Sericin from discarded silkworm cocoons of silk reeling has been used in different fields, such as cosmetology, skin care, nutrition, and oncology. The present study established a rat model of type 2 diabetes by conse...Sericin from discarded silkworm cocoons of silk reeling has been used in different fields, such as cosmetology, skin care, nutrition, and oncology. The present study established a rat model of type 2 diabetes by consecutive intraperitoneal injections of low-dose （25 mg/kg） streptozotocin. After intragastrical perfusion of sericin for 35 days, blood glucose levels significantly declined, and the expression of neurofilament protein in the sciatic nerve and nerve growth factor in L4-6 spinal ganglion and anterior horn cells significantly increased. However, the expression of neuropeptide Y in spinal ganglion and anterior horn cells significantly decreased in model rats. These findings indicate that sericin protected the sciatic nerve and related nerve cells against injury in a rat type 2 diabetic model by upregulating the expression of neurofilament protein in the sciatic nerve and nerve growth factor in spinal ganglion and anterior horn cells, and downregulating the expression of neuropeptide Y in spinal ganglion and anterior horn cells.展开更多
Traditional medicine has not only made important contributions to the reproduction and prosperity of the Chinese nation for a long time,and it has also had a positive impact on human health and world civilization.Phar...Traditional medicine has not only made important contributions to the reproduction and prosperity of the Chinese nation for a long time,and it has also had a positive impact on human health and world civilization.Pharmaceutical policies have a significant impact on the development of the pharmaceutical industry.In this article,the research on the development of pharmaceutical policies after the founding of the People's Republic of China is summarized.This is of great significance to formulate scientific and efficient policy measures to promote the development of the pharmaceutical industry.展开更多
文摘Sericin from discarded silkworm cocoons of silk reeling has been used in different fields, such as cosmetology, skin care, nutrition, and oncology. The present study established a rat model of type 2 diabetes by consecutive intraperitoneal injections of low-dose （25 mg/kg） streptozotocin. After intragastrical perfusion of sericin for 35 days, blood glucose levels significantly declined, and the expression of neurofilament protein in the sciatic nerve and nerve growth factor in L4-6 spinal ganglion and anterior horn cells significantly increased. However, the expression of neuropeptide Y in spinal ganglion and anterior horn cells significantly decreased in model rats. These findings indicate that sericin protected the sciatic nerve and related nerve cells against injury in a rat type 2 diabetic model by upregulating the expression of neurofilament protein in the sciatic nerve and nerve growth factor in spinal ganglion and anterior horn cells, and downregulating the expression of neuropeptide Y in spinal ganglion and anterior horn cells.
基金Key Research Base of Humanities and Social Sciences in Guangxi Universities and Colleges:Development and Research Center for China-ASEAN Traditional Medicine(0501906419).
文摘Traditional medicine has not only made important contributions to the reproduction and prosperity of the Chinese nation for a long time,and it has also had a positive impact on human health and world civilization.Pharmaceutical policies have a significant impact on the development of the pharmaceutical industry.In this article,the research on the development of pharmaceutical policies after the founding of the People's Republic of China is summarized.This is of great significance to formulate scientific and efficient policy measures to promote the development of the pharmaceutical industry.
