To the Editor:Plastic bronchitis(PB)is a rare pulmonary disease characterized by the production of branching bronchial casts that fill the airways.It is less common in adults than in children,and occurs after 1%to 4%o...To the Editor:Plastic bronchitis(PB)is a rare pulmonary disease characterized by the production of branching bronchial casts that fill the airways.It is less common in adults than in children,and occurs after 1%to 4%of Fontan surgeries.[1]展开更多
The authors regret that there are two errors in the article Fig.4A and Fig.5C due to the mistake of copying and pasting in the process of assembling figures and negligence in the proofreading.
The poor prognosis of triple negative breast cancer(TNBC)results from a lack of approved targeted therapies coupled with aggressive proliferation and metastasis,which is associated with high recurrence and short overa...The poor prognosis of triple negative breast cancer(TNBC)results from a lack of approved targeted therapies coupled with aggressive proliferation and metastasis,which is associated with high recurrence and short overall survival.Here we developed a strategy by employing tumor-targeted selfassembled nanoparticles to coordinately regulate BACH1(BTB domain and CNC homology 1)and mitochondrial metabolism.The BACH1 inhibitor hemin and mitochondria function inhibitor berberine derivative(BD)were used to prepare nanoparticles(BH NPs)followed by the modification of chondroitin sulfate(CS)on the surface of BH NPs to achieve tumor targeting(CS/BH NPs).CS/BH NPs were found to be able to inhibit tumor migration and invasion by significantly decreasing the amounts of tumor cell metabolites,glycolysis and metastasis-associated proteins,which were related to the inhibition of BACH1 function.Meanwhile,decreased mitochondrial membrane potential,activated caspase 3/9 and increased ROS production demonstrated coordinated regulation of BACH1 and mitochondrial metabolism.In a xenograft mice model of breast cancer,CS/BH NPs significantly inhibited tumor growth and metastasis due to the synergetic effect of hemin and BD without showing obvious toxicities for major organs.In sum,the results of efficacy and safety experiments suggest potential clinical significance of the prepared self-assembled CS/BH nanoparticles for the treatment of TNBC.展开更多
基金supported in part by grants from the Project of the National Natural Science Foundation(No.81925001)the Cultivation Project(No.fkzr2017)of Shanghai Pulmonary Hospital.
文摘To the Editor:Plastic bronchitis(PB)is a rare pulmonary disease characterized by the production of branching bronchial casts that fill the airways.It is less common in adults than in children,and occurs after 1%to 4%of Fontan surgeries.[1]
文摘The authors regret that there are two errors in the article Fig.4A and Fig.5C due to the mistake of copying and pasting in the process of assembling figures and negligence in the proofreading.
基金supported by the National Natural Science Foundation of China(Nos.81973264,82104080 and 81773659)Guangdong Basic and Applied Basic Research Foundation,China(Nos.2020A1515010593,2019A1515011954 and 2021A1515012621)+1 种基金Guangdong Provincial Key Laboratory of Construction Foundation,Sun Yat-sen University(No.2019B030301005,China)the Fundamental Research Funds for the Central Universities,Sun Yat-sen University(No.22qntd4509,China).
文摘The poor prognosis of triple negative breast cancer(TNBC)results from a lack of approved targeted therapies coupled with aggressive proliferation and metastasis,which is associated with high recurrence and short overall survival.Here we developed a strategy by employing tumor-targeted selfassembled nanoparticles to coordinately regulate BACH1(BTB domain and CNC homology 1)and mitochondrial metabolism.The BACH1 inhibitor hemin and mitochondria function inhibitor berberine derivative(BD)were used to prepare nanoparticles(BH NPs)followed by the modification of chondroitin sulfate(CS)on the surface of BH NPs to achieve tumor targeting(CS/BH NPs).CS/BH NPs were found to be able to inhibit tumor migration and invasion by significantly decreasing the amounts of tumor cell metabolites,glycolysis and metastasis-associated proteins,which were related to the inhibition of BACH1 function.Meanwhile,decreased mitochondrial membrane potential,activated caspase 3/9 and increased ROS production demonstrated coordinated regulation of BACH1 and mitochondrial metabolism.In a xenograft mice model of breast cancer,CS/BH NPs significantly inhibited tumor growth and metastasis due to the synergetic effect of hemin and BD without showing obvious toxicities for major organs.In sum,the results of efficacy and safety experiments suggest potential clinical significance of the prepared self-assembled CS/BH nanoparticles for the treatment of TNBC.
