An electrochemical defluorinative alkylation protocol ofα-trifluoromethyl alkenes is described.This reaction enables the preparation of functionalized gem-difluoroalkenes with the use of diverse alkyl sources includi...An electrochemical defluorinative alkylation protocol ofα-trifluoromethyl alkenes is described.This reaction enables the preparation of functionalized gem-difluoroalkenes with the use of diverse alkyl sources including organohalides,N-hydroxyphthalimide(NHP)esters and Katritzky salts.This method exhibits lots of synthetic advantages including mild conditions,simple operation,and convenience of amplification,and provides a new route for the synthesis of gem-difluoroalkenes。展开更多
基金the National Natural Science Foundation of China(no.21672047 and 22101066)the State Key Laboratory of Urban Water Resource and Environment(no.2018DX02)+3 种基金the Science and Technology Plan of Shenzhen(JCYJ20210324133001004)the Natural Science Foundation of Guangdong(no.2020A1515010564)the Guangdong Province Covid-19 Pandemic Control Research Fund(no.2020KZDZX1218)supported by the Open Research Fund of the School of Chemistry and Chemical Engineering,Henan Normal University.
文摘An electrochemical defluorinative alkylation protocol ofα-trifluoromethyl alkenes is described.This reaction enables the preparation of functionalized gem-difluoroalkenes with the use of diverse alkyl sources including organohalides,N-hydroxyphthalimide(NHP)esters and Katritzky salts.This method exhibits lots of synthetic advantages including mild conditions,simple operation,and convenience of amplification,and provides a new route for the synthesis of gem-difluoroalkenes。
