Based on the direct method of calculating the periodic wave solution proposed by Nakamura,we give an approximate analytical three-periodic solutions of Korteweg-de Vries(KdV)-type equations by perturbation method for ...Based on the direct method of calculating the periodic wave solution proposed by Nakamura,we give an approximate analytical three-periodic solutions of Korteweg-de Vries(KdV)-type equations by perturbation method for the first time.Limit methods have been used to establish the asymptotic relationships between the three-periodic solution separately and another three solutions,the soliton solution,the one-and the two-periodic solutions.Furthermore,it is found that the asymptotic three-soliton solution presents the same repulsive phenomenon as the asymptotic three-soliton solution during the interaction.展开更多
Greenway is a green linear corridor connecting scenic spots, residential areas, nature reserves, road traffic, etc. Rational greenway route selection can not only attract tourists to increase the income of local villa...Greenway is a green linear corridor connecting scenic spots, residential areas, nature reserves, road traffic, etc. Rational greenway route selection can not only attract tourists to increase the income of local villages, but also arouse people’s awareness of the protection of traditional villages. This paper took Xingtai County, Hebei Province, China as an example to practice greenway route selection in the county territory. Eight factors were selected for greenway route planning, namely elevation, water body, mountain, ecological protection redline, cultural relics protection units, population density, road traffic network, and important transportation hub. These eight factors were assigned in the GIS platform, and the suitability evaluation system of each factor was constructed. The analytic hierarchy process (AHP) and entropy weight method were combined to calculate the weight of these eight factors. The raster calculator was used to weight and overlay the suitability evaluation system of each factor, and the comprehensive suitability evaluation map of greenway route selection was obtained. Based on an important transport hub, along with the water body and the road traffic, the final selection greenway route of traditional villages in Xingtai county was formed. The results of the research can provide a certain reference for the greenway route selection at the county scale.展开更多
A chain of novel higher order rational solutions with some parameters and interaction solutions of a(2+1)-dimensional reverse space–time nonlocal Schrodinger(NLS)equation was derived by a generalized Darboux transfor...A chain of novel higher order rational solutions with some parameters and interaction solutions of a(2+1)-dimensional reverse space–time nonlocal Schrodinger(NLS)equation was derived by a generalized Darboux transformation(DT)which is derived by Taylor expansion and determinants.We obtained a series of higher-order rational solutions by one spectral parameter and we could get the periodic wave solution and three kinds of interaction solutions,singular breather and periodic wave interaction solution,singular breather and traveling wave interaction solution,bimodal breather and periodic wave interaction solution by two spectral parameters.We found a general formula for these solutions in the form of determinants.We also analyzed the complex wave structures of the dynamic behaviors and the effects of special parameters and presented exact solutions for the(2+1)-dimensional reverse space–time nonlocal NLS equation.展开更多
A substantial number of the coal mines in China are in the geological condition of thick alluvium layer. Under these circumstances, it does not make sense to predict ground surface subsidence and other deformations by...A substantial number of the coal mines in China are in the geological condition of thick alluvium layer. Under these circumstances, it does not make sense to predict ground surface subsidence and other deformations by using conventional prediction models. This paper presents a novel ground surface subsidence prediction model for sub-critical mining in the geological condition of thick alluvium layer. The geological composition and mechanical properties of thick alluvium is regarded as a random medium, as are the uniformly distributed loads on rock mass; however, the overburden of the rock mass in the bending zone is looked upon as a hard stratum controlling the ground surface subsidence. The different subsidence and displacement mechanisms for the rock mass and the thick alluvium layer are respectively considered and described in this model, which indicates satisfactory performances in a practical prediction case.展开更多
Adenosine triphosphate(ATP)generation of aquatic organisms is often subject to nanoparticles(NPs)stress,involving extensive reprogramming of gene expression and changes in enzyme activity accompanied by metabolic dist...Adenosine triphosphate(ATP)generation of aquatic organisms is often subject to nanoparticles(NPs)stress,involving extensive reprogramming of gene expression and changes in enzyme activity accompanied by metabolic disturbances.However,little is known about the mechanism of energy supply by ATP to regulate the metabolism of aquatic organisms under NPs stress.Here,we selected extensively existing silver nanoparticles(AgNPs)to investigate their implications on ATP generation and relevant metabolic pathways in alga(Chlorella vulgaris).Results showed that ATP content significantly decreased by 94.2%of the control(without AgNPs)in the algal cells at 0.20 mg/L AgNPs,which was mainly attributed to the reduction of chloroplast ATPase activity(81.4%)and the downregulation of ATPase-coding genes atpB and atpH(74.5%-82.8%)in chloroplast.Molecular dynamics simulations demonstrated that AgNPs competed with the binding sites of substrates adenosine diphosphate and inorganic phosphate by forming a stable complex with ATPase subunit beta,potentially resulting in the reduced binding efficiency of substrates.Furthermore,metabolomics analysis proved that the ATP content positively correlated with the content of most differential metabolites such as D-talose,myo-inositol,and L-allothreonine.AgNPs remarkably inhibited ATPinvolving metabolic pathways,including inositol phosphate metabolism,phosphatidylinositol signaling system,glycerophospholipid metabolism,aminoacyl-tRNA biosynthesis,and glutathione metabolism.These results could provide a deep understanding of energy supply in regulating metabolic disturbances under NPs stress.展开更多
Complete skeletal muscle repair and regeneration due to severe large injury or disease is still a challenge.Biochemical cues are critical to control myoblast cell function and can be utilized to develop smart biomater...Complete skeletal muscle repair and regeneration due to severe large injury or disease is still a challenge.Biochemical cues are critical to control myoblast cell function and can be utilized to develop smart biomaterials for skeletal muscle engineering.Citric acid-based biodegradable polymers have received much attention on tissue engineering,however,their regulation on myoblast cell differentiation and mechanism was few investigated.Here,we find that citrate-based polycitrate-polyethylene glycol-polyethylenimine(POCG-PEI600)nanoclusters can significantly enhance the in vitro myoblast proliferation by probably reinforcing the mitochondrial number,promote the myotube formation and full-thickness skeletal muscle regeneration in vivo by activating the myogenic biomarker genes expression of Myod and Mhc.POCG-PEI600 nanoclusters could also promote the phosphorylation of p38 in MAP kinases(MAPK)signaling pathway,which led to the promotion of the myoblast differentiation.The in vivo skeletal muscle loss rat model also confirmed that POCG-PEI600 nanoclusters could significantly improve the angiogenesis,myofibers formation and complete skeletal muscle regeneration.POCG-PEI600 nanocluster could be also biodegraded into small molecules and eliminated in vivo,suggesting their high biocompatibility and biosafety.This study could provide a bioactive biomaterial-based strategy to repair and regenerate skeletal muscle tissue.展开更多
The efficient cutaneous wound healing accompanied with the enhanced skin appendage regeneration is still a challenge.The bacterial infection and excessive/prolonged inflammation inhibit wound healing process and resul...The efficient cutaneous wound healing accompanied with the enhanced skin appendage regeneration is still a challenge.The bacterial infection and excessive/prolonged inflammation inhibit wound healing process and result in the scar formation.Herein,we reported an anti-inflammatory polycitrate-polyethyleneimine-Ibuprofen(PCEI)and multifunctional PCEI-based F127-ε-polypeptide-alginic(FEA)dressing(FEA-PCEI)for accelerating wound healing and hair follicle neogenesis.PCEI showed the excellent anti-inflammation function through stimulating macrophage towards anti-inflammatory M2 subtype polarization.The FEA-PCEI dressing showed the temperature-response gelation,injectability,robust antibacterial activity,light-damage-resistant,homeostasis ability,and good cytocompatibility.The optimized dosage of FEA-PCEI dressing could significantly accelerate wound healing with anti-infection ability,reduce the scar formation,and promote the hair follicle neogenesis.This study provided a wound-repairing strategy through regulating the phenotype of immune cells by the designing bioactive multifunctional biomaterials.展开更多
基金the National Natural Science Foundation of China(Nos.52174372,51974224)the Natural Science Foundation of Shaanxi Province,China(No.2020JM-047)the Fundamental Research Funds for Central Universities,China(No.xtr0118008)for their support。
基金the National National Science Foundation of China(Grant Nos.52171251,U2106225,and 52231011)the Science and Technology Innovation Fund of Dalian City(Grant No.2022JJ12GX036)。
文摘Based on the direct method of calculating the periodic wave solution proposed by Nakamura,we give an approximate analytical three-periodic solutions of Korteweg-de Vries(KdV)-type equations by perturbation method for the first time.Limit methods have been used to establish the asymptotic relationships between the three-periodic solution separately and another three solutions,the soliton solution,the one-and the two-periodic solutions.Furthermore,it is found that the asymptotic three-soliton solution presents the same repulsive phenomenon as the asymptotic three-soliton solution during the interaction.
文摘Greenway is a green linear corridor connecting scenic spots, residential areas, nature reserves, road traffic, etc. Rational greenway route selection can not only attract tourists to increase the income of local villages, but also arouse people’s awareness of the protection of traditional villages. This paper took Xingtai County, Hebei Province, China as an example to practice greenway route selection in the county territory. Eight factors were selected for greenway route planning, namely elevation, water body, mountain, ecological protection redline, cultural relics protection units, population density, road traffic network, and important transportation hub. These eight factors were assigned in the GIS platform, and the suitability evaluation system of each factor was constructed. The analytic hierarchy process (AHP) and entropy weight method were combined to calculate the weight of these eight factors. The raster calculator was used to weight and overlay the suitability evaluation system of each factor, and the comprehensive suitability evaluation map of greenway route selection was obtained. Based on an important transport hub, along with the water body and the road traffic, the final selection greenway route of traditional villages in Xingtai county was formed. The results of the research can provide a certain reference for the greenway route selection at the county scale.
文摘A chain of novel higher order rational solutions with some parameters and interaction solutions of a(2+1)-dimensional reverse space–time nonlocal Schrodinger(NLS)equation was derived by a generalized Darboux transformation(DT)which is derived by Taylor expansion and determinants.We obtained a series of higher-order rational solutions by one spectral parameter and we could get the periodic wave solution and three kinds of interaction solutions,singular breather and periodic wave interaction solution,singular breather and traveling wave interaction solution,bimodal breather and periodic wave interaction solution by two spectral parameters.We found a general formula for these solutions in the form of determinants.We also analyzed the complex wave structures of the dynamic behaviors and the effects of special parameters and presented exact solutions for the(2+1)-dimensional reverse space–time nonlocal NLS equation.
文摘A substantial number of the coal mines in China are in the geological condition of thick alluvium layer. Under these circumstances, it does not make sense to predict ground surface subsidence and other deformations by using conventional prediction models. This paper presents a novel ground surface subsidence prediction model for sub-critical mining in the geological condition of thick alluvium layer. The geological composition and mechanical properties of thick alluvium is regarded as a random medium, as are the uniformly distributed loads on rock mass; however, the overburden of the rock mass in the bending zone is looked upon as a hard stratum controlling the ground surface subsidence. The different subsidence and displacement mechanisms for the rock mass and the thick alluvium layer are respectively considered and described in this model, which indicates satisfactory performances in a practical prediction case.
基金supported by the National Natural Science Foundation of China(Nos.21577117 and 22076160)the Postgraduate Scientific Research Innovation Project of Hunan Province(No.CX20210521).
文摘Adenosine triphosphate(ATP)generation of aquatic organisms is often subject to nanoparticles(NPs)stress,involving extensive reprogramming of gene expression and changes in enzyme activity accompanied by metabolic disturbances.However,little is known about the mechanism of energy supply by ATP to regulate the metabolism of aquatic organisms under NPs stress.Here,we selected extensively existing silver nanoparticles(AgNPs)to investigate their implications on ATP generation and relevant metabolic pathways in alga(Chlorella vulgaris).Results showed that ATP content significantly decreased by 94.2%of the control(without AgNPs)in the algal cells at 0.20 mg/L AgNPs,which was mainly attributed to the reduction of chloroplast ATPase activity(81.4%)and the downregulation of ATPase-coding genes atpB and atpH(74.5%-82.8%)in chloroplast.Molecular dynamics simulations demonstrated that AgNPs competed with the binding sites of substrates adenosine diphosphate and inorganic phosphate by forming a stable complex with ATPase subunit beta,potentially resulting in the reduced binding efficiency of substrates.Furthermore,metabolomics analysis proved that the ATP content positively correlated with the content of most differential metabolites such as D-talose,myo-inositol,and L-allothreonine.AgNPs remarkably inhibited ATPinvolving metabolic pathways,including inositol phosphate metabolism,phosphatidylinositol signaling system,glycerophospholipid metabolism,aminoacyl-tRNA biosynthesis,and glutathione metabolism.These results could provide a deep understanding of energy supply in regulating metabolic disturbances under NPs stress.
基金supported by National Natural Science Foundation of China(Grant No.51872224)Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research,College of Stomatology,Xi’an Jiaotong University(Grant No.2018LHMKFKT004)+1 种基金Special Guidance Funds for the Construction of World-class Universities(disciplines)and Characteristic Development in Central Universities(grant No.PY3A078)the Fundamental Research Funds for the Central Universities(grant No.xzy022019050)。
文摘Complete skeletal muscle repair and regeneration due to severe large injury or disease is still a challenge.Biochemical cues are critical to control myoblast cell function and can be utilized to develop smart biomaterials for skeletal muscle engineering.Citric acid-based biodegradable polymers have received much attention on tissue engineering,however,their regulation on myoblast cell differentiation and mechanism was few investigated.Here,we find that citrate-based polycitrate-polyethylene glycol-polyethylenimine(POCG-PEI600)nanoclusters can significantly enhance the in vitro myoblast proliferation by probably reinforcing the mitochondrial number,promote the myotube formation and full-thickness skeletal muscle regeneration in vivo by activating the myogenic biomarker genes expression of Myod and Mhc.POCG-PEI600 nanoclusters could also promote the phosphorylation of p38 in MAP kinases(MAPK)signaling pathway,which led to the promotion of the myoblast differentiation.The in vivo skeletal muscle loss rat model also confirmed that POCG-PEI600 nanoclusters could significantly improve the angiogenesis,myofibers formation and complete skeletal muscle regeneration.POCG-PEI600 nanocluster could be also biodegraded into small molecules and eliminated in vivo,suggesting their high biocompatibility and biosafety.This study could provide a bioactive biomaterial-based strategy to repair and regenerate skeletal muscle tissue.
基金supported by National Natural Science Foundation of China(Grant No.51872224)Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research,College of Stomatology,Xi'an Jiaotong University(Grant No.2018LHMKFKT004)+2 种基金Special Guidance Funds for the Construction of World-class Universities(disciplines)and Characteristic Development in Central Universities(grant No.PY3A078)the Fundamental Research Funds for the Central Universities(grant No.xzy022019050)Wenzhou Science&Technology Bureau project(grant No.ZY2019003).
文摘The efficient cutaneous wound healing accompanied with the enhanced skin appendage regeneration is still a challenge.The bacterial infection and excessive/prolonged inflammation inhibit wound healing process and result in the scar formation.Herein,we reported an anti-inflammatory polycitrate-polyethyleneimine-Ibuprofen(PCEI)and multifunctional PCEI-based F127-ε-polypeptide-alginic(FEA)dressing(FEA-PCEI)for accelerating wound healing and hair follicle neogenesis.PCEI showed the excellent anti-inflammation function through stimulating macrophage towards anti-inflammatory M2 subtype polarization.The FEA-PCEI dressing showed the temperature-response gelation,injectability,robust antibacterial activity,light-damage-resistant,homeostasis ability,and good cytocompatibility.The optimized dosage of FEA-PCEI dressing could significantly accelerate wound healing with anti-infection ability,reduce the scar formation,and promote the hair follicle neogenesis.This study provided a wound-repairing strategy through regulating the phenotype of immune cells by the designing bioactive multifunctional biomaterials.
