The prevention and treatment of pathological scars remain challenging.Corticosteroids are the mainstay drugs in clinical scar prevention and treatment as they effectively induce scar regression and improve scar prurit...The prevention and treatment of pathological scars remain challenging.Corticosteroids are the mainstay drugs in clinical scar prevention and treatment as they effectively induce scar regression and improve scar pruritus and pain.Currently,intralesional injections of corticosteroids are widely used in clinical practice.These require professional medical manipulation;however,the significant accompanying injection pain,repetition of injections and adverse effects,such as skin atrophy,skin pigmentation and telangiectasia,make this treatment modality an unpleasant experience for patients.Transdermal administration is,therefore,a promising non-invasive and easy-to-use method for corticosteroid administration for scar treatment.In this review,we first summarize the mechanisms of action of corticosteroids in scar prevention and treatment;then,we discuss current developments in intralesional injections and the progress of transdermal delivery systems of corticosteroids,as well as their corresponding advantages and disadvantages.展开更多
基金supported by the National Natural Science Foundation of China(grant numbers:82172222,82272266 and 82102328)the Shanghai Clinical Research Project of Health Industry(20204Y0443)+1 种基金the Cross Research Project of Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine(JYJC202009)the Shanghai Clinical Research Center of Plastic and Reconstructive Surgery supported by Science and Technology Commission of Shanghai Municipality(Grant No.22MC1940300).
文摘The prevention and treatment of pathological scars remain challenging.Corticosteroids are the mainstay drugs in clinical scar prevention and treatment as they effectively induce scar regression and improve scar pruritus and pain.Currently,intralesional injections of corticosteroids are widely used in clinical practice.These require professional medical manipulation;however,the significant accompanying injection pain,repetition of injections and adverse effects,such as skin atrophy,skin pigmentation and telangiectasia,make this treatment modality an unpleasant experience for patients.Transdermal administration is,therefore,a promising non-invasive and easy-to-use method for corticosteroid administration for scar treatment.In this review,we first summarize the mechanisms of action of corticosteroids in scar prevention and treatment;then,we discuss current developments in intralesional injections and the progress of transdermal delivery systems of corticosteroids,as well as their corresponding advantages and disadvantages.
