2,4,6-三甲基苯甲酸与5,5'-二甲基-2,2'-联吡啶构筑的系列镧系超分子配合物的晶体结构、热分解机理和性能

利用2,4,6-三甲基苯甲酸和5,5ʹ-二甲基-2,2ʹ-联吡啶配体在溶剂热的条件下成功合成出系列三元稀土超分子配合物[Ln(2,4,6-TMBA)3(5,5ʹ-DM-2,2ʹ-bipy)]2(Ln=Pr 1,Nd 2,Sm 3,Eu 4,Gd 5,Dy 6),并对其进行了单晶X-射线衍射、元素分析、热重分析等一系列表征。研究结果表明配合物1-5同构,中心离子的配位数为9,配合物通过π–π堆积作用形成一维、二维的超分子结构。配合物6具有不同的结构,中心镝离子的配位数为8,分子间通过π–π堆积作用和C-H…O氢键形成一维、二维的超分子结构。利用TG/FTIR技术研究了配合物的热稳定性和热分解机理,荧光光谱表明配合物4可以发射出Eu^(3+)离子的特征荧光,同时对配合物6的磁性进行了初步探究。

Tailored endothelialization enabled by engineered endothelial cell vesicles accelerates remodeling of small-diameter vascular grafts

Current gold standard for the replacement of small-diameter blood vessel(ID<4 mm)is still to utilize the autologous vessels of patients due to the limitations of small-diameter vascular grafts(SDVG)on weak endothelialization,intimal hyperplasia and low patency.Herein,we create the SDVG with the tailored endothelialization by applying the engineered endothelial cell vesicles to camouflaging vascular grafts for the enhancement of vascular remodeling.The engineered endothelial cell vesicles were modified with azide groups(ECVs-N3)through metabolic glycoengineering to precisely link the vascular graft made of PCL-DBCO via click chemistry,and thus fabricating ECVG(ECVs-N3 modified SDVG),which assists inhibition of platelet adhesion and activation,promotion of ECs adhesion and enhancement of anti-inflammation.Furthermore,In vivo single-cell transcriptome analysis revealed that the proportion of ECs in the cell composition of ECVG surpassed that of PCL,and the tailored endothelialization enabled to convert endothelial cells(ECs)into some specific ECs clusters.One of the specific cluster,Endo_C5 cluster,was only detected in ECVG.Consequently,our study integrates the engineered membrane vesicles of ECVs-N3 from native ECs for tailored endothelialization on SDVG by circumventing the limitations of living cells,and paves a new way to construct the alternative endothelialization in vessel remodeling following injury.

帕金森病中的关键金属元素

随着我国人口日趋老龄化,老年退行性疾病呈高发态势,据估计当今我国帕金森病患者占世界一半左右。因此,帕金森病日益成为危害我国人民生命健康的突出问题之一。当前临床上对帕金森病无有效治愈手段,而且对于帕金森病的发病机制仍无定论。在诸多可能的诱因中,过渡金属元素的内稳态失衡和氧化应激,被认为与帕金森病相关。本文以生物体两种必需的过渡金属元素铁和铜为中心,介绍了与细胞内铁元素和铜元素代谢相关的信号通路和基因蛋白,并阐述了铁元素或铜元素稳态失衡对神经细胞造成损伤的可能机制。最后,介绍了同步辐射技术应用于帕金森病中元素分析和机制的研究进展,并展望了帕金森病中生物无机问题的未来研究方向。