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色氨酸代谢在炎症性肠病中的研究进展
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作者 李梦琳 孙少鹏 +2 位作者 孙可 吕宾 范一宏 《世界华人消化杂志》 CAS 2023年第21期896-903,共8页
炎症性肠病(inflammatory bowel disease,IBD)包括溃疡性结肠炎和克罗恩病,其发病机制与肠道菌群紊乱密切相关.肠道菌群紊乱导致的肠道微环境异常影响氨基酸的代谢.色氨酸作为人体必需氨基酸,其代谢产物参与调节免疫、神经元功能和肠道... 炎症性肠病(inflammatory bowel disease,IBD)包括溃疡性结肠炎和克罗恩病,其发病机制与肠道菌群紊乱密切相关.肠道菌群紊乱导致的肠道微环境异常影响氨基酸的代谢.色氨酸作为人体必需氨基酸,其代谢产物参与调节免疫、神经元功能和肠道稳态等.IBD疾病的发生与发展伴随色氨酸的缺乏或代谢异常.本综述主要介绍了肠道菌群代谢物色氨酸及其代谢产物与IBD疾病发生与发展之间的关系,并为未来预测IBD疾病活动的诊断方法和治疗IBD的方案提供了新思路. 展开更多
关键词 炎症性肠病 肠道菌群 色氨酸 芳烃受体 犬尿氨酸途径 5-羟色胺
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炎症性肠病常见心理问题及管理 被引量:1
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作者 李梦琳 范一宏 《世界华人消化杂志》 CAS 2022年第8期370-374,共5页
炎症性肠病(inflammatory bowel disease,IBD)患者心理问题的发生率显著高于普通人群,其中常见的心理问题有焦虑和抑郁.这些心理问题会对IBD患者的生活质量和疾病预后产生不利影响,而低生活质量和复杂的病程同时也会加重患者的焦虑和抑... 炎症性肠病(inflammatory bowel disease,IBD)患者心理问题的发生率显著高于普通人群,其中常见的心理问题有焦虑和抑郁.这些心理问题会对IBD患者的生活质量和疾病预后产生不利影响,而低生活质量和复杂的病程同时也会加重患者的焦虑和抑郁,其中脑-肠轴的紊乱是IBD疾病活动与心理问题双向影响的重要机制.IBD患者心理状态的评估和规范化管理日益受到重视.本文对IBD患者常见的心理问题,及其与IBD疾病活动之间的相互作用,以及IBD患者心理问题的管理进行了综述. 展开更多
关键词 炎症性肠病 心理问题 脑-肠轴 心理评估 心理治疗
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High dimensional proteomic mapping of bone marrow immune characteristics in immune thrombocytopenia
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作者 Feng-Qi liu Qing-Yuan Qu +12 位作者 Ying Lei Qi Chen Yu-Xiu Chen meng-lin li Xue-Yan Sun Ye-Jun Wu Qiu-Sha Huang Hai-Xia Fu Yuan Kong Yue-Ying li Qian-Fei Wang Xiao-Jun Huang Xiao-Hui Zhang 《Science China(Life Sciences)》 SCIE CAS CSCD 2024年第8期1635-1647,共13页
To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia(ITP),this study mapped the immune cell heterogeneity in the bone marrow of ITP at the single-cell le... To investigate the role of co-stimulatory and co-inhibitory molecules on immune tolerance in immune thrombocytopenia(ITP),this study mapped the immune cell heterogeneity in the bone marrow of ITP at the single-cell level using Cytometry by Time of Flight(CyTOF).Thirtysix patients with ITP and nine healthy volunteers were enrolled in the study.As soluble immunomodulatory molecules,more sCD25 and sGalectin-9 were detected in ITP patients.On the cell surface,co-stimulatory molecules like ICOS and HVEM were observed to be upregulated in mainly central memory and effector T cells.In contrast,co-inhibitory molecules such as CTLA-4 were significantly reduced in Th1 and Th17 cell subsets.Taking a platelet count of 30×10^(9)L^(−1)as the cutoff value,ITP patients with high and low platelet counts showed different T cell immune profiles.Antigen-presenting cells such as monocytes and B cells may regulate the activation of T cells through CTLA-4/CD86 and HVEM/BTLA interactions,respectively,and participate in the pathogenesis of ITP.In conclusion,the proteomic and soluble molecular profiles brought insight into the interaction and modulation of immune cells in the bone marrow of ITP.They may offer novel targets to develop personalized immunotherapies. 展开更多
关键词 immune thrombocytopenia autoimmune diseases co-stimulatory co-inhibitory immune checkpoint CTLA4 Cytometry by Time of Flight bone marrow
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Characterization of Acidic Glycosphingolipid Changes in C6 Glioma Rats Treated With Temozolomide Using Ultra-High-Performance Liquid Chromatography Coupled With Quadrupole Time-of-Flight Mass Spectrometry
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作者 Tian-Kun Ren meng-lin li +2 位作者 Hao Zheng Zhe Wang Jin-Lan Zhang 《Journal of Analysis and Testing》 EI 2020年第3期217-225,共9页
Ganglioside and sulfatide are primary components of acidic glycosphingolipids(AGSLs),which are abundant in the brain tissue.AGSLs are potential tumor markers.In this paper,we use ultra-high performance liquid chromato... Ganglioside and sulfatide are primary components of acidic glycosphingolipids(AGSLs),which are abundant in the brain tissue.AGSLs are potential tumor markers.In this paper,we use ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry to generate a first-ever comprehensive profile of AGSLs in brain and plasma of C6 glioma rats treated with temozolomide(TMZ).The AGSLs detected consisted mainly of C18-/C20-sphingosine.12,20,19,14 and 12 species were identified in GM1,GD1a,GD1b,GM3 and GT1b ganglioside groups which were abundant in rat brain,respectively.These five groups accounted for 88-89%of total ganglioside content.However,no AGSLs were detected in rat plasma.Possible biomarkers for abnormal changes in the glioma model and the protective effect of TMZ were mainly found in these ganglioside groups and sulfatide.The main lipid component of central and peripheral nervous system myelin sheathes is sulfatide,which is upregulated in many tumors.Antitumor properties of TMZ are due to modulation of sulfatide levels in tumor tissues. 展开更多
关键词 Acidic glycosphingolipids TEMOZOLOMIDE C6 glioma UPLC-QTOF-MS
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Healthcare simulation in China: current status and perspectives 被引量:1
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作者 meng-lin li Gang Wang Jian-Ping Lyu 《Chinese Medical Journal》 SCIE CAS CSCD 2019年第20期2503-2504,共2页
To the Editor: The issue of patient safety has been making headlines continuously. China is facing the same patient safety problem. According to the statistical report of 2014 to 2015 medical disputes, in many large c... To the Editor: The issue of patient safety has been making headlines continuously. China is facing the same patient safety problem. According to the statistical report of 2014 to 2015 medical disputes, in many large cities of China, for example, Beijing and Shanghai, patient death is mainly caused by lack of standards in the medical treatment and operational procedures.[1] Implementation of simulation-based healthcare training could be a potential solution to standardize the medical procedures. However, healthcare simulation in China is still facing great challenges for the moment. 展开更多
关键词 problem. continuously FACING
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