The supergiant Shuangjianzishan(SJZ) Ag-Pb-Zn deposit is in the southern segment of the Great Hinggan Range(SGHR), northeast China. Previous studies suggest the ore-forming material and fluid originated from the magma...The supergiant Shuangjianzishan(SJZ) Ag-Pb-Zn deposit is in the southern segment of the Great Hinggan Range(SGHR), northeast China. Previous studies suggest the ore-forming material and fluid originated from the magmatic system, and the mineralization age was consistent with the diagenetic age. However,the relationship between granitic magmatism and mineralization is still unclear in the SJZ. In this study, CH-O-He-Ar and in-situ S-Pb isotope analyses were conducted to determine the sources of ore-forming fluids and metals, which were combined with geochemistry data of SJZ granitoids from previous studies to constrain the relationship between the magmatism and the mineralization. The C-H-O-He-Ar-S-Pb isotopic compositions suggested the SJZ ore-forming material and fluids were derived from a magmatic source, which has mixed a small amount of mantle-derived materials. In addition, the disseminated sulfide from the syenogranite has comparable S-Pb isotopic composition with the sulfide minerals from ore veins,suggesting that the generation of the SJZ ore-forming fluids has a close relationship with the syenogranite magmatism. Combining with the geochemical characters of the syenogranite, the authors proposed that the mantle-derived fingerprint of the SJZ ore-forming fluid might be caused by the parent magma of the syenogranite, which was derived from partial melting of the juvenile lower crust, and underwent the residual melts segregated from a crystal mush in the shallow magma reservoir. The extraction of the syenogranite parent magma further concentrated the fertilized fluids, which was crucial to mineralization of the SJZ Ag-Pb-Zn deposit.展开更多
Gastroenteropancreatic neuroendocrine neoplasms(GEP-NENs)are a rare group of tumors originating from neuroendocrine cells of the digestive system.Their incidence has increased over the last decades.The specific pathog...Gastroenteropancreatic neuroendocrine neoplasms(GEP-NENs)are a rare group of tumors originating from neuroendocrine cells of the digestive system.Their incidence has increased over the last decades.The specific pathogenetic mechanisms underlying GEP-NEN development have not been completely revealed.Unfunctional GEP-NENs are usually asymptomatic;some grow slowly and thus impede early diagnosis,which ultimately results in a high rate of misdiagnosis.Therefore,many GEP-NEN patients present with later staged tumors.Motivated hereby,research attention for diagnosis and treatment for GEP-NENs increased in recent years.The result of which is great progress in clinical diagnosis and treatment.According to the most recent clinical guidelines,improved grading standards can accurately define poorly differentiated grade 3 neuroendocrine tumors and neuroendocrine carcinomas(NECs),which are subclassified into large and small cell NECs.Combining different functional imaging methods facilitates precise diagnosis.The expression of somatostatin receptors helps to predict prognosis.Genetic analyses of mutations affecting death domain associated protein(DAXX),multiple endocrine neoplasia type 1(MEN 1),alpha thalassemia/intellectual disability syndrome X-linked(ATRX),retinoblastoma transcriptional corepressor 1(RB 1),and mothers against decapentaplegic homolog 4(SMAD 4)help distinguishing grade 3 NENs from poorly differentiated NECs.The aim of this review is to summarize the latest research progress on diagnosis and treatment of GEP-NENs.展开更多
The S-scheme heterojunction has garnered increasing attention due to its remarkable oxidation capacity and efficient separation of photogenerated carriers.In this study,a one-pot glycerol-assisted hydrothermal process...The S-scheme heterojunction has garnered increasing attention due to its remarkable oxidation capacity and efficient separation of photogenerated carriers.In this study,a one-pot glycerol-assisted hydrothermal process was utilized to successfully synthesize S-scheme heterojunction photocatalysts comprising basic bismuth nitrate(BBN)and bismuth tungstate(BWO).Interestingly,the BBN/BWO heterogeneous photo-catalysts exhibited the highest photocatalytic properties.The optimized product achieved the degradation of sulfamethazine(SMZ)within 1 h,with a kinetic constant(k)value of 0.05818 min^(−1).The degradation process was influenced significantly by·O^(2)−and h^(+)species.To determine the degradation pathway of SMZ in the presence of BBN/BWO-0.6,liquid chromatography-mass spectrometry(LC-MS)analysis was performed,which revealed a decrease in the toxicity of intermediates and products.The enhanced pho-tocatalytic activity can be attributed to the internal electric field(IEF)of the S-scheme heterojunction between BBN and BWO,effectively promoting the separation of photogenerated carriers.This research presents a viable approach for developing S-scheme heterojunctions in SMZ photodegradation and other environmental applications.展开更多
Malnutrition in early life increases the risk of osteoporosis,but the association of early-life undernutrition combined with adulthood obesity patterns with low-energy fracture remains unknown.This study included 5323...Malnutrition in early life increases the risk of osteoporosis,but the association of early-life undernutrition combined with adulthood obesity patterns with low-energy fracture remains unknown.This study included 5323 community-dwelling subjects aged⩾40 years from China.Early-life famine exposure was identified based on the participants’birth dates.General obesity was assessed using the body mass index(BMI),and abdominal obesity was evaluated with the waist-to-hip ratio(WHR).Low-energy fracture was defined as fracture occurring after the age of⩾40 typically caused by falls from standing height or lower.Compared to the nonexposed group,the group with fetal,childhood,and adolescence famine exposure was associated with an increased risk of fracture in women with odds ratios(ORs)and 95%confidence intervals(CIs)of 3.55(1.57–8.05),3.90(1.57–9.71),and 3.53(1.05–11.88),respectively,but not in men.Significant interactions were observed between fetal famine exposure and general obesity with fracture among women(P for interaction=0.0008).Furthermore,compared with the groups with normal BMI and WHR,the group of women who underwent fetal famine exposure and had both general and abdominal obesity had the highest risk of fracture(OR,95%CI:3.32,1.17–9.40).These results indicate that early-life famine exposure interacts with adulthood general obesity and significantly increases the risk of low-energy fracture later in life in women.展开更多
The recombination of photogenerated electrons and holes is a crucial factor limiting photocatalytic H_(2)evolution.The S-scheme ZnWO_(4)-ZnIn_(2)S_(4)heterojunction with 2D coupling interfaces was successfully synthes...The recombination of photogenerated electrons and holes is a crucial factor limiting photocatalytic H_(2)evolution.The S-scheme ZnWO_(4)-ZnIn_(2)S_(4)heterojunction with 2D coupling interfaces was successfully synthesized using a simple solvothermal method.An effective S-scheme interfacial charge migration route at the S-scheme heterogeneous interface was determined by energy band structure analyses(such as UPS,Mott-Schottky and XPS plots),which facilitates the separation of photoexcited carriers.It is worth noting that the optimal ZnWO_(4)-ZnIn_(2)S_(4)composite has an H_(2)evolution activity of 4925.3μmol g^(-1)h^(-1)with favourable photostability and stability.Meanwhile,the ZnWO_(4)-Zn In_(2)S_(4)heterojunction exhibits the maximum optical response value(2.8 m A cm-2)in the initial stage,effectively promoting the separation and migration of photogenerated carriers.The establishment of the built-in electric field direction at the interface can effectively promote the space charge separation between the ZnWO_(4)and ZnIn_(2)S_(4)nanosheets,which is favorable to the photocatalytic H_(2)evolution.This work provides valuable guidance for designing S-scheme heterojunction photocatalysts composed of two n-type semiconductors for energy and environmental applications.The recombination of photogenerated electrons and holes is a crucial factor limiting photocatalytic H_(2)evolution.The S-scheme ZnWO_(4)-ZnIn_(2)S_(4)heterojunction with 2D coupling interfaces was successfully synthesized using a simple solvothermal method.An effective S-scheme interfacial charge migration route at the S-scheme heterogeneous interface was determined by energy band structure analyses(such as UPS,Mott-Schottky and XPS plots),which facilitates the separation of photoexcited carriers.It is worth noting that the optimal ZnWO_(4)-ZnIn_(2)S_(4)composite has an H_(2)evolution activity of 4925.3μmol g^(-1)h^(-1)with favourable photostability and stability.Meanwhile,the ZnWO_(4)-ZnIn_(2)S_(4)heterojunction exhibits the maximum optical response value(2.8 m A cm-2)in the initial stage,effectively promoting the separation and migration of photogenerated carriers.The establishment of the built-in electric field direction at the interface can effectively promote the space charge separation between the ZnWO_(4)and Zn In_(2)S_(4)nanosheets,which is favorable to the photocatalytic H_(2)evolution.This work provides valuable guidance for designing S-scheme heterojunction photocatalysts composed of two n-type semiconductors for energy and environmental applications.展开更多
基金supported financially by the China Geological Survey project [DD20160123 (DD-16-049, D1522), DD20160050, DD20190370]the Fundamental Research Funds for the Central Universities (310827171122)the National Natural Science Foundation of China (Grant 41672068)。
文摘The supergiant Shuangjianzishan(SJZ) Ag-Pb-Zn deposit is in the southern segment of the Great Hinggan Range(SGHR), northeast China. Previous studies suggest the ore-forming material and fluid originated from the magmatic system, and the mineralization age was consistent with the diagenetic age. However,the relationship between granitic magmatism and mineralization is still unclear in the SJZ. In this study, CH-O-He-Ar and in-situ S-Pb isotope analyses were conducted to determine the sources of ore-forming fluids and metals, which were combined with geochemistry data of SJZ granitoids from previous studies to constrain the relationship between the magmatism and the mineralization. The C-H-O-He-Ar-S-Pb isotopic compositions suggested the SJZ ore-forming material and fluids were derived from a magmatic source, which has mixed a small amount of mantle-derived materials. In addition, the disseminated sulfide from the syenogranite has comparable S-Pb isotopic composition with the sulfide minerals from ore veins,suggesting that the generation of the SJZ ore-forming fluids has a close relationship with the syenogranite magmatism. Combining with the geochemical characters of the syenogranite, the authors proposed that the mantle-derived fingerprint of the SJZ ore-forming fluid might be caused by the parent magma of the syenogranite, which was derived from partial melting of the juvenile lower crust, and underwent the residual melts segregated from a crystal mush in the shallow magma reservoir. The extraction of the syenogranite parent magma further concentrated the fertilized fluids, which was crucial to mineralization of the SJZ Ag-Pb-Zn deposit.
基金Supported by China Scholarship Council,No. 202108080085 to (Dai M) and No. 201908080127 to (Lu LL)
文摘Gastroenteropancreatic neuroendocrine neoplasms(GEP-NENs)are a rare group of tumors originating from neuroendocrine cells of the digestive system.Their incidence has increased over the last decades.The specific pathogenetic mechanisms underlying GEP-NEN development have not been completely revealed.Unfunctional GEP-NENs are usually asymptomatic;some grow slowly and thus impede early diagnosis,which ultimately results in a high rate of misdiagnosis.Therefore,many GEP-NEN patients present with later staged tumors.Motivated hereby,research attention for diagnosis and treatment for GEP-NENs increased in recent years.The result of which is great progress in clinical diagnosis and treatment.According to the most recent clinical guidelines,improved grading standards can accurately define poorly differentiated grade 3 neuroendocrine tumors and neuroendocrine carcinomas(NECs),which are subclassified into large and small cell NECs.Combining different functional imaging methods facilitates precise diagnosis.The expression of somatostatin receptors helps to predict prognosis.Genetic analyses of mutations affecting death domain associated protein(DAXX),multiple endocrine neoplasia type 1(MEN 1),alpha thalassemia/intellectual disability syndrome X-linked(ATRX),retinoblastoma transcriptional corepressor 1(RB 1),and mothers against decapentaplegic homolog 4(SMAD 4)help distinguishing grade 3 NENs from poorly differentiated NECs.The aim of this review is to summarize the latest research progress on diagnosis and treatment of GEP-NENs.
基金supported by the National Natural Science Foundation of China(No.22278245)the Young Taishan Scholars Program of Shandong Province(No.tsqn.201909026)+1 种基金the Youth Interdisciplinary Science and Innovative Research Groups of Shandong University supported by the Fundamental Research Funds for the Central Universities(No.2020QNQT014)the Shandong University Future Youth Grant Program(No.61440089964189).
文摘The S-scheme heterojunction has garnered increasing attention due to its remarkable oxidation capacity and efficient separation of photogenerated carriers.In this study,a one-pot glycerol-assisted hydrothermal process was utilized to successfully synthesize S-scheme heterojunction photocatalysts comprising basic bismuth nitrate(BBN)and bismuth tungstate(BWO).Interestingly,the BBN/BWO heterogeneous photo-catalysts exhibited the highest photocatalytic properties.The optimized product achieved the degradation of sulfamethazine(SMZ)within 1 h,with a kinetic constant(k)value of 0.05818 min^(−1).The degradation process was influenced significantly by·O^(2)−and h^(+)species.To determine the degradation pathway of SMZ in the presence of BBN/BWO-0.6,liquid chromatography-mass spectrometry(LC-MS)analysis was performed,which revealed a decrease in the toxicity of intermediates and products.The enhanced pho-tocatalytic activity can be attributed to the internal electric field(IEF)of the S-scheme heterojunction between BBN and BWO,effectively promoting the separation of photogenerated carriers.This research presents a viable approach for developing S-scheme heterojunctions in SMZ photodegradation and other environmental applications.
基金supported by the Ministry of Science and Technology of China(No.2022YFC2505202)the National Natural Science Foundation of China(Nos.81970691 and 82170819)+4 种基金Shanghai Outstanding Academic Leaders Plan(No.20XD1422800)Shanghai Medical and Health Development Foundation(No.DMRFP_I_01)Clinical Research Plan of SHDC(No.SHDC2020CR3064B)Science and Technology Committee of Shanghai(No.20Y11905100)Key Medical Subject of Jiading District,Shanghai(No.2020-jdyxzdzk-01).
文摘Malnutrition in early life increases the risk of osteoporosis,but the association of early-life undernutrition combined with adulthood obesity patterns with low-energy fracture remains unknown.This study included 5323 community-dwelling subjects aged⩾40 years from China.Early-life famine exposure was identified based on the participants’birth dates.General obesity was assessed using the body mass index(BMI),and abdominal obesity was evaluated with the waist-to-hip ratio(WHR).Low-energy fracture was defined as fracture occurring after the age of⩾40 typically caused by falls from standing height or lower.Compared to the nonexposed group,the group with fetal,childhood,and adolescence famine exposure was associated with an increased risk of fracture in women with odds ratios(ORs)and 95%confidence intervals(CIs)of 3.55(1.57–8.05),3.90(1.57–9.71),and 3.53(1.05–11.88),respectively,but not in men.Significant interactions were observed between fetal famine exposure and general obesity with fracture among women(P for interaction=0.0008).Furthermore,compared with the groups with normal BMI and WHR,the group of women who underwent fetal famine exposure and had both general and abdominal obesity had the highest risk of fracture(OR,95%CI:3.32,1.17–9.40).These results indicate that early-life famine exposure interacts with adulthood general obesity and significantly increases the risk of low-energy fracture later in life in women.
基金financially supported by the framework of the Young Taishan Scholars Program of Shandong Province(No.tsqn.201909026)the Natural Science Foundation of Jiangsu Province(No.BK20200237)+2 种基金the Youth Interdisciplinary Science and Innovative Research Groups of Shandong University(No.2020QNQT014)the Shandong University Future Youth Grant Program(No.61440089964189)the National Natural Science Foundation of China(No.21975084)for their support。
文摘The recombination of photogenerated electrons and holes is a crucial factor limiting photocatalytic H_(2)evolution.The S-scheme ZnWO_(4)-ZnIn_(2)S_(4)heterojunction with 2D coupling interfaces was successfully synthesized using a simple solvothermal method.An effective S-scheme interfacial charge migration route at the S-scheme heterogeneous interface was determined by energy band structure analyses(such as UPS,Mott-Schottky and XPS plots),which facilitates the separation of photoexcited carriers.It is worth noting that the optimal ZnWO_(4)-ZnIn_(2)S_(4)composite has an H_(2)evolution activity of 4925.3μmol g^(-1)h^(-1)with favourable photostability and stability.Meanwhile,the ZnWO_(4)-Zn In_(2)S_(4)heterojunction exhibits the maximum optical response value(2.8 m A cm-2)in the initial stage,effectively promoting the separation and migration of photogenerated carriers.The establishment of the built-in electric field direction at the interface can effectively promote the space charge separation between the ZnWO_(4)and ZnIn_(2)S_(4)nanosheets,which is favorable to the photocatalytic H_(2)evolution.This work provides valuable guidance for designing S-scheme heterojunction photocatalysts composed of two n-type semiconductors for energy and environmental applications.The recombination of photogenerated electrons and holes is a crucial factor limiting photocatalytic H_(2)evolution.The S-scheme ZnWO_(4)-ZnIn_(2)S_(4)heterojunction with 2D coupling interfaces was successfully synthesized using a simple solvothermal method.An effective S-scheme interfacial charge migration route at the S-scheme heterogeneous interface was determined by energy band structure analyses(such as UPS,Mott-Schottky and XPS plots),which facilitates the separation of photoexcited carriers.It is worth noting that the optimal ZnWO_(4)-ZnIn_(2)S_(4)composite has an H_(2)evolution activity of 4925.3μmol g^(-1)h^(-1)with favourable photostability and stability.Meanwhile,the ZnWO_(4)-ZnIn_(2)S_(4)heterojunction exhibits the maximum optical response value(2.8 m A cm-2)in the initial stage,effectively promoting the separation and migration of photogenerated carriers.The establishment of the built-in electric field direction at the interface can effectively promote the space charge separation between the ZnWO_(4)and Zn In_(2)S_(4)nanosheets,which is favorable to the photocatalytic H_(2)evolution.This work provides valuable guidance for designing S-scheme heterojunction photocatalysts composed of two n-type semiconductors for energy and environmental applications.