Glycosylation,a key mode of protein modification in living organisms,is critical in regulating various biological functions by influencing protein folding,transportation,and localization.Changes in glycosylation patte...Glycosylation,a key mode of protein modification in living organisms,is critical in regulating various biological functions by influencing protein folding,transportation,and localization.Changes in glycosylation patterns are a significant feature of cancer,are associated with a range of pathological activities in cancer-related processes,and serve as critical biomarkers providing new targets for cancer diagnosis and treatment.Glycoproteins like human epidermal growth factor receptor 2(HER2)for breast cancer,alpha-fetoprotein(AFP)for liver cancer,carcinoembryonic antigen(CEA)for colon cancer,and prostatespecific antigen(PSA)for prostate cancer are all tumor biomarkers approved for clinical use.Here,we introduce the diversity of glycosylation structures and newly discovered glycosylation substrate—glycosylated RNA(glycoRNA).This article focuses primarily on tumor metastasis,immune evasion,metabolic reprogramming,aberrant ferroptosis responses,and cellular senescence to illustrate the role of glycosylation in cancer.Additionally,we summarize the clinical applications of protein glycosylation in cancer diagnostics,treatment,and multidrug resistance.We envision a promising future for the clinical applications of protein glycosylation.展开更多
基金supported in part by grants from the following sources:the National Natural Science Foundation of China(82472882,82302987,82303534,82203233,82202966,82173142)the Natural Science Foundation of Hunan Province(2024JJ4025,2023ZJ1122,Z2023086,2023JJ60469,2023JJ40413,2023JJ30372,2023JJ30375,2022JJ80078,2020JJ5336)+5 种基金Key Research and Development Program of Hunan Province(2022SK2051)Science and Technology Innovation Program of Hunan Province(2023RC3199,2023SK4034,2023RC1073)the Research Project of Health Commission of Hunan Province(R2023040,R2023093,202203034978,202202055318,202109031837,202109032010,20201020)the Changsha Science and Technology Board(kh2201054)Ascend Foundation of National cancer center(NCC201909B06)by Hunan Cancer Hospital Climb Plan(ZX2020001-3,YF2020002,2023NSFC-A001,2023NSFC-A002,2023NSFC-A004).
文摘Glycosylation,a key mode of protein modification in living organisms,is critical in regulating various biological functions by influencing protein folding,transportation,and localization.Changes in glycosylation patterns are a significant feature of cancer,are associated with a range of pathological activities in cancer-related processes,and serve as critical biomarkers providing new targets for cancer diagnosis and treatment.Glycoproteins like human epidermal growth factor receptor 2(HER2)for breast cancer,alpha-fetoprotein(AFP)for liver cancer,carcinoembryonic antigen(CEA)for colon cancer,and prostatespecific antigen(PSA)for prostate cancer are all tumor biomarkers approved for clinical use.Here,we introduce the diversity of glycosylation structures and newly discovered glycosylation substrate—glycosylated RNA(glycoRNA).This article focuses primarily on tumor metastasis,immune evasion,metabolic reprogramming,aberrant ferroptosis responses,and cellular senescence to illustrate the role of glycosylation in cancer.Additionally,we summarize the clinical applications of protein glycosylation in cancer diagnostics,treatment,and multidrug resistance.We envision a promising future for the clinical applications of protein glycosylation.
