Retroperitoneal liposarcoma(RLPS)is the main subtype of retroperitoneal soft sarcoma(RSTS)and has a poor prognosis and few treatment options,except for surgery.The proteomic and metabolic profiles of RLPS have remaine...Retroperitoneal liposarcoma(RLPS)is the main subtype of retroperitoneal soft sarcoma(RSTS)and has a poor prognosis and few treatment options,except for surgery.The proteomic and metabolic profiles of RLPS have remained unclear.The aim of our study was to reveal the metabolic profile of RLPS.Here,we performed proteomic analysis(n=10),metabolomic analysis(n=51),and lipidomic analysis(n=50)of retroperitoneal dedifferentiated liposarcoma(RDDLPS)and retroperitoneal well-differentiated liposarcoma(RWDLPS)tissue and paired adjacent adipose tissue obtained during surgery.Data analysis mainly revealed that glycolysis,purine metabolism,pyrimidine metabolism and phospholipid formation were upregulated in both RDDLPS and RWDLPS tissue compared with the adjacent adipose tissue,whereas the tricarboxylic acid(TCA)cycle,lipid absorption and synthesis,fatty acid degradation and biosynthesis,as well as glycine,serine,and threonine metabolism were downregulated.Of particular importance,the glycolytic inhibitor 2-deoxy-D-glucose and pentose phosphate pathway(PPP)inhibitor RRX-001 significantly promoted the antitumor effects of the MDM2 inhibitor RG7112 and CDK4 inhibitor abemaciclib.Our study not only describes the metabolic profiles of RDDLPS and RWDLPS,but also offers potential therapeutic targets and strategies for RLPS.展开更多
To the Editor:Liposarcoma is a common subtype of retroperitoneal sarcoma.Due to the complicated anatomical heterogeneity of retroperitoneal liposarcoma(RPLS),it compresses and invades adjacent important organs,and mas...To the Editor:Liposarcoma is a common subtype of retroperitoneal sarcoma.Due to the complicated anatomical heterogeneity of retroperitoneal liposarcoma(RPLS),it compresses and invades adjacent important organs,and massive bleeding frequently occurs during surgery.Therefore,a combined visceral resection is required,which means that RPLS surgery has greater difficulty and a lower complete resection rate compared to surgeries for other solid tumors.Although in our previous studies we found that intraperitoneal thermoperfusion chemotherapy including cisplatin may improve the prognosis of patients with RPLS,[1]surgery is the most effective treatment for RPLS,and adjuvant therapies have shown almost ineffective.There is a paucity of research focusing specifically on molecular mechanisms underlying RPLS pathogenesis.Consequently,no diagnostic biomarkers,druggable targets,or prognostic factors are available for RPLS.展开更多
当前工作场合普遍存在着加班时间长、加班无报酬、大小周、“996”乃至“007”工作制等现象,其对员工造成的一系列影响,甚至是引发的“过劳死”等现象备受关注。国内外针对加班内涵及效应的研究取得一定进展,但由于缺乏针对加班的内涵...当前工作场合普遍存在着加班时间长、加班无报酬、大小周、“996”乃至“007”工作制等现象,其对员工造成的一系列影响,甚至是引发的“过劳死”等现象备受关注。国内外针对加班内涵及效应的研究取得一定进展,但由于缺乏针对加班的内涵、测量、结果变量及其作用机制的系统化梳理,导致理论界和实践界均无法形成针对加班现象、效应及其应对的科学认识。本研究通过对中国知网和Web of Science(1995—2021)来源期刊中与加班内涵及效应相关的文献进行检索与筛选,采用“系统性文献综述”这一分析方法,首先对加班相关文献发表趋势、期刊以及研究热点进行描述性分析,而后解构“员工如何科学地认识和应对加班现象”这一核心问题,从加班内涵与测量、加班对员工的影响效应及其作用机制三个方面来进行系统性综述,最终提出从加班的测量维度拓展、加班对员工影响效应的扩展、加班影响员工的作用机制的丰富与整合、跨文化比较与研究设计的探索等方面展开未来研究。展开更多
Rechargeable sodium ion battery(SIB)has attracted much attention recently.However,the deficiency of high-performance electrode materials limits its commercial development.Exploring new cost-effective,high safe electro...Rechargeable sodium ion battery(SIB)has attracted much attention recently.However,the deficiency of high-performance electrode materials limits its commercial development.Exploring new cost-effective,high safe electrode materials and full battery matching technology is an important direction of future research.In this work,a novel watermelon-like multicore-shell Fe(PO_(3))_(2)@C nanocapsule anode material is designed via a facile and eco-friendly process for high performance SIB.Fe(PO_(3))_(2)@C composite anode exhibits remarkable electrochemical performances for SIB,showing high sodium storage capacity(452 mAh·g^(-1) at 0.2 A·g^(-1)),good rate(235 mAh·g^(-1) at 10 A·g^(-1)),stable long-term cycling life(210 mAh·g^(-1) over 2,000 cycles under 5 A·g^(-1)),and superior high-low temperature performance.Furthermore,a new type all iron-based phosphate full battery with high specific capacity is constructed,which can output initial capacity of 309 mAh·g^(-1) and a high energy density of 254,107,and 82 Wh·kg^(-1) at the power density of 186,917,and 1,640 W·kg^(-1) at room temperature.The exceptional performance of multicoreshell Fe(PO_(3))_(2)@C nanocapsule structure can be ascribed to the large specific surface,good structure stability,high conductivity,as well as the multiple layer protection for superior electron/ion transportation.展开更多
基金funded by grants from the National Natural Science Foundation of China(No.82272935 to Wengang Li.,Nos.91957120 and 21974114 to Shuhai Lin.)the Scientific Research Foundation for Advanced Talents,Xiang’an Hospital of Xiamen University(No.PM20180917008 to Wengang Li.)+3 种基金Joint laboratory of School of Medicine,Xiamen University-Shanghai Jiangxia Blood Technology Co.Ltd.(No.XDHT2020010C to Wengang Lin and Ye Shen.)the Fundamental Research Funds for the Central Universities(No.20720210001 to Shuhai Lin.)Major Science and Technology Special Project of Fujian Province(No.2022YZ036012 to Shuhai Lin)Natural Science Foundation of Fujian Province(No.2021J01123522 to Zhigang Zheng).
文摘Retroperitoneal liposarcoma(RLPS)is the main subtype of retroperitoneal soft sarcoma(RSTS)and has a poor prognosis and few treatment options,except for surgery.The proteomic and metabolic profiles of RLPS have remained unclear.The aim of our study was to reveal the metabolic profile of RLPS.Here,we performed proteomic analysis(n=10),metabolomic analysis(n=51),and lipidomic analysis(n=50)of retroperitoneal dedifferentiated liposarcoma(RDDLPS)and retroperitoneal well-differentiated liposarcoma(RWDLPS)tissue and paired adjacent adipose tissue obtained during surgery.Data analysis mainly revealed that glycolysis,purine metabolism,pyrimidine metabolism and phospholipid formation were upregulated in both RDDLPS and RWDLPS tissue compared with the adjacent adipose tissue,whereas the tricarboxylic acid(TCA)cycle,lipid absorption and synthesis,fatty acid degradation and biosynthesis,as well as glycine,serine,and threonine metabolism were downregulated.Of particular importance,the glycolytic inhibitor 2-deoxy-D-glucose and pentose phosphate pathway(PPP)inhibitor RRX-001 significantly promoted the antitumor effects of the MDM2 inhibitor RG7112 and CDK4 inhibitor abemaciclib.Our study not only describes the metabolic profiles of RDDLPS and RWDLPS,but also offers potential therapeutic targets and strategies for RLPS.
基金Peking University International Hospital Research Grant(No.YN2019QN11)Beijing Science and Technology Commission"Applied research on clinical characteristics of the capital city"(No.Z171100001017095)
文摘To the Editor:Liposarcoma is a common subtype of retroperitoneal sarcoma.Due to the complicated anatomical heterogeneity of retroperitoneal liposarcoma(RPLS),it compresses and invades adjacent important organs,and massive bleeding frequently occurs during surgery.Therefore,a combined visceral resection is required,which means that RPLS surgery has greater difficulty and a lower complete resection rate compared to surgeries for other solid tumors.Although in our previous studies we found that intraperitoneal thermoperfusion chemotherapy including cisplatin may improve the prognosis of patients with RPLS,[1]surgery is the most effective treatment for RPLS,and adjuvant therapies have shown almost ineffective.There is a paucity of research focusing specifically on molecular mechanisms underlying RPLS pathogenesis.Consequently,no diagnostic biomarkers,druggable targets,or prognostic factors are available for RPLS.
文摘当前工作场合普遍存在着加班时间长、加班无报酬、大小周、“996”乃至“007”工作制等现象,其对员工造成的一系列影响,甚至是引发的“过劳死”等现象备受关注。国内外针对加班内涵及效应的研究取得一定进展,但由于缺乏针对加班的内涵、测量、结果变量及其作用机制的系统化梳理,导致理论界和实践界均无法形成针对加班现象、效应及其应对的科学认识。本研究通过对中国知网和Web of Science(1995—2021)来源期刊中与加班内涵及效应相关的文献进行检索与筛选,采用“系统性文献综述”这一分析方法,首先对加班相关文献发表趋势、期刊以及研究热点进行描述性分析,而后解构“员工如何科学地认识和应对加班现象”这一核心问题,从加班内涵与测量、加班对员工的影响效应及其作用机制三个方面来进行系统性综述,最终提出从加班的测量维度拓展、加班对员工影响效应的扩展、加班影响员工的作用机制的丰富与整合、跨文化比较与研究设计的探索等方面展开未来研究。
基金supported by the National Natural Science Foundation of China(Nos.51802276 and 52072330)The Scientific and Technological Plan of Guangdong Province,China(No.2019B090905005).
文摘Rechargeable sodium ion battery(SIB)has attracted much attention recently.However,the deficiency of high-performance electrode materials limits its commercial development.Exploring new cost-effective,high safe electrode materials and full battery matching technology is an important direction of future research.In this work,a novel watermelon-like multicore-shell Fe(PO_(3))_(2)@C nanocapsule anode material is designed via a facile and eco-friendly process for high performance SIB.Fe(PO_(3))_(2)@C composite anode exhibits remarkable electrochemical performances for SIB,showing high sodium storage capacity(452 mAh·g^(-1) at 0.2 A·g^(-1)),good rate(235 mAh·g^(-1) at 10 A·g^(-1)),stable long-term cycling life(210 mAh·g^(-1) over 2,000 cycles under 5 A·g^(-1)),and superior high-low temperature performance.Furthermore,a new type all iron-based phosphate full battery with high specific capacity is constructed,which can output initial capacity of 309 mAh·g^(-1) and a high energy density of 254,107,and 82 Wh·kg^(-1) at the power density of 186,917,and 1,640 W·kg^(-1) at room temperature.The exceptional performance of multicoreshell Fe(PO_(3))_(2)@C nanocapsule structure can be ascribed to the large specific surface,good structure stability,high conductivity,as well as the multiple layer protection for superior electron/ion transportation.
