Analyses of oligodontia phenotypes and genetic etiologies

Oligodontia is the congenital absence of six or more teeth and comprises the more severe forms of tooth agenesis.Many genes have been implicated in the etiology of tooth agenesis,which is highly variable in its clinical presentation.The purpose of this study was to identify associations between genetic mutations and clinical features of oligodontia patients.An online systematic search of papers published from January 1992 to June 2021 identified 381 oligodontia cases meeting the eligibility criteria of causative gene mutation,phenotype description,and radiographic records.Additionally,ten families with oligodontia were recruited and their genetic etiologies were determined by whole-exome sequence analyses.We identified a novel mutation in WNT10A(c.99_105dup)and eight previously reported mutations in WNT10A(c.433 G>A;c.682 T>A;c.318 C>G;c.511.C>T;c.321 C>A),EDAR(c.581 C>T),and LRP6(c.1003 C>T,c.2747 G>T).Collectively,20 different causative genes were implicated among those 393 cases with oligodontia.For each causative gene,the mean number of missing teeth per case and the frequency of teeth missing at each position were calculated.Genotype–phenotype correlation analysis indicated that molars agenesis is more likely linked to PAX9 mutations,mandibular first premolar agenesis is least associated with PAX9 mutations.

Uniform zinc deposition on O,N-dual functionalized carbon cloth current collector

The society’s urgent demand for environmentally friendly, safe and low-cost energy storage devices has promoted the research of aqueous zinc-ion batteries. However, the uneven deposition of Zn ions on anodes will lead to the growth of the dendrite and reduce the Coulombic efficiency as well as the lifespan of the devices. Herein, we construct an O,N-dual functionalized carbon cloth current collector via a simple hydrothermal strategy, in which the oxygen-containing functional groups and the N heteroatoms can regulate the transmission and deposition of Zn ions, respectively. The proposed synergistic strategy ensures the uniform distribution of Zn ions on the surface of the Zn anode and inhibits the formation of dendrites. The symmetric cell based on the O,N-dual doped carbon cloth presents superior cycling stability(318 h) with a low voltage hysteresis(11.2 mV) at an areal capacity of 1 m Ah cm^(-2)(20% depth of diacharge). Meanwhile, the appreciably low overpotential(16 m V) and high Columbic efficiency(98.2%)also demonstrate that the O,N-dual functionalized carbon cloth can be worked as a promising host for Zn ions deposition.

一种原位还原策略用于构筑无枝晶锌负极

结合了三维结构和亲锌物种的集流体构筑策略被认为是构建高稳定锌金属负极的有效方法.然而,高昂的成本和复杂的制备工艺阻碍了其实际应用.本文通过在有均匀Cu^(2+)锚定的碳布集流体(ACC-600@Cu^(2+))上沉积锌,合理设计了一种稳定的三维锌金属复合阳极(Zn@ACC-600@Cu^(2+)).在锌成核过程中,Cu^(2+)原位还原为金属Cu,然后随着锌的进一步沉积,碳布表面逐渐形成均匀的亲锌的Cu-Zn合金界面层.密度泛函理论计算和实验观察表明,Cu-Zn合金界面不仅可以作为锌离子的亲锌沉积点,而且可以提高导电率,使电场和锌离子通量均匀化.因此,ACC-600@Cu^(2+)集流体可以实现高的镀锌/剥离可逆性,并在15.8 mV的极化电压下稳定循环410 h以上.作为概念验证,我们组装的Zn@ACC-600@Cu^(2+)‖MnO_(2)全电池具有良好的电池倍率性能,与原始碳布相比,其比容量显著提高至110 mA h g^(-1).本文提出的原位还原策略为三维锌金属复合负极的设计提供了一种简便且低成本的方法,促进了无枝晶和高稳定锌金属电池的发展.

Non-cooperative spacecraft proximity control considering target behavior uncertainty

The significant characteristics of space non-cooperative targets include the uncertainties of dynamic parameters and behaviors.Herein,a hybrid proximity control strategy adapted to the behavior uncertainty of a non-cooperative target is presented.First,the relative motion dynamics between the chaser and target is established in the geocentric inertial coordinate system and transcribed based on the chaser spacecraft body coordinate system.Subsequently,to facilitate proximity control under uncertain conditions,an extended state observer is designed to estimate and compensate for the total uncertainty in the relative motion dynamics.Finally,an event-triggered sliding mode control law is designed to track the target with behavior uncertainty and realize synchronization.Numerical simulations demonstrate the effectiveness of the proposed proximity control strategy for both tumbling and maneuvering targets.

An efficient and versatile biopolishing strategy to construct high performance zinc anode

Conventional strategies for highly reversible Zn anodes usually involve complex and time-consuming production processes of current collectors,expensive and toxic electrolyte additives,or the introduction of inactive materials in protective layer.Here,we develop a fast,facile,and environmentally friendly biopolishing method to prepare dendrite-free Zn anodes,which merely involves the simple immersion of Zn foil in a biocompatible cysteine aqueous solution.The ravine structure formed by sulfhydryl etching for 30 min not only increases the electroactive area of Zn anode but also regulates the distribution of electric field and Zn ions,ensuring the homogeneous deposition and stripping of Zn ions.The biopolished Zn anode can be operated steadily for 2,000 h with a low voltage hysteresis at a current density of 1 mA·cm^(−2).In addition,Zn anodes with a cycle life of 500 h can be built by soaking for only 5 min,proving the high efficiency of the proposed method.This strategy is generalized to substances with sulfhydryl groups for polishing Zn electrodes with improved performance.The cysteine-polished Zn//activated carbon supercapacitor can stably run for 20,000 cycles without obvious capacity attenuation.The proposed strategy shows potential for producing advanced Zn anodes.