Objective:To prepare the liposomes of mangrove oil,Optimization of the formulation of mangrove oil liposomes by Box Behnken response surface methodology.Methods:Preparation of Rhododendron oil liposomes by ethanol inj...Objective:To prepare the liposomes of mangrove oil,Optimization of the formulation of mangrove oil liposomes by Box Behnken response surface methodology.Methods:Preparation of Rhododendron oil liposomes by ethanol injection probe ultrasound,Determination of gemacrone by HPLC.The ratio of lecithin to cholesterol(X1),drug lipid ratio(X2)and phospholipid concentration(X3)were used as independent variables,and encapsulation efficiency(Y)was used as dependent variable,the formulation was optimized by Box Behnken response surface method,and the entrapment efficiency was predicted.The entrapment efficiency,particle size,polydispersity index(PDI),Zeta potential and drug loading of the optimized liposomes were evaluated.Results:The optimal prescription and preparation of Folium Rhododendri Daurici oil liposome was confirmed as follows:X1=7.28:1、X2=11.34:1、X3=9.32mg·mL-1,the encapsulation efficiency was(82.55±1.66)%,the particle size was(130.531±46)nm,the polydispersity index was 0.185±05,Zeta potential was(21.970±36)mV,the drug loading was(5.941±0.12)%.Conclusion:The Box Behnken response surface method is accurate to obtain the optimal formulation of mangrove oil liposomes,it has high precision and good prediction effect.And the preparation process of mangrove oil liposomes is stable and feasible.展开更多
Dear Editor,Tuberculosis(TB)is a significant cause of morbidity and mortality in developing countries,with a global burden of∼10.0 million cases in 2019.China accounts for 8.4%of TB cases globally,ranking third after...Dear Editor,Tuberculosis(TB)is a significant cause of morbidity and mortality in developing countries,with a global burden of∼10.0 million cases in 2019.China accounts for 8.4%of TB cases globally,ranking third after India and Indonesia[1].Abdominal TB is a common extrapulmonary manifestation,often presenting as lymphadenopathy.Accurate differentiation between abdominal tuberculosis lymphadenopathy(ATBL)and lymphoma holds significance for treatment decisions and prognosis.展开更多
基金Heilongjiang Province North Medicine and Functional Food Characteristic Discipline Construction Project(No.2018-TSXK-02)Heilongjiang Provincial Department of Education Project(No.12511574)。
文摘Objective:To prepare the liposomes of mangrove oil,Optimization of the formulation of mangrove oil liposomes by Box Behnken response surface methodology.Methods:Preparation of Rhododendron oil liposomes by ethanol injection probe ultrasound,Determination of gemacrone by HPLC.The ratio of lecithin to cholesterol(X1),drug lipid ratio(X2)and phospholipid concentration(X3)were used as independent variables,and encapsulation efficiency(Y)was used as dependent variable,the formulation was optimized by Box Behnken response surface method,and the entrapment efficiency was predicted.The entrapment efficiency,particle size,polydispersity index(PDI),Zeta potential and drug loading of the optimized liposomes were evaluated.Results:The optimal prescription and preparation of Folium Rhododendri Daurici oil liposome was confirmed as follows:X1=7.28:1、X2=11.34:1、X3=9.32mg·mL-1,the encapsulation efficiency was(82.55±1.66)%,the particle size was(130.531±46)nm,the polydispersity index was 0.185±05,Zeta potential was(21.970±36)mV,the drug loading was(5.941±0.12)%.Conclusion:The Box Behnken response surface method is accurate to obtain the optimal formulation of mangrove oil liposomes,it has high precision and good prediction effect.And the preparation process of mangrove oil liposomes is stable and feasible.
基金supported by the Sichuan Province Science and Technology Support Program (Grant No.2020YFS0120).
文摘Dear Editor,Tuberculosis(TB)is a significant cause of morbidity and mortality in developing countries,with a global burden of∼10.0 million cases in 2019.China accounts for 8.4%of TB cases globally,ranking third after India and Indonesia[1].Abdominal TB is a common extrapulmonary manifestation,often presenting as lymphadenopathy.Accurate differentiation between abdominal tuberculosis lymphadenopathy(ATBL)and lymphoma holds significance for treatment decisions and prognosis.