Over the past several decades,type 2 diabetes mellitus(T2DM)has been considered a global public health concern.Currently,various therapeutic modalities are available for T2DM management,including dietary modifications...Over the past several decades,type 2 diabetes mellitus(T2DM)has been considered a global public health concern.Currently,various therapeutic modalities are available for T2DM management,including dietary modifications,moderate exercise,and use of hypoglycemic agents and lipid-lowering medications.Although the curative effect of most drugs on T2DM is significant,they also exert some adverse side effects.Biologically active substances found in natural medicines are important for T2DM treatment.Several recent studies have reported that active ingredients derived from traditional medicines or foods exert a therapeutic effect on T2DM.This review compiled important articles regarding the therapeutic effects of natural products and their active ingredients on isletβcell function,adipose tissue inflammation,and insulin resistance.Additionally,this review provided an in-depth understanding of the multiple regulatory effects on different targets and signaling pathways of natural medicines in the treatment of T2DM as well as a theoretical basis for clinical effective application.展开更多
Inflammatory bowel disease(IBD)includes Crohn’s disease and ulcerative colitis and is an idiopathic,chronic inflammatory disease of the colonic mucosa.The occurrence of IBD,causes irreversible damage to the colon and...Inflammatory bowel disease(IBD)includes Crohn’s disease and ulcerative colitis and is an idiopathic,chronic inflammatory disease of the colonic mucosa.The occurrence of IBD,causes irreversible damage to the colon and increases the risk of carcinoma.The routine clinical treatment of IBD includes drug treatment,endoscopic treatment and surgery.The vast majority of patients are treated with drugs and biological agents,but the complete cure of IBD is difficult.Mesenchymal stem cells(MSCs)have become a new type of cell therapy for the treatment of IBD due to their immunomodulatory and nutritional functions,which have been confirmed in many clinical trials.This review discusses some potential mechanisms of MSCs in the treatment of IBD,summarizes the experimental results,and provides new insights to enhance the therapeutic effects of MSCs in future applications.展开更多
基金Supported by the Nature Science Foundation of Hubei Province,No.2023AFB839.
文摘Over the past several decades,type 2 diabetes mellitus(T2DM)has been considered a global public health concern.Currently,various therapeutic modalities are available for T2DM management,including dietary modifications,moderate exercise,and use of hypoglycemic agents and lipid-lowering medications.Although the curative effect of most drugs on T2DM is significant,they also exert some adverse side effects.Biologically active substances found in natural medicines are important for T2DM treatment.Several recent studies have reported that active ingredients derived from traditional medicines or foods exert a therapeutic effect on T2DM.This review compiled important articles regarding the therapeutic effects of natural products and their active ingredients on isletβcell function,adipose tissue inflammation,and insulin resistance.Additionally,this review provided an in-depth understanding of the multiple regulatory effects on different targets and signaling pathways of natural medicines in the treatment of T2DM as well as a theoretical basis for clinical effective application.
基金Supported by the Science and Technology Research Project of Hubei Province,No.2021CFB210.
文摘Inflammatory bowel disease(IBD)includes Crohn’s disease and ulcerative colitis and is an idiopathic,chronic inflammatory disease of the colonic mucosa.The occurrence of IBD,causes irreversible damage to the colon and increases the risk of carcinoma.The routine clinical treatment of IBD includes drug treatment,endoscopic treatment and surgery.The vast majority of patients are treated with drugs and biological agents,but the complete cure of IBD is difficult.Mesenchymal stem cells(MSCs)have become a new type of cell therapy for the treatment of IBD due to their immunomodulatory and nutritional functions,which have been confirmed in many clinical trials.This review discusses some potential mechanisms of MSCs in the treatment of IBD,summarizes the experimental results,and provides new insights to enhance the therapeutic effects of MSCs in future applications.
