BACKGROUND Treatment for neck lymph node metastases after adequate initial surgery in medullary thyroid carcinoma(MTC)has been controversial.Ultrasound(US)-guided radiofrequency ablation(RFA)has been widely used in re...BACKGROUND Treatment for neck lymph node metastases after adequate initial surgery in medullary thyroid carcinoma(MTC)has been controversial.Ultrasound(US)-guided radiofrequency ablation(RFA)has been widely used in recurrent welldifferentiated thyroid carcinoma.Here,we report for the first time the use of RFA in a patient with recurrent MTC.CASE SUMMARY We report the case of a 56-year-old woman with cervical lymph node metastases of MTC.Four years previously,she had undergone a total thyroidectomy and neck lymph node dissection.A neck US revealed many enlarged nodes during the follow-up period.Moreover,the serum calcitonin jumped to 198.17 pg/mL,which strongly indicated the recurrence of MTC.Subsequently,two metastatic lymph nodes were confirmed by US-guided fine-needle aspiration-cytology and fineneedle aspiration-calcitonin,and then the patient was treated with RFA.Four months later,the neck US and a contrast-enhanced US showed obvious shrinkage in the ablation zones,and the serum calcitonin dropped to 11.80 pg/mL.CONCLUSION This case suggests that RFA may be an effective and safe treatment for local recurrent MTC.展开更多
To the Editor:Many well-studied sonographic features have been used clinically to evaluate thyroid nodules for malignancies.Sonographic grayscale features proposed by the American College of Radiology Thyroid Imaging,...To the Editor:Many well-studied sonographic features have been used clinically to evaluate thyroid nodules for malignancies.Sonographic grayscale features proposed by the American College of Radiology Thyroid Imaging,Reporting and Data System(TI-RADS)include composition,echogenicity,shape,margin,and echogenic foci.[1]Other features,such as vascularity imaging,have gradually been recognized by sonographers.Sustained angiogenesis results in tumor-specific vasculature compared to normal tissues in the context of architecture and biological behavior.[2]Tumor neovascularization shows abnormal maturation,manifesting irregular sprouting,and branching of angiogenic vessels with disordered coverage of pericytes.Therefore,vascularity is critical for the evaluation of malignancy in thyroid nodules.展开更多
文摘BACKGROUND Treatment for neck lymph node metastases after adequate initial surgery in medullary thyroid carcinoma(MTC)has been controversial.Ultrasound(US)-guided radiofrequency ablation(RFA)has been widely used in recurrent welldifferentiated thyroid carcinoma.Here,we report for the first time the use of RFA in a patient with recurrent MTC.CASE SUMMARY We report the case of a 56-year-old woman with cervical lymph node metastases of MTC.Four years previously,she had undergone a total thyroidectomy and neck lymph node dissection.A neck US revealed many enlarged nodes during the follow-up period.Moreover,the serum calcitonin jumped to 198.17 pg/mL,which strongly indicated the recurrence of MTC.Subsequently,two metastatic lymph nodes were confirmed by US-guided fine-needle aspiration-cytology and fineneedle aspiration-calcitonin,and then the patient was treated with RFA.Four months later,the neck US and a contrast-enhanced US showed obvious shrinkage in the ablation zones,and the serum calcitonin dropped to 11.80 pg/mL.CONCLUSION This case suggests that RFA may be an effective and safe treatment for local recurrent MTC.
基金a grant from the Natural Science Foundation of Liaoning Province(No.201602221)。
文摘To the Editor:Many well-studied sonographic features have been used clinically to evaluate thyroid nodules for malignancies.Sonographic grayscale features proposed by the American College of Radiology Thyroid Imaging,Reporting and Data System(TI-RADS)include composition,echogenicity,shape,margin,and echogenic foci.[1]Other features,such as vascularity imaging,have gradually been recognized by sonographers.Sustained angiogenesis results in tumor-specific vasculature compared to normal tissues in the context of architecture and biological behavior.[2]Tumor neovascularization shows abnormal maturation,manifesting irregular sprouting,and branching of angiogenic vessels with disordered coverage of pericytes.Therefore,vascularity is critical for the evaluation of malignancy in thyroid nodules.
