （No. 13Z05ESPCP）.
文摘不稳定的有机化合物(VOC ) 和羰基混合物在 50 个住处在室内并且在户外被测量在加热的北京(2011 年 12 月) 和非加热的季节(4 月 /5 月， 2012 ) 。为 VOC 的 SUMMA 罐和为羰基混合物的散开的刺绣花样在每个地点为 24 h 被部署，并且 94 混合物被确定。甲醛，丙酮和乙醛与是的室内的中部的集中在室内并且在户外是最丰富的羰基混合物 32.1， 21.7 和 15.3 g ??
基金The Special Foundation of Basic Science and Technology Resources Survey of Ministry of Science and Technology of China(Grant No.2017FY101204)National High-level Talents Special Support Plan of China for Young Talents.
文摘What is already known about this topic?An increasing number of studies have projected temperature-related mortality,but few consider the change of population’s adaptability to future temperature and mortality burden from cold and heat effects.What is added by this report?This study offers a comprehensive characterization of human adaptability and excess mortality burden of temperature across various regions of China.What are the implications for public health practice?The temperature-related excess mortality was projected to increase in the 2050s and decrease in the 2080s.Heat adaptability was projected to increase in the future,but along with the rising temperatures,the heatrelated excess mortality continuously rose,except for the low-speed rising scenario.Although the excess mortality of cold was projected to decrease in the nearer future,it might not keep declining in the long run,due to the decreasing cold-adaptability,which deserves more attention.
基金The National Natural Science Foundation of China(81970043 and 91843302)the CAMS Innovation Fund for Medical Sciences(CIFMS)(2020-I2M-2-009)the National Research Program for Key Issues in Air Pollution Control(DQGG0402).
文摘Summary What is already known about this topic?Short-term exposure to air pollutants has been associated with chronic obstructive pulmonary disease(COPD)and asthma,which needs continuous observation.What is added by this report?This study uses the longest time series data so far from 2013 to 2018 and adds additional data analysis for ozone(O_(3))to existing studies.
