The epithelial-mesenchymal transition(EMT)is a highly complex phenotypic conversion during embryogenesis,and is important for metastasis,which contributes to tumor deterioration and poor prognoses of cancer patients.L...The epithelial-mesenchymal transition(EMT)is a highly complex phenotypic conversion during embryogenesis,and is important for metastasis,which contributes to tumor deterioration and poor prognoses of cancer patients.Lung carcinoma has a high tendency to develop the EMT.Circular RNAs(circ RNAs)are involved in EMT-related cell invasion and metastasis in various types of cancers.Moreover,circ RNAs have been found to be a link to EMT-related transcription factors and EMT-associated signaling pathways.This review mainly focuses on the influence of EMT-related circ RNAs on lung carcinomas.More specifically,the roles of EMT-inducingand EMT-suppressive circ RNAs in lung carcinomas are discussed.With circ RNAs potentially becoming promising biomarkers and therapeutic targets for cancer managements,they will hopefully stimulate the interest of medical workers in the early diagnosis,personalized treatment,and positive prognoses in the era of precision oncology.展开更多
with expansion of rural empty nesters,endowment of empty nesters has become a hot spot of the society. By means of questionnaire survey and interview,this paper analyzed basic situations of empty nesters in Tulu Villa...with expansion of rural empty nesters,endowment of empty nesters has become a hot spot of the society. By means of questionnaire survey and interview,this paper analyzed basic situations of empty nesters in Tulu Village of Hunchun City in Jilin Province,including economic level,physical health,life care,and spirit situations. Next,it discussed major problems in endowment problem of empty nesters,including limited economic support,unoptimistic physical health,low ability of life care,and feeling of loneliness. Finally,it came up with pertinent recommendations on the basis of the analysis,including strengthening family endowment ability and improving socialized endowment service,strengthening practical living ability,improving life care ability with family endowment as primary and community endowment as auxiliary part,and expanding amusement and recreation ways of empty nesters.展开更多
Long non-coding RNAs(lncRNAs)reportedly function as important modulators of gene regulation and malignant processes in the development of human cancers.The lncRNA JPX is a novel molecular switch for X chromosome inact...Long non-coding RNAs(lncRNAs)reportedly function as important modulators of gene regulation and malignant processes in the development of human cancers.The lncRNA JPX is a novel molecular switch for X chromosome inactivation and differentially expressed JPX has exhibited certain clinical correlations in several cancers.Notably,JPX participates in cancer growth,metastasis,and chemoresistance,by acting as a competing endogenous RNA for microRNA,interacting with proteins,and regulating some specific signaling pathways.Moreover,JPX may serve as a potential biomarker and therapeutic target for the diagnosis,prognosis,and treatment of cancer.The present article summarizes our current understanding of the structure,expression,and function of JPX in malignant cancer processes and discusses its molecular mechanisms and potential applications in cancer biology and medicine.展开更多
基金supported in part by research grants from the Non-profit Technology Research Program of Zhejiang(Grant No.LGF18H160006)the Non-profit Technology Research Program of Ningbo(Grant No.2019C50040)+2 种基金the Natural Science Foundation of Ningbo(Grant No.2018A610204)the Scientific Innovation Team Project of Ningbo(Grant No.2017C110019)the K.C.Wong Magna Fund at Ningbo University。
文摘The epithelial-mesenchymal transition(EMT)is a highly complex phenotypic conversion during embryogenesis,and is important for metastasis,which contributes to tumor deterioration and poor prognoses of cancer patients.Lung carcinoma has a high tendency to develop the EMT.Circular RNAs(circ RNAs)are involved in EMT-related cell invasion and metastasis in various types of cancers.Moreover,circ RNAs have been found to be a link to EMT-related transcription factors and EMT-associated signaling pathways.This review mainly focuses on the influence of EMT-related circ RNAs on lung carcinomas.More specifically,the roles of EMT-inducingand EMT-suppressive circ RNAs in lung carcinomas are discussed.With circ RNAs potentially becoming promising biomarkers and therapeutic targets for cancer managements,they will hopefully stimulate the interest of medical workers in the early diagnosis,personalized treatment,and positive prognoses in the era of precision oncology.
文摘with expansion of rural empty nesters,endowment of empty nesters has become a hot spot of the society. By means of questionnaire survey and interview,this paper analyzed basic situations of empty nesters in Tulu Village of Hunchun City in Jilin Province,including economic level,physical health,life care,and spirit situations. Next,it discussed major problems in endowment problem of empty nesters,including limited economic support,unoptimistic physical health,low ability of life care,and feeling of loneliness. Finally,it came up with pertinent recommendations on the basis of the analysis,including strengthening family endowment ability and improving socialized endowment service,strengthening practical living ability,improving life care ability with family endowment as primary and community endowment as auxiliary part,and expanding amusement and recreation ways of empty nesters.
基金research grants from the Major Project for Science and Technology Innovation 2025 of Ningbo(No.2019B10037)the K.C.Wong Magna Fund in Ningbo University.
文摘Long non-coding RNAs(lncRNAs)reportedly function as important modulators of gene regulation and malignant processes in the development of human cancers.The lncRNA JPX is a novel molecular switch for X chromosome inactivation and differentially expressed JPX has exhibited certain clinical correlations in several cancers.Notably,JPX participates in cancer growth,metastasis,and chemoresistance,by acting as a competing endogenous RNA for microRNA,interacting with proteins,and regulating some specific signaling pathways.Moreover,JPX may serve as a potential biomarker and therapeutic target for the diagnosis,prognosis,and treatment of cancer.The present article summarizes our current understanding of the structure,expression,and function of JPX in malignant cancer processes and discusses its molecular mechanisms and potential applications in cancer biology and medicine.
