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Early identification of scientific breakthroughs through outlier analysis based on research entities
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作者 Yang Zhao mengting zhang +1 位作者 Xiaoli Chen Zhixiong zhang 《Journal of Data and Information Science》 CSCD 2024年第4期90-109,共20页
Purpose:To address the“anomalies”that occur when scientific breakthroughs emerge,this study focuses on identifying early signs and nascent stages of breakthrough innovations from the perspective of outliers,aiming t... Purpose:To address the“anomalies”that occur when scientific breakthroughs emerge,this study focuses on identifying early signs and nascent stages of breakthrough innovations from the perspective of outliers,aiming to achieve early identification of scientific breakthroughs in papers.Design/methodology/approach:This study utilizes semantic technology to extract research entities from the titles and abstracts of papers to represent each paper’s research content.Outlier detection methods are then employed to measure and analyze the anomalies in breakthrough papers during their early stages.The development and evolution process are traced using literature time tags.Finally,a case study is conducted using the key publications of the 2021 Nobel Prize laureates in Physiology or Medicine.Findings:Through manual analysis of all identified outlier papers,the effectiveness of the proposed method for early identifying potential scientific breakthroughs is verified.Research limitations:The study’s applicability has only been empirically tested in the biomedical field.More data from various fields are needed to validate the robustness and generalizability of the method.Practical implications:This study provides a valuable supplement to current methods for early identification of scientific breakthroughs,effectively supporting technological intelligence decision-making and services.Originality/value:The study introduces a novel approach to early identification of scientific breakthroughs by leveraging outlier analysis of research entities,offering a more sensitive,precise,and fine-grained alternative method compared to traditional citation-based evaluations,which enhances the ability to identify nascent breakthrough innovations. 展开更多
关键词 Scientific breakthroughs Outlier analysis Research entities
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开放式仪器分析教学实验设计——基于LEGO积木的模块化激光诱导荧光检测系统的构建 被引量:2
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作者 潘建章 张梦婷 +3 位作者 张箫扬 廖育城 徐欣然 方群 《大学化学》 CAS 2023年第4期291-299,共9页
基于市售乐高(LEGO)积木和3D打印积木构建的光学模块,发展了适用于本科生仪器分析教学实验的模块化激光诱导荧光(Laserinducedfluorescence,LIF)检测系统。将该系统的构建过程引入本科生仪器分析的实验教学中,指导学生基于不同功能的积... 基于市售乐高(LEGO)积木和3D打印积木构建的光学模块,发展了适用于本科生仪器分析教学实验的模块化激光诱导荧光(Laserinducedfluorescence,LIF)检测系统。将该系统的构建过程引入本科生仪器分析的实验教学中,指导学生基于不同功能的积木块,实现LIF系统的组装和搭建,并应用于对荧光素钠溶液浓度的测定。该系统具有成本低、易构建、操作灵活等特点,模块化的构建形式大大降低了仪器搭建门槛,即使没有前期经验的本科生也可在3 h内搭建完成。将模块化构建思想引入开放式教学环节,可激发学生对仪器分析课程的兴趣和热情,同时有助于加深学生对荧光分析原理和LIF检测系统结构的理解,在系统构建过程中还能锻炼学生的动手能力,提高学生发现问题和和解决问题的能力。 展开更多
关键词 激光诱导荧光检测 模块化设计 乐高积木 3D打印 开放式教学
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Cold Stress-induced Glucosyltransferase CsUGT78A15 is Involved in the Formation of Eugenol Glucoside in Camellia sinensis 被引量:7
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作者 Mingyue Zhao Binbin Cai +12 位作者 Jieyang Jin Na zhang Tingting Jing Jingming Wang Yuting Pan Zixiang Zhou Yifan Zhao Yingying Feng Feng Yu mengting zhang Yating Li Zhonghua Liu Chuankui Song 《Horticultural Plant Journal》 SCIE 2020年第6期439-449,共11页
Eugenol is a natural phenolic compound known for its health-promoting properties and its ability to add a floral scent to tea plants.Plant eugenol glycosides have been identified and shown to make important contributi... Eugenol is a natural phenolic compound known for its health-promoting properties and its ability to add a floral scent to tea plants.Plant eugenol glycosides have been identified and shown to make important contributions to fruit floral quality.However,the details of their biosynthesis and metabolism in tea plants are still unknown.Here,eugenol glucoside was unambiguously identified as a native metabolite in the tea plant,and its biosynthesis was shown to be induced by low temperature treatment.Through the analysis of UGTs induced by low temperature,the glycosyltransferase CsUGT78A15 was identified in tea,and its encoded protein was shown to catalyze the glucosylation of eugenol.Vmax/Km ratios showed that eugenol was the most suitable substrate for CsUGT78A15.Sugar donor preference analysis showed that CsUGT78A15 had a higher selectivity for glucose,followed by galactose and glucuronic acid.The expression of CsUGT78A15was correlatedwith the accumulation of eugenol glucoside in different tissues and genotypes of tea.Down-regulation of CsUGT78A15 led to a decreased eugenol glucoside content under cold stress,indicating that CsUGT78A15 plays an important role in the biosynthesis of eugenol glucoside under cold stress.The identification of eugenol glucoside in the tea plant and the discovery of a cold stress-induced eugenol glucosyltransferase in tea provide the foundation for the improvement of tea flavor under cold stress and the biotechnological production of eugenol glucoside. 展开更多
关键词 Camellia sinensis EUGENOL GLUCOSYLTRANSFERASE Cold stress
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Promoter and coding sequence diversity of CsCCD1 may contribute to the differential accumulation of floralβ-ionone in fresh tea leaves 被引量:3
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作者 Jingming Wang Mingyue Zhao +11 位作者 Ting Gao Yingying Feng Feiquan Wang Yuting Pan Jieyang Jin Tingting Jing Mengqian Lu mengting zhang Danyang Guo Xiaochun Wan Wilfried Schwab Chuankui Song 《Horticultural Plant Journal》 SCIE CAS CSCD 2023年第4期837-847,共11页
The carotenoid-derived volatileβ-ionone makes an important contribution to tea fragrance.Here,we qualitatively and quantitatively analysed 15 carotenoids in tea leaves of 13 cultivars by UHPLC-APCI-MS/MS.The 13 culti... The carotenoid-derived volatileβ-ionone makes an important contribution to tea fragrance.Here,we qualitatively and quantitatively analysed 15 carotenoids in tea leaves of 13 cultivars by UHPLC-APCI-MS/MS.The 13 cultivars were divided into two groups by PCA(Principal Component Analysis)clustering analysis of their carotenoid content,and OPLS-DA(Orthogonal projections to latent structures)indicated that the levels ofβ-carotene(VIP=2.89)and lutein(VIP=2.30)were responsible for much of the variation between the two groups.Interestingly,theβ-carotene toβ-ionone conversion rates in Group 1 were higher than in Group 2,while theβ-carotene content was significantly lower in Group 1 than in Group 2.Theβ-ionone content was significantly higher in Group 1.Pearson Correlation Coefficient calculation between the transcription level of candidate genes(CsCCD1 and CsCCD4)and the accumulation ofβ-ionone indicated that CsCCD1 may involve in the formation ofβ-ionone in 13 cultivars.Prokaryotic expression and in vitro enzyme activity assays showed that‘Chuanhuang 1’had an amino acid mutation in carotenoid cleavage dioxygenases 1(CsCCD1)compared with‘Shuchazao’,resulting in a significantly higherβ-ionone content in‘Chuanhuang 1’.Sequence analysis showed that‘Chuanhuang 1’and‘Huangdan’had different CsCCD1 promoter sequences,leading to significantly higher CsCCD1 expression andβ-ionone accumulation in‘Chuanhuang 1’.These results indicated that the promoter and coding sequence diversity of CsCCD1 might contribute to the differential accumulation ofβ-ionone in different tea cultivars. 展开更多
关键词 Camellia sinensis(L.)Kuntze Carotenoid cleavage dioxygenase Β-CAROTENE Β-IONONE PROMOTER Differential accumulation
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A geraniol synthase regulates plant defense via alternative splicing in tea plants 被引量:3
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作者 Hao Jiang mengting zhang +8 位作者 Feng Yu Xuehui Li Jieyang Jin Youjia Zhou Qiang Wang Tingting Jing Xiaochun Wan Wilfried Schwab Chuankui Song 《Horticulture Research》 SCIE CSCD 2023年第10期136-149,共14页
Geraniol is an important contributor to the pleasant floral scent of tea products and one of the most abundant aroma compounds in tea plants;however,its biosynthesis and physiological function in response to stress in... Geraniol is an important contributor to the pleasant floral scent of tea products and one of the most abundant aroma compounds in tea plants;however,its biosynthesis and physiological function in response to stress in tea plants remain unclear.The proteins encoded by the full-length terpene synthase(CsTPS1)and its alternative splicing isoform(CsTPS1-AS)could catalyze the formation of geraniol when GPP was used as a substrate in vitro,whereas the expression of CsTPS1-AS was only significantly induced by Colletotrichum gloeosporioides and Neopestalotiopsis sp.infection.Silencing of CsTPS1 and CsTPS1-AS resulted in a significant decrease of geraniol content in tea plants.The geraniol content and disease resistance of tea plants were compared when CsTPS1 and CsTPS1-AS were silenced.Down-regulation of the expression of CsTPS1-AS reduced the accumulation of geraniol,and the silenced tea plants exhibited greater susceptibility to pathogen infection than control plants.However,there was no significant difference observed in the geraniol content and pathogen resistance between CsTPS1-silenced plants and control plants in the tea plants infected with two pathogens.Further analysis showed that silencing of CsTPS1-AS led to a decrease in the expression of the defense-related genes PR1 and PR2 and SA pathway-related genes in tea plants,which increased the susceptibility of tea plants to pathogens infections.Both in vitro and in vivo results indicated that CsTPS1 is involved in the regulation of geraniol formation and plant defense via alternative splicing in tea plants.The results of this study provide new insights into geraniol biosynthesis and highlight the role of monoterpene synthases in modulating plant disease resistance via alternative splicing. 展开更多
关键词 SPLICING PLANT SUSCEPTIBILITY
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Volatile compound-mediated plant-plant interactions under stress with the tea plant as a model 被引量:1
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作者 Jieyang Jin Mingyue Zhao +9 位作者 Tingting Jing mengting zhang Mengqian Lu Guomeng Yu Jingming Wang Danyang Guo Yuting Pan Timothy D.Hoffmann Wilfried Schwab Chuankui Song 《Horticulture Research》 SCIE CSCD 2023年第9期281-292,共12页
Plants respond to environmental stimuli via the release of volatile organic compounds(VOCs),and neighboring plants constantly monitor and respond to these VOCs with great sensitivity and discrimination.This sensing ca... Plants respond to environmental stimuli via the release of volatile organic compounds(VOCs),and neighboring plants constantly monitor and respond to these VOCs with great sensitivity and discrimination.This sensing can trigger increased plant fitness and reduce future plant damage through the priming of their own defenses.The defense mechanism in neighboring plants can either be induced by activation of the regulatory or transcriptional machinery,or it can be delayed by the absorption and storage of VOCs for the generation of an appropriate response later.Despite much research,many key questions remain on the role of VOCs in interplant communication and plant fitness.Here we review recent research on the VOCs induced by biotic(i.e.insects and pathogens)and abiotic(i.e.cold,drought,and salt)stresses,and elucidate the biosynthesis of stress-induced VOCs in tea plants.Our focus is on the role of stress-induced VOCs in complex ecological environments.Particularly,the roles of VOCs under abiotic stress are highlighted.Finally,we discuss pertinent questions and future research directions for advancing our understanding of plant interactions via VOCs. 展开更多
关键词 STRESS DROUGHT COMPOUND
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First report of Muyocopron laterale causing a new leaf disease of Camellia sinensis in China 被引量:1
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作者 Hao Jiang mengting zhang +3 位作者 Youjia Zhou Xuehui Li Jiaxun Li Chuankui Song 《Beverage Plant Research》 2022年第1期72-75,共4页
Tea plant(Camellia sinensis)diseases are one of the factors that reduce tea production yield and quality.Herein,a new leaf disease of tea plants was observed in tea plantations.A representative isolate was obtained fr... Tea plant(Camellia sinensis)diseases are one of the factors that reduce tea production yield and quality.Herein,a new leaf disease of tea plants was observed in tea plantations.A representative isolate was obtained from diseased leaf by the traditional fungus separation method.The isolate identified was confirmed as Muyocopron laterale based on morphological and molecular results and phylogenetic tree analysis.Pathogenicity tests were conducted on tea plant seedlings,and which is fulfilling Koch’s postulates.The disease was first identified in C.sinensis leaves caused by M.laterale in China.In the future,the results of this studies will enrich our knowledge and help control tea leaf disease. 展开更多
关键词 SINENSIS analysis CAMELLIA
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你会对谁伸出援助之手:可识别受害者效应
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作者 张梦婷 袁萌 邢淑芬 《心理学进展》 2016年第10期1032-1038,共7页
可识别受害者效应是指受害者的可识别性所造成的人们对受害者帮助行为增加的现象,是近年来亲社会行为研究领域出现的新的研究热点。首先,本文阐述了可识别受害者效应的基本概念;其次,本文详细论述了可识别受害者效应潜在的情境、情绪、... 可识别受害者效应是指受害者的可识别性所造成的人们对受害者帮助行为增加的现象,是近年来亲社会行为研究领域出现的新的研究热点。首先,本文阐述了可识别受害者效应的基本概念;其次,本文详细论述了可识别受害者效应潜在的情境、情绪、认知机制;然后,本文从个体与情境交互作用的视角阐述了可识别受害者效应发生的影响因素;最后,本文对该领域的研究方向进行了小结。 展开更多
关键词 亲社会行为 可识别受害者效应
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Transformer architecture based on mutual attention for image-anomaly detection
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作者 mengting zhang Xiuxia TIAN 《Virtual Reality & Intelligent Hardware》 2023年第1期57-67,共11页
Image-anomaly detection, which is widely used in industrial fields. Previous studies that attempted to address this problem often trained convolutional neural network-based models(e.g., autoencoders and generative adv... Image-anomaly detection, which is widely used in industrial fields. Previous studies that attempted to address this problem often trained convolutional neural network-based models(e.g., autoencoders and generative adversarial networks) to reconstruct covered parts of input images and calculate the difference between the input and reconstructed images. However, convolutional operations are effective at extracting local features, making it difficult to identify larger image anomalies. Method To this end, we propose a transformer architecture based on mutual attention for image-anomaly separation. This architecture can capture long-term dependencies and fuse local and global features to facilitate better image-anomaly detection. Result Our method was extensively evaluated on several benchmarks, and experimental results showed that it improved the detection capability by 3.1% and localization capability by 1.0% compared with state-of-the-art reconstruction-based methods. 展开更多
关键词 Anomaly detection Swin transformer Feature fusion Attentional mechanism Unsupervised learning
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Catalytic upgrading biomass-derived ethanol and acetic acid into C4 chemicals
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作者 Tingting Yan mengting zhang +1 位作者 Runzhi Yuan Weili Dai 《Science China Chemistry》 SCIE EI CAS CSCD 2024年第11期3588-3613,共26页
Synthesis of value-added chemicals from biomass is an essential strategy to mitigate the global dependency on fossil resources and achieve the aim of carbon neutrality. Thereinto, ethanol and acetic acid are crucial b... Synthesis of value-added chemicals from biomass is an essential strategy to mitigate the global dependency on fossil resources and achieve the aim of carbon neutrality. Thereinto, ethanol and acetic acid are crucial biomass-derived platform molecules.Recently, catalytic upgrading ethanol and acetic acid into C4 energy-intensive fuels and chemicals via the elongation of carbon backbone has received widespread attention. The primary focus of this review is to systematically describe the recent breakthrough in the conversion of ethanol or acetic acid to C4 chemicals including 1,3-butadiene, n-butenes, isobutene or n-butanol.Special attentions will be given to heterogeneous catalyst design strategies, reaction parameters on the catalytic performance along with the relevant mechanism investigations, as well as their future challenges and opportunities. The present review will provide the detailed insights into the synthesis of C4 chemicals from biomass-derived ethanol and acetic acid and shed a light on the development of highly efficient catalysts. 展开更多
关键词 ETHANOL acetic acid C4 chemicals catalytic upgrading aldol condensation
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Integrated framework for space-and energy-efficient retrofitting in multifunctional buildings:A synergy of agent-based modeling and performance-based modeling
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作者 Yuchi Shen Xinyi Hu +3 位作者 Xiaotong Wang mengting zhang Lirui Deng Wei Wang 《Building Simulation》 SCIE EI CSCD 2024年第9期1579-1600,共22页
This research investigates retrofitting strategies for multifunctional spaces within educational buildings,employing agent-based and performance-based modeling to support decision-making.An experimental matrix was dev... This research investigates retrofitting strategies for multifunctional spaces within educational buildings,employing agent-based and performance-based modeling to support decision-making.An experimental matrix was developed,reflecting three usage scenarios(reading,exhibition,lecture)across four retrofitting schemes.An agent-based model was developed to delineate intricate human behaviors in space and examined the self-organizing behaviors of 30 agents for each scheme in every scenario,evaluating six metrics on spatial efficiency and visual experience.Calibrated models,derived from real data and processed through DesignBuilder software,evaluated three metrics:energy use,thermal comfort,and visual comfort.The research then incorporated metrics from the agent-based model and performance simulation to develop a method for discussing the decision-making process in retrofit strategies.The findings indicate that the optimal retrofitting solution for multifunctional spaces is heavily influenced by the distribution of usage scenarios.Given the substantial influence of space metrics on selecting the optimal retrofit scheme,the proposed framework effectively facilitates decision-making for building retrofits by providing a holistic evaluation of both spatial and energy criteria. 展开更多
关键词 building retrofit agent-based model human behavior simulation measurement of space performance simulation
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典型黑土区农田土壤线虫群落的纬度分布格局及其驱动机制 被引量:2
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作者 刘萍 刘红文 +4 位作者 张淼 高燕 张梦亭 梁爱珍 张士秀 《生物多样性》 CAS CSCD 北大核心 2022年第12期95-105,共11页
东北黑土区是保障我国粮食安全的重要土壤资源,了解该区域内农田土壤线虫的群落组成及其对环境驱动因子的响应机制,对于研究黑土区农田土壤生态系统的生物多样性分布格局具有重要意义。2018年9月,我们在42°50’-49°08’N的典... 东北黑土区是保障我国粮食安全的重要土壤资源,了解该区域内农田土壤线虫的群落组成及其对环境驱动因子的响应机制,对于研究黑土区农田土壤生态系统的生物多样性分布格局具有重要意义。2018年9月,我们在42°50’-49°08’N的典型黑土区采集了93个农田土壤样品,利用形态学鉴定技术分析了土壤线虫群落的组成与结构。共鉴定出47个线虫属(相对丰度> 1%),其中食细菌线虫中的拟丽突属(Acrobeloides)是典型黑土区农田土壤中的优势属(相对丰度> 5%)。土壤线虫总丰富度和总多度均随纬度增加而显著增加,然而类似的变化趋势只出现在食细菌和杂食/捕食线虫中。土壤有机碳是影响土壤线虫丰富度和多度最为重要的环境因子,其次是月平均温度。典型黑土区农田土壤线虫群落结构以47°N为分界线分为南部和北部两类,主要归因于线虫群落中植物寄生和杂食/捕食线虫的相对多度在南、北特征属中存在差异。土壤pH值和容重分别是影响南部与北部黑土区线虫群落最重要的环境因子。本研究明确了典型黑土区农田土壤线虫群落的纬度分布格局及其与环境因素的关系,可为揭示农业活动干扰下土壤生物对环境因子的响应机制提供基础数据和理论参考。 展开更多
关键词 黑土区 线虫 纬度 驱动机制 土壤有机碳
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Designing specific bacterial 16S primers to sequence and quantitate plant endo-bacteriome 被引量:3
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作者 Liying Chen mengting zhang +6 位作者 Da Liu Hongbo Sun Jianxiang Wu Yan Huo Xiaoying Chen Rongxiang Fang Lili zhang 《Science China(Life Sciences)》 SCIE CAS CSCD 2022年第5期1000-1013,共14页
Plant endophytic bacteria colonize the internal tissues of plants and interact with plants closely.The past two decades have witnessed the increasing application of next-generation 16S r RNA gene sequencing in the inv... Plant endophytic bacteria colonize the internal tissues of plants and interact with plants closely.The past two decades have witnessed the increasing application of next-generation 16S r RNA gene sequencing in the investigation of bacterial communities.However,deciphering plant endo-bacterial communities by this method is difficult because of the co-amplification of massive plant organellar DNAs with bacterial 16S.Here,we designed polymerase chain reaction(PCR) primer sets,including799F/1107R,322F/796R,and 322F-Dr/796Rs(primer pair 322F/796R with a penultimate-base substitution in 322F),that can specifically amplify bacterial 16S from plant total DNAs.We computationally and experimentally evaluated the specificity,coverage,and accuracy of the newly designed primer sets.Both 799F/1107R and 322F-Dr/796Rs produced plant DNA-free 16S amplicon libraries or reduced plant DNA contamination to lower than 5% for the plant materials with extremely-low-abundance bacterial communities.The primer set 322F-A/796R was used through absolute quantitative PCR to quantitate the population size of rice leaf or root endo-bacteriome,which revealed 10^(6)–10^(7) and 10^(9)–10^(10) bacteria per gram fresh weight,respectively.These 16S primer sets and amplification methods enable the simple and inexpensive next-generation sequencing and quantification of plant endo-bacteriome,which will significantly advance studies on the plant-related microbiome. 展开更多
关键词 plant endo-bacteriome plant DNA-free amplification 16S rRNA gene next-generation sequencing absolute quantification
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Heterosis in root microbiota inhibits growth of soil-borne fungal pathogens in hybrid rice 被引量:2
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作者 mengting zhang Yinyue Wang +6 位作者 Yuanyi Hu Huacai Wang Yawen Liu Bingran Zhao Jie zhang Rongxiang Fang Yongsheng Yan 《Journal of Integrative Plant Biology》 SCIE CAS CSCD 2023年第4期1059-1076,共18页
In nature,plants are colonized by various microbes that play essential roles in their growth and health.Heterosis is a natural genetic phenomenon whereby first-generation hybrids exhibit superior phenotypic performanc... In nature,plants are colonized by various microbes that play essential roles in their growth and health.Heterosis is a natural genetic phenomenon whereby first-generation hybrids exhibit superior phenotypic performance relative to their parents.It remains unclear whether this concept can be extended to the“hybridization”of microbiota from two parents in their descendants and what benefits the hybrid microbiota might convey.Here,we investigated the structure and function of the root microbiota from three hybrid rice varieties and their parents through amplicon sequencing analysis of bacterial 16S ribosomal DNA(rDNA)and fungal internal transcribed spacer(ITS)regions.We show that the bacterial and fungal root microbiota of the varieties are distinct from those of their parental lines and exhibit potential heterosis features in diversity and composition.Moreover,the root bacterial microbiota of hybrid variety LYP9 protects rice against soil-borne fungal pathogens.Systematic analysis of the protective capabilities of individual strains from a 30-member bacterial synthetic community derived from LYP9 roots indicated that community members have additive protective roles.Global transcription profiling analyses suggested that LYP9 root bacterial microbiota activate rice reactive oxygen species production and cell wall biogenesis,contributing to heterosis for protection.In addition,we demonstrate that the protection conferred by the LYP9 root microbiota is transferable to neighboring plants,potentially explaining the observed hybrid-mediated superior effects of mixed planting.Our findings suggest that some hybrids exhibit heterosis in their microbiota composition that promotes plant health,highlighting the potential for microbiota heterosis in breeding hybrid crops. 展开更多
关键词 HETEROSIS microbiota‐mediated protection rice root microbiota synthetic community
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Design, Synthesis and Biological Evaluation of Potent and Selective S1PR1 Agonists for the Treatment of Ulcerative Colitis 被引量:1
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作者 Huan He mengting Xie +9 位作者 mengting zhang Haiqin zhang Huan Zhu Yuxian Fang Zihao Shen Rui Wang Zhenjiang Zhao Lili Zhu Xuhong Qian Honglin Li 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2022年第22期2625-2632,共8页
The binding of Sphingosine-1-phosphate(S1P)with the S1PR1-5 plays a fundamental physiological role in a number of processes including vascular development and stabilization,lymphocyte migration and distribution.S1P-S1... The binding of Sphingosine-1-phosphate(S1P)with the S1PR1-5 plays a fundamental physiological role in a number of processes including vascular development and stabilization,lymphocyte migration and distribution.S1P-S1PR1 signal axis established roles in immune cell trafficking thus playing a therapeutic role in multiple sclerosis and inflammatory bowel disease.In this study,a series of oxadiazole derivatives were designed and synthesized as S1PR1 agonists based on rational drug design.Among them,compound 9i was identified as a potent and selective S1PR1 agonist with activities onβ-arrestin recruitment(EC50=0.36 nmol/L)and receptor internalization(EC50=8.09 nmol/L).Meanwhile,compound 9i displayed an oral bioavailability up to 93.6%.Based on its excellent activity to S1PR1 and pharmacokinetic properties,compound 9i effectively alleviated dextran sulfate sodium(DSS)-induced ulcerative colitis in mice at a dose of 0.1 mg/kg. 展开更多
关键词 Ulcerativecolitis S1PR1 INFLAMMATION DRUGDESIGN Structure-activity relationships
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