Aim:Hepatocellular carcinoma(HCC)is one of the most common cancers in the world.If left untreated,liver cancer has a poor prognosis with more than 90%of patients dying of the disease within 5 years of diagnosis.The ai...Aim:Hepatocellular carcinoma(HCC)is one of the most common cancers in the world.If left untreated,liver cancer has a poor prognosis with more than 90%of patients dying of the disease within 5 years of diagnosis.The aim of this study is to assess the value of combined radiofrequency ablation(RFA),followed by trans-arterial chemoembolization(TACE)in the management of HCC.Methods:Fifty HCC patients with chronic liver disease were categorized into two groups according to the modality of locoregional treatment:25 HCC patients treated with RFA followed by TACE within 5 days and 25 HCC patients treated with TACE only.Results:Complete response was achieved in 100%and 84%of the HCC patients after 1 month from combined RFA-TACE therapy and TACE only respectively.The rate of objective response after 7 months was 84%and 44%in the RFA-TACE and TACE groups respectively.One year disease free survival rate was 56%and 24%in RFA-TACE and TACE groups respectively,and overall survival rate was 88%in the RFA-TACE group and 80%in the TACE only group.Conclusion:Combined RFA-TACE appears to be an effective modality and superior to TACE only for the treatment of HCC.展开更多
文摘Aim:Hepatocellular carcinoma(HCC)is one of the most common cancers in the world.If left untreated,liver cancer has a poor prognosis with more than 90%of patients dying of the disease within 5 years of diagnosis.The aim of this study is to assess the value of combined radiofrequency ablation(RFA),followed by trans-arterial chemoembolization(TACE)in the management of HCC.Methods:Fifty HCC patients with chronic liver disease were categorized into two groups according to the modality of locoregional treatment:25 HCC patients treated with RFA followed by TACE within 5 days and 25 HCC patients treated with TACE only.Results:Complete response was achieved in 100%and 84%of the HCC patients after 1 month from combined RFA-TACE therapy and TACE only respectively.The rate of objective response after 7 months was 84%and 44%in the RFA-TACE and TACE groups respectively.One year disease free survival rate was 56%and 24%in RFA-TACE and TACE groups respectively,and overall survival rate was 88%in the RFA-TACE group and 80%in the TACE only group.Conclusion:Combined RFA-TACE appears to be an effective modality and superior to TACE only for the treatment of HCC.
