Metformin administration in prevention of colorectal polyps in type 2 diabetes mellitus patients

BACKGROUND Colorectal polyps are frequently observed in patients with type 2 diabetes mellitus(DM),posing a significant risk for colorectal cancer.Metformin,a widely prescribed biguanidine drug for type 2 DM,has been suggested to have potential chemoprophylactic effects against various cancers.AIM To explore the correlation between colorectal polyps and metformin use in type 2 DM patients.METHODS Type 2 DM patients were categorized into polyp and non-polyp groups.Following this,all patients were categorized into the type 2 DM-metformin,type 2 DM-non-metformin,and non-type 2 DM groups.Based on the baseline colonoscopy results,we performed pairwise comparisons of the incidence of colorectal polyps among the three groups.Additionally,we analyzed the relationship between colorectal polyps and the duration of metformin use and between the size and number of polyps and metformin use.Simultaneously,we focused on the specific pathological types of polyps and analyzed their relationship with metformin use.Finally,we compared the incidence of polyps between metformin and non-metformin groups according to the interval colonoscopy results.RESULTS The rate of metformin use in patients with colorectal polyps was 0.502 times that of patients without colorectal polyps[odds ratio(OR)=0.502,95%confidence interval(CI):0.365-0.689;P<0.001].The incidence of colorectal polyps did not differ significantly between the type 2 DM-metformin and non-type 2 DM groups(P>0.05).Furthermore,the correlations between the duration of metformin use and the incidence of colorectal polyps and between the size and number of polyps and metformin use were not statistically significant(P>0.05).Metformin use did not affect the incidence of colorectal polyps during interval colonoscopy(P>0.05).CONCLUSION Metformin use and colorectal polyp incidence in type 2 DM patients showed a negative correlation,independent of the hypoglycemic effect of metformin.

一种基于遗传算法的钣金零件排样算法（英文）

钣金类零件是通过压力成形技术制造的一种应用广泛的零件,现今钣金件的数字化制造手段日益广泛。钣金工艺设计是钣金设计和制造之间的重要连接环节,科学合理的工艺是生产优良产品的重要因素。但钣金产品的工艺设计水平却远远落后于其设计和制造水平,成为了制约产品质量和成品的瓶颈。本文以一种复杂的锂电池箱体为例,对钣金件的数字化制造进行研究。首先提出了钣金件数字化集成制造的总体流程,研究了钣金件的设计、展开、板材的排样、激光切割、数控冲压和折弯等技术,实现了锂电池钣金箱体的集成制造。

圆弧螺纹与普通螺纹锚栓防松性能研究

针对圆弧螺纹和普通螺纹的锚栓组件,分析了螺纹结构差异,并对螺纹连接松动机理进行了分析。基于有限元方法,计算了不同预紧力栽荷、横向位移栽荷条件下,圆弧螺纹锚栓和普通螺纹锚栓残余预紧力变化情况。结果表明,螺纹连接副在承受横向位移循环栽荷螺母发生松动时,圆弧螺纹锚栓残余预紧力下降可分为快速下降和平稳阶段,且在平稳阶段预紧力下降速度极为缓慢,而普通螺纹锚栓残余预紧力的变化趋势呈线性变化,没有明显的阶梯性,而且圆弧螺纹锚栓残余预紧力下降速度始终低于普通螺纹锚栓,故圆弧螺纹锚栓的综合防松效果要优于普遍螺纹锚栓。