Figure 1.EGFR activation promotes TLR4 phosphorylation and cell surface expression of TLR4 in response to LPS.(A and B)BMDM were treated with LPS(1μg/mL)for 6,12,or 24 h in the presence or absence of pretreatment of ...Figure 1.EGFR activation promotes TLR4 phosphorylation and cell surface expression of TLR4 in response to LPS.(A and B)BMDM were treated with LPS(1μg/mL)for 6,12,or 24 h in the presence or absence of pretreatment of PD or TAPI-1.(A)Flow cytometry analysis of cell surface TLR4 intensity in BMDM.(B)Flow cytometry analysis of cell surface TLR4 intensity in BMDM.(C and D)WT(C57BL76)mice were treated with LPS(10 mg/kg,i.p.).In some groups,mice were pretreated with erlotinib(100 mg/kg,gavage administration)at 30 min prior to LPS i.p.展开更多
Viral infection in the liver,including hepatitis B virus (HBV) and hepatitis C virus (HCV) infection,is a major health problem worldwide,especially in developing countries.The infection triggers a pro-inflammatory res...Viral infection in the liver,including hepatitis B virus (HBV) and hepatitis C virus (HCV) infection,is a major health problem worldwide,especially in developing countries.The infection triggers a pro-inflammatory response in patients that is crucial for host defense.Recent studies have identified multiple transmembrane and cytosolic receptors that recognize pathogen-derived nucleic acids,and these receptors are essential for driving immune activation in the liver.In addition to sensing DNA/RNA from pathogens,these intracellular receptors can be activated by nucleic acids of host origin in response to sterile injuries.In this review,we discuss the expanding roles of these receptors in both immune and nonimmune cells in the liver.展开更多
文摘Figure 1.EGFR activation promotes TLR4 phosphorylation and cell surface expression of TLR4 in response to LPS.(A and B)BMDM were treated with LPS(1μg/mL)for 6,12,or 24 h in the presence or absence of pretreatment of PD or TAPI-1.(A)Flow cytometry analysis of cell surface TLR4 intensity in BMDM.(B)Flow cytometry analysis of cell surface TLR4 intensity in BMDM.(C and D)WT(C57BL76)mice were treated with LPS(10 mg/kg,i.p.).In some groups,mice were pretreated with erlotinib(100 mg/kg,gavage administration)at 30 min prior to LPS i.p.
基金Work funded through grant from NIH to TRB (R01GM044100)
文摘Viral infection in the liver,including hepatitis B virus (HBV) and hepatitis C virus (HCV) infection,is a major health problem worldwide,especially in developing countries.The infection triggers a pro-inflammatory response in patients that is crucial for host defense.Recent studies have identified multiple transmembrane and cytosolic receptors that recognize pathogen-derived nucleic acids,and these receptors are essential for driving immune activation in the liver.In addition to sensing DNA/RNA from pathogens,these intracellular receptors can be activated by nucleic acids of host origin in response to sterile injuries.In this review,we discuss the expanding roles of these receptors in both immune and nonimmune cells in the liver.
