Jing medicine occupies a very prominent position in the traditional culture of the Chinese nation and has unique advantages. Through the literature review of Jing medicine, the author has a deeper understanding of Jin...Jing medicine occupies a very prominent position in the traditional culture of the Chinese nation and has unique advantages. Through the literature review of Jing medicine, the author has a deeper understanding of Jing medicine in Guangxi. This paper mainly shows the traditional characteristic medicine culture of the Jing nationality and discusses the characteristic therapy and medication characteristics of Jing nationality medicine, which is conducive to the improvement of people’s cognition of Jing nationality medicine and the development and innovation of Jing nationality medicine.展开更多
Background Deoxynivalenol(DON)is a widespread issue for feed and food safety,leading to animal and human health risks.The objective of this study was to determine whether ferroptosis is involved in DON-induced intesti...Background Deoxynivalenol(DON)is a widespread issue for feed and food safety,leading to animal and human health risks.The objective of this study was to determine whether ferroptosis is involved in DON-induced intestinal injury in piglets.Three groups of 21-day-old male weanling piglets(n 4,serum and small intestines were=7/group)were fed a control diet,or diet adding 1.0 or 3.0 mg DON/kg.At week collected to assay for biochemistry,histology,redox status and ferroptosis-related genes expression.In addition,the involvement of ferroptosis and the role of FTL gene in DON-induced cell death were further verified in the IPEC-J2 cells.Results Compared to the control,dietary supplementation of DON at 1.0 and 3.0 mg/kg induced different degrees of damage in the duodenum,jejunum and ileum,and increased(P<0.05)serum lipopolysaccharide concentration by 46.2%-51.4%.Dietary DON supplementation at 1.0 and(or)3.0 mg/kg increased(P<0.05)concentrations of malondialdehyde(17.4%-86.5%)and protein carbonyl by 33.1%-92.3%in the duodenum,jejunum and ileum.In addition,dietary supplemented with DON upregulated(P<0.05)ferroptotic gene(DMT1)and anti-ferroptotic genes(FTL and FTH1),while downregulated(P<0.05)anti-ferroptotic genes(FPN,FSP1 and CISD1)in the duodenum of the porcine.Furthermore,the in vitro study has demonstrated that deferiprone,a potent ferroptotic inhibitor,mitigated(P<0.05)DON-induced cytotoxicity in porcine small intestinal IPEC-J2 cells.Additionally,deferiprone prevented or alleviated(P<0.05)the dysregulation of ferroptosis-related genes(ACSL4 and FTL)by DON in IPEC-J2 cells.Moreover,specific siRNA knockdown FTL gene expression compromised the DON-induced cell death in IPEC-J2 cells.Conclusions In conclusion,this study revealed that ferroptosis is involved in DON-induced intestinal damage in porcine,and sheds a new light on the toxicity of DON to piglets.展开更多
Layered LiCoO_(2)(LCO)acts as a dominant cathode material for lithium-ion batteries(LIBs)in 3C products because of its high compacted density and volumetric energy density.Although improving the high cutoff voltage is...Layered LiCoO_(2)(LCO)acts as a dominant cathode material for lithium-ion batteries(LIBs)in 3C products because of its high compacted density and volumetric energy density.Although improving the high cutoff voltage is an effective strategy to increase its capacity,such behavior would trigger rapid capacity decay due to the surface or/and structure degradation.Herein,we propose a bi-functional surface strategy involving constructing a robust spinel-like phase coating layer with great integrity and compatibility to LiCoO_(2) and modulating crystal lattice by anion and cation gradient co-doping at the subsurface.As a result,the modified LiCoO_(2)(AFM-LCO)shows a capacity retention of 80.9%after 500 cycles between 3.0and 4.6 V.The Al,F,Mg enriched spinel-like phase coating layer serves as a robust physical barrier to effectively inhibit the undesired side reactions between the electrolyte and the cathode.Meanwhile,the Al,F,Mg gradient co-doping significantly enhances the surficial structure stability,suppresses Co dissolution and oxygen release,providing a stable path for Li-ions mobility all through the long-term cycles.Thus,the surface bi-functional strategy is an effective method to synergistically improve the electrochemical performances of LCO at a high cut-off voltage of 4.6 V.展开更多
Growing evidence suggests that the presence of cancer stem cells(CSCs)is a major challenge in current tumor treatments,especially the transition from non-CSCs to differentiation of CSCs for evading conventional therap...Growing evidence suggests that the presence of cancer stem cells(CSCs)is a major challenge in current tumor treatments,especially the transition from non-CSCs to differentiation of CSCs for evading conventional therapies and driving metastasis.Here we propose a therapeutic strategy of synergistic differentiation therapy and phototherapy to induce differentiation of CSCs into mature tumor cells by differentiation inducers and synergistic elimination of them and normal cancer cells through phototherapy.In this work,we synthesized a biomimetic nanoplatform loaded with IR-780 and all-trans retinoic acid(ATRA)via biomineralization.This method can integrate aluminum ions into small-sized protein carriers to form nanoclusters,which undergo responsive degradation under acidic conditions and facilitate deep tumor penetration.With the help of CSC differentiation induced by ATRA,IR-780 inhibited the self-renewal of CSCs and cancer progression by generating hyperthermia and reactive oxygen species in a synergistic manner.Furthermore,ATRA can boost immunogenic cell death induced by phototherapy,thereby strongly causing a systemic anti-tumor immune response and efficiently eliminating CSCs and tumor cells.Taken together,this dual strategy represents a new paradigm of targeted eradication of CSCs and tumors by inducing CSC differentiation,improving photothermal therapy/photodynamic therapy and enhancing antitumor immunity.展开更多
Laser-driven ion accelerators have the advantages of compact size,high density,and short bunch duration over conventional accelerators.Nevertheless,it is still challenging to generate ion beams with quasi-monoenergeti...Laser-driven ion accelerators have the advantages of compact size,high density,and short bunch duration over conventional accelerators.Nevertheless,it is still challenging to generate ion beams with quasi-monoenergetic peak and low divergence in experiments with the current ultrahigh intensity laser and thin target technologies.Here we propose a scheme that a Laguerre–Gaussian laser irradiates a near-critical-density(NCD)plasma to generate a quasi-monoenergetic and low-divergence proton beam.The Laguerre–Gaussian laser pulse in an NCD plasma excites a moving longitudinal electrostatic field with a large amplitude,and it maintains the inward bowl-shape for dozens of laser durations.This special distribution of the longitudinal electrostatic field can simultaneously accelerate and converge the protons.Our particle-in-cell(PIC)simulation shows that the efficient proton acceleration can be realized with the Laguerre–Gaussian laser intensity ranging from 3.9×10^(21)W·cm^(-2)–1.6×10^(22)W·cm^(-2)available in the near future,e.g.,a quasi-monoenergetic proton beam with peak energy~115 MeV and divergence angles less than 5°can be generated by a 5.3×10^(21)W·cm^(-2)pulse.This work could provide a reference for the high-quality ion beam generation with PWclass laser systems available recently.展开更多
The integrity and fineness characterization of non-connected regions and contours is a major challenge for existing salient object detection.The key to address is how to make full use of the subjective and objective s...The integrity and fineness characterization of non-connected regions and contours is a major challenge for existing salient object detection.The key to address is how to make full use of the subjective and objective structural information obtained in different steps.Therefore,by simulating the human visual mechanism,this paper proposes a novel multi-decoder matching correction network and subjective structural loss.Specifically,the loss pays different attentions to the foreground,boundary,and background of ground truth map in a top-down structure.And the perceived saliency is mapped to the corresponding objective structure of the prediction map,which is extracted in a bottom-up manner.Thus,multi-level salient features can be effectively detected with the loss as constraint.And then,through the mapping of improved binary cross entropy loss,the differences between salient regions and objects are checked to pay attention to the error prone region to achieve excellent error sensitivity.Finally,through tracking the identifying feature horizontally and vertically,the subjective and objective interaction is maximized.Extensive experiments on five benchmark datasets demonstrate that compared with 12 state-of-the-art methods,the algorithm has higher recall and precision,less error and strong robustness and generalization ability,and can predict complete and refined saliency maps.展开更多
文摘Jing medicine occupies a very prominent position in the traditional culture of the Chinese nation and has unique advantages. Through the literature review of Jing medicine, the author has a deeper understanding of Jing medicine in Guangxi. This paper mainly shows the traditional characteristic medicine culture of the Jing nationality and discusses the characteristic therapy and medication characteristics of Jing nationality medicine, which is conducive to the improvement of people’s cognition of Jing nationality medicine and the development and innovation of Jing nationality medicine.
基金partially supported by the National Key Research and Development Program of ChinaProjects(2016YFD0501207 and 2018YFD0500601)a donation from Jiangsu Aomai Bio-technology Co.,Ltd。
文摘Background Deoxynivalenol(DON)is a widespread issue for feed and food safety,leading to animal and human health risks.The objective of this study was to determine whether ferroptosis is involved in DON-induced intestinal injury in piglets.Three groups of 21-day-old male weanling piglets(n 4,serum and small intestines were=7/group)were fed a control diet,or diet adding 1.0 or 3.0 mg DON/kg.At week collected to assay for biochemistry,histology,redox status and ferroptosis-related genes expression.In addition,the involvement of ferroptosis and the role of FTL gene in DON-induced cell death were further verified in the IPEC-J2 cells.Results Compared to the control,dietary supplementation of DON at 1.0 and 3.0 mg/kg induced different degrees of damage in the duodenum,jejunum and ileum,and increased(P<0.05)serum lipopolysaccharide concentration by 46.2%-51.4%.Dietary DON supplementation at 1.0 and(or)3.0 mg/kg increased(P<0.05)concentrations of malondialdehyde(17.4%-86.5%)and protein carbonyl by 33.1%-92.3%in the duodenum,jejunum and ileum.In addition,dietary supplemented with DON upregulated(P<0.05)ferroptotic gene(DMT1)and anti-ferroptotic genes(FTL and FTH1),while downregulated(P<0.05)anti-ferroptotic genes(FPN,FSP1 and CISD1)in the duodenum of the porcine.Furthermore,the in vitro study has demonstrated that deferiprone,a potent ferroptotic inhibitor,mitigated(P<0.05)DON-induced cytotoxicity in porcine small intestinal IPEC-J2 cells.Additionally,deferiprone prevented or alleviated(P<0.05)the dysregulation of ferroptosis-related genes(ACSL4 and FTL)by DON in IPEC-J2 cells.Moreover,specific siRNA knockdown FTL gene expression compromised the DON-induced cell death in IPEC-J2 cells.Conclusions In conclusion,this study revealed that ferroptosis is involved in DON-induced intestinal damage in porcine,and sheds a new light on the toxicity of DON to piglets.
基金supported by the National Natural Science Foundation of China(22075170,52072233)the Beijing National Laboratory for Condensed Matter Physics。
文摘Layered LiCoO_(2)(LCO)acts as a dominant cathode material for lithium-ion batteries(LIBs)in 3C products because of its high compacted density and volumetric energy density.Although improving the high cutoff voltage is an effective strategy to increase its capacity,such behavior would trigger rapid capacity decay due to the surface or/and structure degradation.Herein,we propose a bi-functional surface strategy involving constructing a robust spinel-like phase coating layer with great integrity and compatibility to LiCoO_(2) and modulating crystal lattice by anion and cation gradient co-doping at the subsurface.As a result,the modified LiCoO_(2)(AFM-LCO)shows a capacity retention of 80.9%after 500 cycles between 3.0and 4.6 V.The Al,F,Mg enriched spinel-like phase coating layer serves as a robust physical barrier to effectively inhibit the undesired side reactions between the electrolyte and the cathode.Meanwhile,the Al,F,Mg gradient co-doping significantly enhances the surficial structure stability,suppresses Co dissolution and oxygen release,providing a stable path for Li-ions mobility all through the long-term cycles.Thus,the surface bi-functional strategy is an effective method to synergistically improve the electrochemical performances of LCO at a high cut-off voltage of 4.6 V.
基金supported by National Science and Technology Major Special Project-Major New Drug Creation(2019ZX09301-112)Shandong Natural Science Foundation(ZR2020QH351)+1 种基金Shandong Provincial Program of Taishan Industrial Experts(2019TSCYCX-31)the Fundamental Research Funds of Shandong University(2020GN091)
文摘Growing evidence suggests that the presence of cancer stem cells(CSCs)is a major challenge in current tumor treatments,especially the transition from non-CSCs to differentiation of CSCs for evading conventional therapies and driving metastasis.Here we propose a therapeutic strategy of synergistic differentiation therapy and phototherapy to induce differentiation of CSCs into mature tumor cells by differentiation inducers and synergistic elimination of them and normal cancer cells through phototherapy.In this work,we synthesized a biomimetic nanoplatform loaded with IR-780 and all-trans retinoic acid(ATRA)via biomineralization.This method can integrate aluminum ions into small-sized protein carriers to form nanoclusters,which undergo responsive degradation under acidic conditions and facilitate deep tumor penetration.With the help of CSC differentiation induced by ATRA,IR-780 inhibited the self-renewal of CSCs and cancer progression by generating hyperthermia and reactive oxygen species in a synergistic manner.Furthermore,ATRA can boost immunogenic cell death induced by phototherapy,thereby strongly causing a systemic anti-tumor immune response and efficiently eliminating CSCs and tumor cells.Taken together,this dual strategy represents a new paradigm of targeted eradication of CSCs and tumors by inducing CSC differentiation,improving photothermal therapy/photodynamic therapy and enhancing antitumor immunity.
基金Project supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDA25050300)the National Natural Science Foundation of China(Grant No.12205366)+2 种基金the National Key Research and Development Program of China(Grant No.2018YFA0404801)the Fundamental Research Funds for the Central Universities(Grant No.2020MS138)the Research Funds of Renmin University of China(Grant No.20XNLG01)。
文摘Laser-driven ion accelerators have the advantages of compact size,high density,and short bunch duration over conventional accelerators.Nevertheless,it is still challenging to generate ion beams with quasi-monoenergetic peak and low divergence in experiments with the current ultrahigh intensity laser and thin target technologies.Here we propose a scheme that a Laguerre–Gaussian laser irradiates a near-critical-density(NCD)plasma to generate a quasi-monoenergetic and low-divergence proton beam.The Laguerre–Gaussian laser pulse in an NCD plasma excites a moving longitudinal electrostatic field with a large amplitude,and it maintains the inward bowl-shape for dozens of laser durations.This special distribution of the longitudinal electrostatic field can simultaneously accelerate and converge the protons.Our particle-in-cell(PIC)simulation shows that the efficient proton acceleration can be realized with the Laguerre–Gaussian laser intensity ranging from 3.9×10^(21)W·cm^(-2)–1.6×10^(22)W·cm^(-2)available in the near future,e.g.,a quasi-monoenergetic proton beam with peak energy~115 MeV and divergence angles less than 5°can be generated by a 5.3×10^(21)W·cm^(-2)pulse.This work could provide a reference for the high-quality ion beam generation with PWclass laser systems available recently.
基金supported by the National Natural Science Foundation of China(No.52174021)Key Research and Develop-ment Project of Hainan Province(No.ZDYF2022GXJS 003).
文摘The integrity and fineness characterization of non-connected regions and contours is a major challenge for existing salient object detection.The key to address is how to make full use of the subjective and objective structural information obtained in different steps.Therefore,by simulating the human visual mechanism,this paper proposes a novel multi-decoder matching correction network and subjective structural loss.Specifically,the loss pays different attentions to the foreground,boundary,and background of ground truth map in a top-down structure.And the perceived saliency is mapped to the corresponding objective structure of the prediction map,which is extracted in a bottom-up manner.Thus,multi-level salient features can be effectively detected with the loss as constraint.And then,through the mapping of improved binary cross entropy loss,the differences between salient regions and objects are checked to pay attention to the error prone region to achieve excellent error sensitivity.Finally,through tracking the identifying feature horizontally and vertically,the subjective and objective interaction is maximized.Extensive experiments on five benchmark datasets demonstrate that compared with 12 state-of-the-art methods,the algorithm has higher recall and precision,less error and strong robustness and generalization ability,and can predict complete and refined saliency maps.
