辽宁航运服务现状分析及能力提升策略研究

近年来,国家高度注重航运企业服务能力建设,航运服务业开放性发展程度进一步提升。辽宁航运服务业以基础航运服务为主,高端航运服务能力不足。文章分析了辽宁航运服务现状,针对服务能级较低、航运高端人才匮乏、航运服务评价体系不完善等方面提出建议、对策,以提升辽宁国际航运服务能力。

NIR-Ⅱ photothermal therapy for effective tumor eradication enhanced by heterogeneous nanorods with dual catalytic activities

Rational design and exploitation of nanomaterials with superior treatment properties for suitable indications is a way out to relieve cost constraint of therapy and solve the unsatisfactory efficacy for cancer patients.In this work,we propose a greatly facile approach to produce heterogeneous Pd-Au nanorods(Pd-Au NRs)that solve the current bottleneck problems of photothermal thermal therapy(PTT)as well as completely eliminate tumors in animal models without toxic side effects.Depositing Pd clusters on both tips of Au NRs offers Pd-Au NRs three novel functions,i.e.,the extension of the absorption into NIR-Ⅱ region,the activation of prodrug of 5-fluorouracil(5-Fu)via the bioorthogonal reaction,and the peroxidase-mimic activity to produce·OH.The heterogeneous nanorods showed a high and stable photothermal conversion efficiency(52.07%)in a safer NIR-Ⅱ irradiation region(1,064 nm),which not only eliminate most of tumor cells at only one dose of the irradiation for 5 min but also improve the in situ conversion of 5-fluoro-1-propargyluracil and H2O2 into active 5-Fu and·OH to eradicate residual tumors for inhibiting tumor metastasis.This dual catalytic activity-synergistic mechanism of PTT demonstrates the importance of material design in solving current bottleneck problem of tumor therapy.

Unmodified methodologies in target discovery for small molecule drugs:A rising star

Target discovery,involving target identification and validation,is the prerequisite for drug discovery and screening.Novel methodologies and technologies for the precise discovery and confirmation of drug targets are powerful tools in understanding the disease,looking for a drug and elucidating the mechanism of drug treatment.Among the common target identification and confirmation methods,the modified method is time-consuming and laborious,which may reduce or change the activity of natural products.The unmodified methods developed in recent years without chemical modification have gradually become an important means of studying drug targets.A wide range of unmodified approaches have been reported,introducing and analyzing the recent emerging methodologies and technologies.This review highlights the advantages and limitations of these methods for the application of drug target discovery and presents an overview of their contributions to the target discovery of small molecule drugs.The application and future development trends of methodologies in target discovery are also prospected to provide a reference for drug target research.

Joint Bidding Decision of Wind Farms and Energy Storage Based on Newsvendor Model

Currently,renewable energy generation has received more and more attention.This article focuses on wind energy generation,one of the renewable energy sources.Aiming at the intermittent and unpredictable wind power problems,according to the day ahead bidding mechanism in the power market,this paper introduces the energy storage system to maximize wind power merchants profit based on the newsvendor model.First,this paper focuses on the wind farms combined with storage system to put forward the optimal bidding decision of selling or buying electricity to the market one day in advance and the optimal bidding amount.Then,we analyze the relationship between the optimal bid amount and the market penalty price coefficient,government subsidy,storage system charge and discharge efficiency,and other parameters.Based on the analysis of various parameters,power generation companies can make reasonable bidding decisions and amount to maximize profits.