The correlation between Epstein-Barr virus(EBV)infection and nasopharyngeal carcinoma(NPC)risk has been extensively researched.The continual monitoring of EBV-IgAs provides a promising approach of NPC screening in its...The correlation between Epstein-Barr virus(EBV)infection and nasopharyngeal carcinoma(NPC)risk has been extensively researched.The continual monitoring of EBV-IgAs provides a promising approach of NPC screening in its early stage.In this study,we successfully synthesized a single-atom nanozyme(SANzyme)through the application of iron-porphyrin based metal organic framework(MOF-FeP).The MOF-FeP possesses precisely-defined electronic and geometric structures that accurately mimic highly-evolved catalytic site of natural peroxidase.The peroxidase-like activity of MOF-FeP enables it to catalyze the chemiluminescence of luminol substrate.By integrating MOF-FeP into a traditional strip,we created a rapid and highly-sensitive evaluation tool for detecting EBV-IgAs.Importantly,the MOF-FeP strip enables the simultaneous detection of three EBV-IgAs,greatly improving the accuracy of EBV-associated NPC screening.The sensitivities of the MOF-FeP strip(75.56%–93.30%)surpass those of current enzyme-linked immunosorbent assay(ELISA)methods(64.44%–82.22%).This test takes only 16 min to perform as opposed to the customary 1–2 h required for standard ELISA.Additionally,the MOF-FeP strip is suitable for whole blood samples,thereby significantly simplifying the sample preparation and detection process.In conclusion,the MOF-FeP strip combines the simplicity of traditional strip with the high catalytic activity of SANzyme.Our innovative MOF-FeP strip offers a new point-of-care strategy for EBV-IgAs detection,which is expected to markedly facilitate early screening for EBV-associated diseases.展开更多
To the Editor:The risk factors for the development of radiographic axial spondyloarthritis(SpA)are still uncertain.Previous studies found that a high concentration of serum uric acid(SUA)leads to deposition of monosod...To the Editor:The risk factors for the development of radiographic axial spondyloarthritis(SpA)are still uncertain.Previous studies found that a high concentration of serum uric acid(SUA)leads to deposition of monosodium urate(MSU)in different joints of other rheumatic arthritis diseases except gout.Furthermore,it has been reported that gout could mimic SpA.Thus,our study explored whether the development of radiographic axial SpA is related to high SUA concentration.展开更多
基金supported by the National Key Research and Development Program of China(No.2019YFA0709204)the National Natural Science Foundation of China(No.32200744)+2 种基金the Natural Science Foundation of Guangdong Province(Nos.2021A1515110028 and 2022A1515220147)the Science and Technology Program for Basic Research in Shenzhen(Nos.JCYJ20210324103015039,JCYJ20190809095811254,and JCYJ20200109140412476)the National Natural Science Foundation of China(Nos.81930050 and 22121003).
文摘The correlation between Epstein-Barr virus(EBV)infection and nasopharyngeal carcinoma(NPC)risk has been extensively researched.The continual monitoring of EBV-IgAs provides a promising approach of NPC screening in its early stage.In this study,we successfully synthesized a single-atom nanozyme(SANzyme)through the application of iron-porphyrin based metal organic framework(MOF-FeP).The MOF-FeP possesses precisely-defined electronic and geometric structures that accurately mimic highly-evolved catalytic site of natural peroxidase.The peroxidase-like activity of MOF-FeP enables it to catalyze the chemiluminescence of luminol substrate.By integrating MOF-FeP into a traditional strip,we created a rapid and highly-sensitive evaluation tool for detecting EBV-IgAs.Importantly,the MOF-FeP strip enables the simultaneous detection of three EBV-IgAs,greatly improving the accuracy of EBV-associated NPC screening.The sensitivities of the MOF-FeP strip(75.56%–93.30%)surpass those of current enzyme-linked immunosorbent assay(ELISA)methods(64.44%–82.22%).This test takes only 16 min to perform as opposed to the customary 1–2 h required for standard ELISA.Additionally,the MOF-FeP strip is suitable for whole blood samples,thereby significantly simplifying the sample preparation and detection process.In conclusion,the MOF-FeP strip combines the simplicity of traditional strip with the high catalytic activity of SANzyme.Our innovative MOF-FeP strip offers a new point-of-care strategy for EBV-IgAs detection,which is expected to markedly facilitate early screening for EBV-associated diseases.
基金Science and Technology Program for Basic Research in Shenzhen(Nos.JCYJ20190809095811254,JCYJ20200109140412476)
文摘To the Editor:The risk factors for the development of radiographic axial spondyloarthritis(SpA)are still uncertain.Previous studies found that a high concentration of serum uric acid(SUA)leads to deposition of monosodium urate(MSU)in different joints of other rheumatic arthritis diseases except gout.Furthermore,it has been reported that gout could mimic SpA.Thus,our study explored whether the development of radiographic axial SpA is related to high SUA concentration.
