Dear Editor,COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is still a threat to millions of lives worldwide.Although SARS-CoV-2 vaccines have been approved to reduce the severit...Dear Editor,COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is still a threat to millions of lives worldwide.Although SARS-CoV-2 vaccines have been approved to reduce the severity and death associated with COVID-19,the number of SARS-CoV-2-infected cases still remains high,especially with the appearance of various mutant strains such as P.1.351 and P.1.617(also known as South Africa strain and India strain,respectively),which may reduce the efficacy of vaccine protection.There is an urgent need to develop effective antiviral agents to treat C0VID-19 patients,especially with those infected with SARS-CoV-2 variants of concern.展开更多
基金This project is supported by the Chinese Academy of Medical Sciences Initiative for Innovative Medicine(2021-I2M-1-047,2019-I2M-5-049 and 2016-I2M-1-005)Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2020-PT310-006,2019XK310002,2018TX31001,and 3332018131)+5 种基金the National Natural Science Foundation of China(91542201,81925025,82102371,82174055,82073181,81802870,and 2017YFA0506200)the National Key Research and Development Project(2020YFC0841700)NIH R01AI069120,AI158154,and AI140718 grants,the UCLA AIDS InstituteUCLA David Geffen School of Medicine-Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research Award Program.H.Y.is supported by science funds from Jiangsu Province(BK20211554,BK20170407)the Innovative and Entrepreneurial Team grant(2018-2021)from Jiangsu Province.L.L.is supported by InnovativeEntrepreneurial Doctor grant(2020-2022)from Jiangsu Province.R.L.is supported by the Chinese Postdoctoral Science Foundation(2020T130135ZX).
文摘Dear Editor,COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is still a threat to millions of lives worldwide.Although SARS-CoV-2 vaccines have been approved to reduce the severity and death associated with COVID-19,the number of SARS-CoV-2-infected cases still remains high,especially with the appearance of various mutant strains such as P.1.351 and P.1.617(also known as South Africa strain and India strain,respectively),which may reduce the efficacy of vaccine protection.There is an urgent need to develop effective antiviral agents to treat C0VID-19 patients,especially with those infected with SARS-CoV-2 variants of concern.
