Liver injury in the setting of human immunodeficiency virus(HIV) infection is more commonly attributed to viral hepatitis or highly active antiretroviral treatment(HAART) toxicity. The severity of liver injury is an i...Liver injury in the setting of human immunodeficiency virus(HIV) infection is more commonly attributed to viral hepatitis or highly active antiretroviral treatment(HAART) toxicity. The severity of liver injury is an important cause of morbidity and mortality. The emergence of autoimmune diseases, particularly autoimmune hepatitis(AIH) in the setting of HIV infection, is rare. Previous reports indicate that elevated liver enzymes are a common denominator amongst these patients. We present two patients with HIV infection, on HAART, with virological suppression. Both patients presented with elevated liver enzymes, and following liver biopsies, were diagnosed with AIH. The clinical course of these patients underscore the therapeutic value of corticosteroids, and in some cases, addition of immunosuppression for AIH treatment.展开更多
文摘Liver injury in the setting of human immunodeficiency virus(HIV) infection is more commonly attributed to viral hepatitis or highly active antiretroviral treatment(HAART) toxicity. The severity of liver injury is an important cause of morbidity and mortality. The emergence of autoimmune diseases, particularly autoimmune hepatitis(AIH) in the setting of HIV infection, is rare. Previous reports indicate that elevated liver enzymes are a common denominator amongst these patients. We present two patients with HIV infection, on HAART, with virological suppression. Both patients presented with elevated liver enzymes, and following liver biopsies, were diagnosed with AIH. The clinical course of these patients underscore the therapeutic value of corticosteroids, and in some cases, addition of immunosuppression for AIH treatment.
