Temperature has an important impact on the corrosion resistance of mold with cooling channels prepared by casting method.The effect of preheating temperature of the mold and the carbon fiber core on the roughness and ...Temperature has an important impact on the corrosion resistance of mold with cooling channels prepared by casting method.The effect of preheating temperature of the mold and the carbon fiber core on the roughness and corrosion resistance of U-shaped cooling channels made of Al-12Si alloy was examined in depth.The experimental results suggest that as the preheating temperature increased from 273 K to 573 K,the roughness of the inner wall of the cooling channel reduced from 96.6μm to 77.0μm.When the preheating temperature continued to increase to 723 K,the roughness increased to 85.3μm.The wetting between the Al melt and the carbon fiber will reduce micro bubbles and waves on the channel wall as the preheating temperature rises,thereby reducing the roughness.However,with the further increase of preheating temperature,it will increase the solidification time of the Al melt.At this time,the carbon fiber and Al melt will take more time to react,which increases the roughness of the channel wall to a certain extent.The results of exfoliation corrosion show that the larger roughness will aggravate exfoliation corrosion.The prolongation of high temperature reaction time between the carbon fiber and the Al melt will lead to the segregation of Si,which is easy to cause intergranular corrosion.Therefore,reasonable preheating temperature has an important impact on the roughness and corrosion resistance of U-shaped cooling channels.展开更多
AIM:To investigate changes in macular vessels and thickness in myopic eyes after intraocular collamer lens(ICL)implantation using quantitative optical coherence tomography angiography(OCTA).METHODS:This retrospective ...AIM:To investigate changes in macular vessels and thickness in myopic eyes after intraocular collamer lens(ICL)implantation using quantitative optical coherence tomography angiography(OCTA).METHODS:This retrospective included 73 myopic eyes of 73 patients(average age,27.53±6.16 y)who underwent ICL implantation(28 eyes were Toric ICL).Axial length(AL),uncorrected visual acuity(UCVA),refractive dioptre(RD),intraocular pressure(IOP)and OCTA were measured and compared with before and 1 wk,1,and 3 mo after surgery.OCTA was used to image vessel density(VD)and skeleton density(SD)in both the superficial(SCP)and deep capillary plexus(DCP).Central retinal thickness(CRT)and ganglion cellinner plexiform layer thickness(GCT)were also measured.Changes between pre-and postoperative measurements were analysed by repeated measures analysis of variance.RESULTS:Compared with preoperative data,postoperative data on UCVA revealed significant improvements in all patients(P<0.05).However,there was no significant difference in IOP.After the operation,CRT and GCT exhibited significant changes(P<0.05).Among these measures,CRT was significantly higher at one and three months postoperative(all P<0.01).GCT was significantly higher at 1 wk,1,and 3 mo postoperative(all P<0.01).Changes in VD and SD were nonsignificant in both the SCP and DCP.There was no difference in postoperative changes between the ICL and Toric ICL groups.CONCLUSION:ICL and Toric ICL implantation both have good efficacy and safety for myopic eyes,but macular area changes that occur after surgery need attention.展开更多
This paper reported the impedance-type humidity sensor based on Ti_(3)C_(2)T_(x)/g-C_(3)N_(4)nanomaterials which was fabricated on a flexible polyethylene terephthalate(PET)substrate.The scanning electron microscopy(S...This paper reported the impedance-type humidity sensor based on Ti_(3)C_(2)T_(x)/g-C_(3)N_(4)nanomaterials which was fabricated on a flexible polyethylene terephthalate(PET)substrate.The scanning electron microscopy(SEM),X-ray diffraction(XRD),and X-ray photoelectron spectroscopy(XPS)measurements were used to demonstrate the successful synthesis and combination of Ti_(3)C_(2)T_(x)and g-C_(3)N_(4)nanomaterials.The performance of the humidity sensor was tested at room temperature.The experimental results showed that the Ti_(3)C_(2)T_(x)nanosheets with g-C_(3)N_(4)nanosheets endowed the humidity sensor with an ultra-high response,rapid response/recovery time,and negligible hysteresis.The complex impedance spectroscopy(CIS)and bode diagrams were used to further analyze the sensing mechanism of the Ti_(3)C_(2)T_(x)/g-C_(3)N_(4)humidity sensor.The Ti_(3)C_(2)T_(x)/g-C_(3)N_(4)humidity sensor can monitor skin humidity and high-humidity alarm,which demonstrates great potential applications in various fields.展开更多
Clinical practice has shown that Parkin is the major causative gene found in an autosomal recessive juvenile parkin-sonism(AR-JP)via Parkin mutations and that the Parkin protein is the core expression product of the P...Clinical practice has shown that Parkin is the major causative gene found in an autosomal recessive juvenile parkin-sonism(AR-JP)via Parkin mutations and that the Parkin protein is the core expression product of the Parkin gene,which itself belongs to an E3 ubiquitin ligase.Since the discovery of the Parkin gene in the late 1990s,researchers in many countries have begun extensive research on this gene and found that in addition to AR-JP,the Parkin gene is associated with many diseases,including type 2 diabetes,leprosy,Alzheimer’s,autism,and cancer.Recent studies have found that the loss or dysfunction of Parkin has a certain relationship with tumorigenesis.In general,the Parkin gene,a well-established tumor suppressor,is deficient and mutated in a variety of malignancies.Parkin overexpres-sion inhibits tumor cell growth and promotes apoptosis.However,the functions of Parkin in tumorigenesis and its regulatory mechanisms are still not fully understood.This article describes the structure,functions,and post-transla-tional modifications of Parkin,and summarizes the recent advances in the tumor suppressive function of Parkin and its underlying mechanisms.展开更多
Background and Aims:The concurrence of nonalcoholic steatohepatitis(NASH)and ulcerative colitis(UC)is increasingly seen in clinical practice,but the underlying mechanisms remain unclear.This study aimed to develop a m...Background and Aims:The concurrence of nonalcoholic steatohepatitis(NASH)and ulcerative colitis(UC)is increasingly seen in clinical practice,but the underlying mechanisms remain unclear.This study aimed to develop a mouse model of the phenomenon by combining high-fat high-cholesterol diet(HFHCD)-induced NASH and dextran sulfate sodium(DSS)-induced UC,that would support mechanistic studies.Methods:Male C57BL/6 mice were randomly assigned to two groups receiving either a chow diet or HFHCD for 12 weeks of NASH modeling.The mice were divided into four subgroups for UC modeling:(1)A control group given a chow diet with normal drinking water;(2)A colitis group given chow diet with 2%DSS in drinking water;(3)A steatohepatitis group given HFHCD with normal drinking water;and(4)A steatohepatitis+colitis group given HFHCD with 2%DSS in drinking water.Results:NASH plus UC had high mortality(58.3%).Neither NASH nor UC alone were fatal.Although DSS-induced colitis did not exacerbate histological liver injury in HFHCD-fed mice,premorbid NASH significantly increased UC-related gut injury compared with UC alone.It was characterized by a significantly shorter colon,more colonic congestion,and a higher histopathological score(p<0.05).Inflammatory(tumor necrosis factor-alpha,interleukin 1 beta,C-C motif chemokine ligand 2,and nuclear factor kappa B)and apoptotic(Bcl2,Bad,Bim,and Bax)signaling pathways were significantly altered in distal colon tissues collected from mice with steatohepatitis+colitis compared with the other experimental groups.Conclusions:Premorbid steatohepatitis significantly aggravated DSS-induced colitis and brought about a lethal phenotype.Potential links between NASH and UC pathogeneses can be investigated using this model.展开更多
基金financially supported by the National Natural Science Foundation of China(No.51775353)the National Key Research and Development Program of China(No.2019YFB2006501)+2 种基金the Program for Natural Science Foundation of Liaoning Province(No.2021-BS-150)Science and Technology Program of Liaoning Provincial Department of Education(LJKZ0116)Hebei Key Laboratory of Dielectric and Electrolyte Functional Material,Northeastern University at Qinhuangdao(HKDEFM2021204)。
文摘Temperature has an important impact on the corrosion resistance of mold with cooling channels prepared by casting method.The effect of preheating temperature of the mold and the carbon fiber core on the roughness and corrosion resistance of U-shaped cooling channels made of Al-12Si alloy was examined in depth.The experimental results suggest that as the preheating temperature increased from 273 K to 573 K,the roughness of the inner wall of the cooling channel reduced from 96.6μm to 77.0μm.When the preheating temperature continued to increase to 723 K,the roughness increased to 85.3μm.The wetting between the Al melt and the carbon fiber will reduce micro bubbles and waves on the channel wall as the preheating temperature rises,thereby reducing the roughness.However,with the further increase of preheating temperature,it will increase the solidification time of the Al melt.At this time,the carbon fiber and Al melt will take more time to react,which increases the roughness of the channel wall to a certain extent.The results of exfoliation corrosion show that the larger roughness will aggravate exfoliation corrosion.The prolongation of high temperature reaction time between the carbon fiber and the Al melt will lead to the segregation of Si,which is easy to cause intergranular corrosion.Therefore,reasonable preheating temperature has an important impact on the roughness and corrosion resistance of U-shaped cooling channels.
文摘AIM:To investigate changes in macular vessels and thickness in myopic eyes after intraocular collamer lens(ICL)implantation using quantitative optical coherence tomography angiography(OCTA).METHODS:This retrospective included 73 myopic eyes of 73 patients(average age,27.53±6.16 y)who underwent ICL implantation(28 eyes were Toric ICL).Axial length(AL),uncorrected visual acuity(UCVA),refractive dioptre(RD),intraocular pressure(IOP)and OCTA were measured and compared with before and 1 wk,1,and 3 mo after surgery.OCTA was used to image vessel density(VD)and skeleton density(SD)in both the superficial(SCP)and deep capillary plexus(DCP).Central retinal thickness(CRT)and ganglion cellinner plexiform layer thickness(GCT)were also measured.Changes between pre-and postoperative measurements were analysed by repeated measures analysis of variance.RESULTS:Compared with preoperative data,postoperative data on UCVA revealed significant improvements in all patients(P<0.05).However,there was no significant difference in IOP.After the operation,CRT and GCT exhibited significant changes(P<0.05).Among these measures,CRT was significantly higher at one and three months postoperative(all P<0.01).GCT was significantly higher at 1 wk,1,and 3 mo postoperative(all P<0.01).Changes in VD and SD were nonsignificant in both the SCP and DCP.There was no difference in postoperative changes between the ICL and Toric ICL groups.CONCLUSION:ICL and Toric ICL implantation both have good efficacy and safety for myopic eyes,but macular area changes that occur after surgery need attention.
基金financially supported by the National Natural Science Foundation of China(Nos.51777215 and 52005147)the Special Foundation of Taishan Scholar Project。
文摘This paper reported the impedance-type humidity sensor based on Ti_(3)C_(2)T_(x)/g-C_(3)N_(4)nanomaterials which was fabricated on a flexible polyethylene terephthalate(PET)substrate.The scanning electron microscopy(SEM),X-ray diffraction(XRD),and X-ray photoelectron spectroscopy(XPS)measurements were used to demonstrate the successful synthesis and combination of Ti_(3)C_(2)T_(x)and g-C_(3)N_(4)nanomaterials.The performance of the humidity sensor was tested at room temperature.The experimental results showed that the Ti_(3)C_(2)T_(x)nanosheets with g-C_(3)N_(4)nanosheets endowed the humidity sensor with an ultra-high response,rapid response/recovery time,and negligible hysteresis.The complex impedance spectroscopy(CIS)and bode diagrams were used to further analyze the sensing mechanism of the Ti_(3)C_(2)T_(x)/g-C_(3)N_(4)humidity sensor.The Ti_(3)C_(2)T_(x)/g-C_(3)N_(4)humidity sensor can monitor skin humidity and high-humidity alarm,which demonstrates great potential applications in various fields.
基金Project supported by the National Natural Science Foundation of China(Nos.31270343 and 31500247)the China Postdoctoral Science Foundation(No.2015M581922)
基金This work was supported by the National Natural Science Foundation of China(81622005)Beijing Natural Science Foundation(7172213).
文摘Clinical practice has shown that Parkin is the major causative gene found in an autosomal recessive juvenile parkin-sonism(AR-JP)via Parkin mutations and that the Parkin protein is the core expression product of the Parkin gene,which itself belongs to an E3 ubiquitin ligase.Since the discovery of the Parkin gene in the late 1990s,researchers in many countries have begun extensive research on this gene and found that in addition to AR-JP,the Parkin gene is associated with many diseases,including type 2 diabetes,leprosy,Alzheimer’s,autism,and cancer.Recent studies have found that the loss or dysfunction of Parkin has a certain relationship with tumorigenesis.In general,the Parkin gene,a well-established tumor suppressor,is deficient and mutated in a variety of malignancies.Parkin overexpres-sion inhibits tumor cell growth and promotes apoptosis.However,the functions of Parkin in tumorigenesis and its regulatory mechanisms are still not fully understood.This article describes the structure,functions,and post-transla-tional modifications of Parkin,and summarizes the recent advances in the tumor suppressive function of Parkin and its underlying mechanisms.
基金supported by the National Key Research and Development Program,No.2017YFC0908903National Natural Science Foundation of China,No.81873565,81900507,82170593.
文摘Background and Aims:The concurrence of nonalcoholic steatohepatitis(NASH)and ulcerative colitis(UC)is increasingly seen in clinical practice,but the underlying mechanisms remain unclear.This study aimed to develop a mouse model of the phenomenon by combining high-fat high-cholesterol diet(HFHCD)-induced NASH and dextran sulfate sodium(DSS)-induced UC,that would support mechanistic studies.Methods:Male C57BL/6 mice were randomly assigned to two groups receiving either a chow diet or HFHCD for 12 weeks of NASH modeling.The mice were divided into four subgroups for UC modeling:(1)A control group given a chow diet with normal drinking water;(2)A colitis group given chow diet with 2%DSS in drinking water;(3)A steatohepatitis group given HFHCD with normal drinking water;and(4)A steatohepatitis+colitis group given HFHCD with 2%DSS in drinking water.Results:NASH plus UC had high mortality(58.3%).Neither NASH nor UC alone were fatal.Although DSS-induced colitis did not exacerbate histological liver injury in HFHCD-fed mice,premorbid NASH significantly increased UC-related gut injury compared with UC alone.It was characterized by a significantly shorter colon,more colonic congestion,and a higher histopathological score(p<0.05).Inflammatory(tumor necrosis factor-alpha,interleukin 1 beta,C-C motif chemokine ligand 2,and nuclear factor kappa B)and apoptotic(Bcl2,Bad,Bim,and Bax)signaling pathways were significantly altered in distal colon tissues collected from mice with steatohepatitis+colitis compared with the other experimental groups.Conclusions:Premorbid steatohepatitis significantly aggravated DSS-induced colitis and brought about a lethal phenotype.Potential links between NASH and UC pathogeneses can be investigated using this model.
