Permeable carbon fiber based thermoelectric film with exceptional EMI shielding performance and sensor capabilities

Thermoelectric(TE)technologies offer a promising approach for directly converting skin heat into electricity for wearable electronics.Recognizing p-type Sb2Tes and n-type BizTes as top-performing materials at room temperature,their rigid inorganic structure,with ultralow moisture permeability,poses challenges in warm and humid conditions,fostering bacterial growth and potential skin issues.To address this issue,we developed a cross-linked core-shell structure by electrodepositing Sb_(2)Te_(3)(Bi_(2)Te_(3))onto carbon fiber(CF).This architecture significantly improved the electrical conductivity and the Seebeck coefficient,resulting in a remarkable 300-fold increase in the power factor compared to that of pure CF.The CF/Sb_(2)Te_(3) and CF/Bi2Te films demonstrated optimal power factors of 450 and 121μW·m^(-1)·K^(-2),respectively.Moreover,the fabricated films exhibited outstanding moisture permeability,over 3000 g·m^(-2)·d^(-1),exceptional electromagnetic interference shielding efficiency approaching 93 dB,and versatility as sensors for language assistance and respiratory monitoring.These attributes underline their broad applicability,emphasizing their suitability for human health protection in diverse scenarios.

Melphalan-loaded methoxy poly(ethylene glycol)-poly(D,L-lactide)copolymer nanomicelles in the treatment of multiple myeloma

Multiple myeloma(MM)is the second most common hematological tumor characterized by the proliferation of monoclonal plasma cells.Melphalan(MEL)is commonly used in the treatment of MM and is especially essential for patients undergoing autologous stem cell transplantation(ASCT).Although many drugs for MM have been developed in recent years,chemotherapy followed by ASCT remains the optimal option.Melphalan,the backbone of the conditioning regimen,brings severe toxicities at a high dose.Nanodrug delivery systems enable drugs to be highly effective and have low toxicity.In this study,methoxy poly(ethylene glycol)-poly(D,L-lactide)copolymer(MPEG-PDLLA)was chosen to encapsulate melphalan,and the characteristics,effectiveness,and safety of MEL/MPEG-PDLLA in vitro and in vivo were investigated.MEL/MPEG-PDLLA showed slow release and was easily engulfed by MM cells despite a result of the antitumor assay comparable to that of free melphalan in vitro.The in vivo results showed that MEL/MPEG-PDLLA could significantly alleviate tumor burden and prolong survival time without increasing the toxicity to vital organs.In addition,MEL/MPEG-PDLLA could significantly reduce the damage to the intestinal mucosa caused by melphalan.In conclusion,MEL/MPEG-PDLLA shows improved antitumor activity and has the potential to alleviate pains of MM patients undergoing ASCT.