Large-scale software systems,which are the most sophisticated human-designed objects,play more and more important role in our daily life.Consequently effective analysis for large-scale software has become an urgent pr...Large-scale software systems,which are the most sophisticated human-designed objects,play more and more important role in our daily life.Consequently effective analysis for large-scale software has become an urgent problem to be solved with the increasing issues of software security and the continuous expansion of software applications scope.For the characteristics of large scale and complex structure in large-scale software,the traditional software analysis techniques are difficult to be used.With the problem of difficulty in presentation,storage and low efficiency in the process of large-scale software analysis,the visualization analysis framework for large-scale software based on software network,named SoNet,is proposed with the combination of complex network theory and program slicing technique.Constraint logic attributes of the programs will be obtained through source code parsing.Then we will construct a global view by the theory of complex network after extracting software structure and behavior,improving user’s perception of software architecture in a macro perspective.Use case slicing will be realized combined with Redis cluster,and accessibility analysis when given a keyword to be analyzed.We evaluate our prototype implementation on an open source software project named SoundSea in Github,and the results suggest that our approach can realize the analysis for large-scale software.展开更多
This work demonstrates the generation of short pulse duration and high-beam-quality laser pulses using transient stimulated Brillouin scattering at a high repetition rate.Thermal effects and optical breakdown are iden...This work demonstrates the generation of short pulse duration and high-beam-quality laser pulses using transient stimulated Brillouin scattering at a high repetition rate.Thermal effects and optical breakdown are identified as the main factors that restrict energy reflectivity and beam quality under high repetition rates and transient situations.Through experimental analysis,the interaction length and focal point size are determined to be the key parameters in reducing the thermal effect by reducing the absorption of the laser pulse by the medium.The obtained results show that pulses with a duration of 175 ps and beam quality M^(2)of around 1.2 can be achieved with a maximum energy reflectivity of over 40%under an interaction length of 50 mm.Furthermore,at an interaction length of 90 mm,a pulse output with a minimum duration of 115 ps(0.5τQ)is achieved.展开更多
Our study investigated the role of oxygen in mediating the FLASH efect.This efect,which was frst reported in vitro in the 1950s and in vivo in the 1970s,recently gained prominence with a number of publications showing...Our study investigated the role of oxygen in mediating the FLASH efect.This efect,which was frst reported in vitro in the 1950s and in vivo in the 1970s,recently gained prominence with a number of publications showing diferential sparing between normal tissues and tumors.Oxygen depletion(and subsequent induction of transient hypoxia)is the oldest and most prominent hypothesis to explain this efect.To better understand how the oxygen depletion hypothesis and oxygen enhancement ratio(OER)are relevant for interpreting FLASH benefts,an analytical model was proposed to estimate the sparing factor.The model incorporated factors such as OER,oxygen partial pressure(pO_(2)),loco-regional oxygen difusion/metabolism,total dose and dose rate.The sparing factor,was used to quantify the sparing of normal tissue(initially physoxic).The radiosensitivity parameters of two cell types(V79 Chinese hamster cells and T1 human kidney cells)were selected.Furthermore,the transient behavior of OER during fnite time intervals was modeled,for both without and with the presence of oxygen transport using a difusion model.For tissues with an oxygen consumption rate of 20mmHg/s and a distance of 60μm away from blood vessels,the sparing factor demonstrates an increase from 1.03/1.06(V79/T1)at 2.5Gy/s up to 1.28/1.72(V79/T1)at 100Gy/s(total dose:10Gy).For normal tissues of initial pO_(2) between 1.5 and 8mmHg,the beneft from pushing the dose rate above 100Gy/s is found to be marginal.Preliminary animal experiments have been conducted for validation.Overall,our study predicts that the dose rate associated with maximum normal tissue protection is between 50Gy/s and 100Gy/s.Other than the postulation of the hypoxic stem cell niches in normal tissues,we believe that a framework based upon the oxygen depletion hypothesis and OER is not able to efciently interpret diferential responses between normal and tumor tissue under FLASH irradiation.展开更多
文摘Large-scale software systems,which are the most sophisticated human-designed objects,play more and more important role in our daily life.Consequently effective analysis for large-scale software has become an urgent problem to be solved with the increasing issues of software security and the continuous expansion of software applications scope.For the characteristics of large scale and complex structure in large-scale software,the traditional software analysis techniques are difficult to be used.With the problem of difficulty in presentation,storage and low efficiency in the process of large-scale software analysis,the visualization analysis framework for large-scale software based on software network,named SoNet,is proposed with the combination of complex network theory and program slicing technique.Constraint logic attributes of the programs will be obtained through source code parsing.Then we will construct a global view by the theory of complex network after extracting software structure and behavior,improving user’s perception of software architecture in a macro perspective.Use case slicing will be realized combined with Redis cluster,and accessibility analysis when given a keyword to be analyzed.We evaluate our prototype implementation on an open source software project named SoundSea in Github,and the results suggest that our approach can realize the analysis for large-scale software.
基金supported by the National Natural Science Foundation of China(Nos.62075056 and 61927815)the Natural Science Foundation of Tianjin(No.20JCZDJC00430)
文摘This work demonstrates the generation of short pulse duration and high-beam-quality laser pulses using transient stimulated Brillouin scattering at a high repetition rate.Thermal effects and optical breakdown are identified as the main factors that restrict energy reflectivity and beam quality under high repetition rates and transient situations.Through experimental analysis,the interaction length and focal point size are determined to be the key parameters in reducing the thermal effect by reducing the absorption of the laser pulse by the medium.The obtained results show that pulses with a duration of 175 ps and beam quality M^(2)of around 1.2 can be achieved with a maximum energy reflectivity of over 40%under an interaction length of 50 mm.Furthermore,at an interaction length of 90 mm,a pulse output with a minimum duration of 115 ps(0.5τQ)is achieved.
基金National Natural Science Foundation of China (62175183)。
文摘Our study investigated the role of oxygen in mediating the FLASH efect.This efect,which was frst reported in vitro in the 1950s and in vivo in the 1970s,recently gained prominence with a number of publications showing diferential sparing between normal tissues and tumors.Oxygen depletion(and subsequent induction of transient hypoxia)is the oldest and most prominent hypothesis to explain this efect.To better understand how the oxygen depletion hypothesis and oxygen enhancement ratio(OER)are relevant for interpreting FLASH benefts,an analytical model was proposed to estimate the sparing factor.The model incorporated factors such as OER,oxygen partial pressure(pO_(2)),loco-regional oxygen difusion/metabolism,total dose and dose rate.The sparing factor,was used to quantify the sparing of normal tissue(initially physoxic).The radiosensitivity parameters of two cell types(V79 Chinese hamster cells and T1 human kidney cells)were selected.Furthermore,the transient behavior of OER during fnite time intervals was modeled,for both without and with the presence of oxygen transport using a difusion model.For tissues with an oxygen consumption rate of 20mmHg/s and a distance of 60μm away from blood vessels,the sparing factor demonstrates an increase from 1.03/1.06(V79/T1)at 2.5Gy/s up to 1.28/1.72(V79/T1)at 100Gy/s(total dose:10Gy).For normal tissues of initial pO_(2) between 1.5 and 8mmHg,the beneft from pushing the dose rate above 100Gy/s is found to be marginal.Preliminary animal experiments have been conducted for validation.Overall,our study predicts that the dose rate associated with maximum normal tissue protection is between 50Gy/s and 100Gy/s.Other than the postulation of the hypoxic stem cell niches in normal tissues,we believe that a framework based upon the oxygen depletion hypothesis and OER is not able to efciently interpret diferential responses between normal and tumor tissue under FLASH irradiation.