Aim: To investigate the possible relationship between serumlevels and avidities of antibodies against tetanus toxoid (TT)-and Haemophilus influenzae type b (Hib) in children that were vaccinated after treatment for ch...Aim: To investigate the possible relationship between serumlevels and avidities of antibodies against tetanus toxoid (TT)-and Haemophilus influenzae type b (Hib) in children that were vaccinated after treatment for childhood acute lymphoblastic leukaemia (ALL). Methods: The study groups were 31 paediatric patients with ALL and 18 healthy controls. All subjects were vaccinated with TT and a protein conjugated Hib vaccine.Antibody levels were analysed at three time points: At diagnosis of ALL, after cessation of treatment before vaccination and three weeks after vaccination. Avidity was measured twice,with a thiocyanate elution assay, at diagnosis of ALL and three weeks after vaccination. Results: There was a correlation between level and avidity of tetanus antibodies after vaccination(r s =0.59)Conclusion: The vaccination strategy after childhood ALL must be different for low-risk and high-risk ALL groups, since the high-risk group fail to elicit a recall response to tetanus.展开更多
A testicular tumor in a 12- year-old boy proved to be a carcinoid tumor. An extensive investigation including a computed tomographic scan of the abdominal and pelvic region as well as both 123I-labeled metaiodobenzylg...A testicular tumor in a 12- year-old boy proved to be a carcinoid tumor. An extensive investigation including a computed tomographic scan of the abdominal and pelvic region as well as both 123I-labeled metaiodobenzylguanidine and 111In-coupled octreotide scintigraphy was normal. Because histopathologic examination of the primary surgical specimen revealed tumor growth in the resection border of the spermatic vessels, a second operation with unilateral lymph node dissectionwas performed. Surprisingly, 3 lymph node metastases were found. No further treatment was given and the boy is alive without disease 9 years after surgery. This case illustrates that modern scintigraphic techniques do not always detect carcinoid tumors. Because carcinoids respond poorly to other treatment modalities, the importance of initial radical surgery including a meticulous examination of regional lymph nodes is emphasized.展开更多
This study examined whether the initial plasma levels of tumour necrosis factor α (TNFα ) and interferon γ (IFNγ ) in 131 children with newly diagnosed cancer were associated with haematopoietic suppression, and w...This study examined whether the initial plasma levels of tumour necrosis factor α (TNFα ) and interferon γ (IFNγ ) in 131 children with newly diagnosed cancer were associated with haematopoietic suppression, and whether plasma levels of TNFα or haemoglobin at diagnosis affects long-term prognosis in childhood acute lymphoblastic leukaemia (ALL). Conclusions: IFNγ , and possibly also TNFα , were related to anaemia in children with solid tumours. Neither TNFα levels nor Hb levels were associated with increased risk of ALL relapse.展开更多
文摘Aim: To investigate the possible relationship between serumlevels and avidities of antibodies against tetanus toxoid (TT)-and Haemophilus influenzae type b (Hib) in children that were vaccinated after treatment for childhood acute lymphoblastic leukaemia (ALL). Methods: The study groups were 31 paediatric patients with ALL and 18 healthy controls. All subjects were vaccinated with TT and a protein conjugated Hib vaccine.Antibody levels were analysed at three time points: At diagnosis of ALL, after cessation of treatment before vaccination and three weeks after vaccination. Avidity was measured twice,with a thiocyanate elution assay, at diagnosis of ALL and three weeks after vaccination. Results: There was a correlation between level and avidity of tetanus antibodies after vaccination(r s =0.59)Conclusion: The vaccination strategy after childhood ALL must be different for low-risk and high-risk ALL groups, since the high-risk group fail to elicit a recall response to tetanus.
文摘A testicular tumor in a 12- year-old boy proved to be a carcinoid tumor. An extensive investigation including a computed tomographic scan of the abdominal and pelvic region as well as both 123I-labeled metaiodobenzylguanidine and 111In-coupled octreotide scintigraphy was normal. Because histopathologic examination of the primary surgical specimen revealed tumor growth in the resection border of the spermatic vessels, a second operation with unilateral lymph node dissectionwas performed. Surprisingly, 3 lymph node metastases were found. No further treatment was given and the boy is alive without disease 9 years after surgery. This case illustrates that modern scintigraphic techniques do not always detect carcinoid tumors. Because carcinoids respond poorly to other treatment modalities, the importance of initial radical surgery including a meticulous examination of regional lymph nodes is emphasized.
文摘This study examined whether the initial plasma levels of tumour necrosis factor α (TNFα ) and interferon γ (IFNγ ) in 131 children with newly diagnosed cancer were associated with haematopoietic suppression, and whether plasma levels of TNFα or haemoglobin at diagnosis affects long-term prognosis in childhood acute lymphoblastic leukaemia (ALL). Conclusions: IFNγ , and possibly also TNFα , were related to anaemia in children with solid tumours. Neither TNFα levels nor Hb levels were associated with increased risk of ALL relapse.
