Cellular thin-shell structures are widely applied in ultralightweight designs due to their high bearing capacity and strength-to-weight ratio.In this paper,a full-scale isogeometric topology optimization(ITO)method ba...Cellular thin-shell structures are widely applied in ultralightweight designs due to their high bearing capacity and strength-to-weight ratio.In this paper,a full-scale isogeometric topology optimization(ITO)method based on Kirchhoff-Love shells for designing cellular tshin-shell structures with excellent damage tolerance ability is proposed.This method utilizes high-order continuous nonuniform rational B-splines(NURBS)as basis functions for Kirchhoff-Love shell elements.The geometric and analysis models of thin shells are unified by isogeometric analysis(IGA)to avoid geometric approximation error and improve computational accuracy.The topological configurations of thin-shell structures are described by constructing the effective density field on the controlmesh.Local volume constraints are imposed in the proximity of each control point to obtain bone-like cellular structures.To facilitate numerical implementation,the p-norm function is used to aggregate local volume constraints into an equivalent global constraint.Several numerical examples are provided to demonstrate the effectiveness of the proposed method.After simulation and comparative analysis,the results indicate that the cellular thin-shell structures optimized by the proposed method exhibit great load-carrying behavior and high damage robustness.展开更多
Background:Rehmanniae Radix Praeparata(RRP,Shu Dihuang in Cinese)is a traditional Chinese herb with multiple pharmacological effects and is commonly used to treat blood deficiency syndrome,such as cancer-related anemi...Background:Rehmanniae Radix Praeparata(RRP,Shu Dihuang in Cinese)is a traditional Chinese herb with multiple pharmacological effects and is commonly used to treat blood deficiency syndrome,such as cancer-related anemia(CRA),alone or in combination with other herbs.However,its main active ingredients and mechanisms of action in treating CRA remain unknown.This study aims to elucidate RRP’s potential mechanism and main active components in treating CRA by using network pharmacology and molecular docking technology system.Methods:The main components of RRP were obtained by the TCMSP database and literature search,and active components and potential targets were obtained by the SwissADME and SwissTargetPridiction databases.CRA targets were collected through GeneCards,DisGeNET,and DrugBank databases.Protein-protein interaction networks of potential targets were constructed via STRING 11.5 and analyzed visually with Cytoscape 3.9.1.The Metascape platform was used for Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis,which were subsequently visualized with Cytoscape 3.9.1 or SangerBox platform.Moreover,Autodock Vina was used for the molecular docking of potential targets and main active ingredients that were visualized with PyMOL software.Results:In this study,31 main active ingredients of PPR were screened,and 155 related targets related to CRA were unearthed.Protein-protein interaction results showed that PPR’s core proteins for CRA intervention correlate to STAT3,SRC,MAPK3,MAPK1,PIK3R1,PIK3CA,and AKT.Multiple signaling pathways were closely related to the treatment of CRA intervened by PPR,including the PI3K-Akt signaling pathway,HIF-1 signaling pathway,JAK-STAT3 signaling pathway,TNF-αsignaling,cytokine signaling pathway and NF-kappB signaling pathway,which are closely involved in the proliferation and differentiation of hematopoietic stem cell and inflammatory response.Molecular docking results showed that these potential targets had good conformation with the core active components of RRP for treating CRA.Conclusion:This study revealed RRP’s main active components and potential molecular mechanisms in treating CRA,providing a reference for subsequent basic research.展开更多
Lightweight thin-walled structures with lattice infill are widely desired in satellite for their high stiffness-to-weight ratio and superior buckling strength resulting fromthe sandwich effect.Such structures can be f...Lightweight thin-walled structures with lattice infill are widely desired in satellite for their high stiffness-to-weight ratio and superior buckling strength resulting fromthe sandwich effect.Such structures can be fabricated bymetallic additive manufacturing technique,such as selective laser melting(SLM).However,the maximum dimensions of actual structures are usually in a sub-meter scale,which results in restrictions on their appliance in aerospace and other fields.In this work,a meter-scale thin-walled structure with lattice infill is designed for the fuel tank supporting component of the satellite by integrating a self-supporting lattice into the thickness optimization of the thin-wall.The designed structure is fabricated by SLM of AlSi10Mg and cold metal transfer welding technique.Quasi-static mechanical tests and vibration tests are both conducted to verify the mechanical strength of the designed large-scale lattice thin-walled structure.The experimental results indicate that themeter-scale thin-walled structure with lattice infill could meet the dimension and lightweight requirements of most spacecrafts.展开更多
Topology Optimization(TO)is a powerful numerical technique to determine the optimal material layout in a design domain,which has accepted considerable developments in recent years.The classic Finite Element Method(FEM...Topology Optimization(TO)is a powerful numerical technique to determine the optimal material layout in a design domain,which has accepted considerable developments in recent years.The classic Finite Element Method(FEM)is applied to compute the unknown structural responses in TO.However,several numerical deficiencies of the FEM significantly influence the effectiveness and efficiency of TO.In order to eliminate the negative influence of the FEM on TO,IsoGeometric Analysis(IGA)has become a promising alternative due to its unique feature that the Computer-Aided Design(CAD)model and Computer-Aided Engineering(CAE)model can be unified into a same mathematical model.In the paper,the main intention is to provide a comprehensive overview for the developments of Isogeometric Topology Optimization(ITO)in methods and applications.Finally,some prospects for the developments of ITO in the future are also presented.展开更多
An energy-storage system comprised of lithium-ion battery modules is considered to be a core component of new energy vehicles,as it provides the main power source for the transmission system.However,manufacturing defe...An energy-storage system comprised of lithium-ion battery modules is considered to be a core component of new energy vehicles,as it provides the main power source for the transmission system.However,manufacturing defects in battery modules lead to variations in performance among the cells used in series or parallel configuration.This variation results in incomplete charge and discharge of batteries and non-uniform temperature distribution,which further lead to reduction of cycle life and battery capacity over time.To solve this problem,this work uses experimental and numerical methods to conduct a comprehensive investigation on the clustering of battery cells with similar performance in order to produce a battery module with improved electrochemical performance.Experiments were first performed by dismantling battery modules for the measurement of performance parameters.The kmeans clustering and support vector clustering(SVC)algorithms were then employed to produce battery modules composed of 12 cells each.Experimental verification of the results obtained from the clustering analysis was performed by measuring the temperature rise in the cells over a certain period,while air cooling was provided.It was found that the SVC-clustered battery module in Category 3 exhibited the best performance,with a maximum observed temperature of 32℃.By contrast,the maximum observed temperatures of the other battery modules were higher,at 40℃for Category 1(manufacturer),36℃for Category 2(manufacturer),and 35℃for Category 4(k-means-clustered battery module).展开更多
BACKGROUND Esophageal atresia(EA)is a life-threatening congenital malformation in newborns,and the traditional repair approaches pose technical challenges and are extremely invasive.Therefore,surgeons have been active...BACKGROUND Esophageal atresia(EA)is a life-threatening congenital malformation in newborns,and the traditional repair approaches pose technical challenges and are extremely invasive.Therefore,surgeons have been actively investigating new minimally invasive techniques to address this issue.Magnetic compression anastomosis has been reported in several studies for its potential in repairing EA.In this paper,the primary repair of EA with magnetic compression anastomosis under thoracoscopy was reported.CASE SUMMARY A full-term male weighing 3500 g was diagnosed with EA gross type C.The magnetic devices used in this procedure consisted of two magnetic rings and several catheters.Tracheoesophageal fistula ligation and two purse strings were performed.The magnetic compression anastomosis was then completed thoracoscopically.After the primary repair,no additional operation was conducted.A patent anastomosis was observed on the 15th day postoperatively,and the magnets were removed on the 23rd day.No leakage existed when the transoral feeding started.CONCLUSION Thoracoscopic magnetic compression anastomosis may be a promising minimally invasive approach for repairing EA.展开更多
Nickel–cobalt tellurides are deemed as promising electrode materials for energy storage devices due to their superior conductivity and theoretical specific capacitance.Here,NiCoTe_(2)was successfully fabricated on ca...Nickel–cobalt tellurides are deemed as promising electrode materials for energy storage devices due to their superior conductivity and theoretical specific capacitance.Here,NiCoTe_(2)was successfully fabricated on carbon cloth by facile electrodeposition and hydrothermal synthesis,which can directly serve as a binderless electrode.The NiCoTe_(2)with interconnected nanosheet arrays on a conductive carbon substrate showed a high specific capacitance(924 F/g at 1 A/g)and robust longterm cycling stability(89.6%retention after 5000 cycles).In addition,the assembled NiCoTe_(2)//activiated carbon hybrid supercapacitor achieved a high energy and power density with a short charging time(42.26 Wh/kg at a power density of 760.96 W/kg).This work provides a novel idea to produce bimetallic nickel–cobalt telluride nanosheet array electrodes for high-performance hybrid supercapacitors.展开更多
CoTe@reduced graphene oxide(CoTe@rGO)electrode materials for supercapacitors were prepared by a one-step hydrothermal method in this paper.Compared with that of pure CoTe,the electrochemical performance of CoTe@rGO wa...CoTe@reduced graphene oxide(CoTe@rGO)electrode materials for supercapacitors were prepared by a one-step hydrothermal method in this paper.Compared with that of pure CoTe,the electrochemical performance of CoTe@rGO was significantly improved.The results showed that the optimal CoTe@rGO electrode material has a remarkably high specific capacitance of 810.6 F/g at a current density of 1 A/g.At 5 A/g,the synthesized material retained 77.2%of its initial capacitance even after 5000 charge/discharge cycles,thereby demonstrating good cycling stability.Moreover,even at a high current density of 20 A/g,the composite electrode retained 79.0%of its specific capacitance at 1 A/g,thus confirming its excellent rate performance.An asymmetric supercapacitor(ASC)with a wider potential window and higher energy density was assembled by using 3 M KOH as the electrolyte,the CoTe@rGO electrode as the positive electrode,and active carbon as the negative electrode.The operating voltage of the supercapacitor could be increased to 1.6 V,and its specific capacitance could reach 112.6 F/g at 1 A/g.The specific capacitance retention rate of the fabricated supercapacitor after 5000 charge/discharge cycles at 5 A/g was 87.1%,which confirms its excellent cycling stability.In addition,the ASC revealed a high energy density of 40.04 W·h/kg at a power density of 799.91 W/kg and a high power density of 4004.93 W/kg at an energy density of 33.43 W·h/kg.These results collectively show that CoTe@rGO materials have broad application prospects.展开更多
基金supported by the National Key R&D Program of China(Grant Number 2020YFB1708300)China National Postdoctoral Program for Innovative Talents(Grant Number BX20220124)+1 种基金China Postdoctoral Science Foundation(Grant Number 2022M710055)the New Cornerstone Science Foundation through the XPLORER PRIZE,the Knowledge Innovation Program of Wuhan-Shuguang,the Young Top-Notch Talent Cultivation Program of Hubei Province and the Taihu Lake Innovation Fund for Future Technology(Grant Number HUST:2023-B-7).
文摘Cellular thin-shell structures are widely applied in ultralightweight designs due to their high bearing capacity and strength-to-weight ratio.In this paper,a full-scale isogeometric topology optimization(ITO)method based on Kirchhoff-Love shells for designing cellular tshin-shell structures with excellent damage tolerance ability is proposed.This method utilizes high-order continuous nonuniform rational B-splines(NURBS)as basis functions for Kirchhoff-Love shell elements.The geometric and analysis models of thin shells are unified by isogeometric analysis(IGA)to avoid geometric approximation error and improve computational accuracy.The topological configurations of thin-shell structures are described by constructing the effective density field on the controlmesh.Local volume constraints are imposed in the proximity of each control point to obtain bone-like cellular structures.To facilitate numerical implementation,the p-norm function is used to aggregate local volume constraints into an equivalent global constraint.Several numerical examples are provided to demonstrate the effectiveness of the proposed method.After simulation and comparative analysis,the results indicate that the cellular thin-shell structures optimized by the proposed method exhibit great load-carrying behavior and high damage robustness.
基金supported by the program for academic promotion program of Shandong First Medical University(No.2019LJ003)the Innovation Team of Shandong Higher School Youth Innovation Technology Program(2022KJ197).
文摘Background:Rehmanniae Radix Praeparata(RRP,Shu Dihuang in Cinese)is a traditional Chinese herb with multiple pharmacological effects and is commonly used to treat blood deficiency syndrome,such as cancer-related anemia(CRA),alone or in combination with other herbs.However,its main active ingredients and mechanisms of action in treating CRA remain unknown.This study aims to elucidate RRP’s potential mechanism and main active components in treating CRA by using network pharmacology and molecular docking technology system.Methods:The main components of RRP were obtained by the TCMSP database and literature search,and active components and potential targets were obtained by the SwissADME and SwissTargetPridiction databases.CRA targets were collected through GeneCards,DisGeNET,and DrugBank databases.Protein-protein interaction networks of potential targets were constructed via STRING 11.5 and analyzed visually with Cytoscape 3.9.1.The Metascape platform was used for Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis,which were subsequently visualized with Cytoscape 3.9.1 or SangerBox platform.Moreover,Autodock Vina was used for the molecular docking of potential targets and main active ingredients that were visualized with PyMOL software.Results:In this study,31 main active ingredients of PPR were screened,and 155 related targets related to CRA were unearthed.Protein-protein interaction results showed that PPR’s core proteins for CRA intervention correlate to STAT3,SRC,MAPK3,MAPK1,PIK3R1,PIK3CA,and AKT.Multiple signaling pathways were closely related to the treatment of CRA intervened by PPR,including the PI3K-Akt signaling pathway,HIF-1 signaling pathway,JAK-STAT3 signaling pathway,TNF-αsignaling,cytokine signaling pathway and NF-kappB signaling pathway,which are closely involved in the proliferation and differentiation of hematopoietic stem cell and inflammatory response.Molecular docking results showed that these potential targets had good conformation with the core active components of RRP for treating CRA.Conclusion:This study revealed RRP’s main active components and potential molecular mechanisms in treating CRA,providing a reference for subsequent basic research.
基金The authors are grateful for the support by National Key Research and Development Program of China(2021YFF0500300,2020YFB1708300)the National Natural Science Foundation of China(52205280,12172041).
文摘Lightweight thin-walled structures with lattice infill are widely desired in satellite for their high stiffness-to-weight ratio and superior buckling strength resulting fromthe sandwich effect.Such structures can be fabricated bymetallic additive manufacturing technique,such as selective laser melting(SLM).However,the maximum dimensions of actual structures are usually in a sub-meter scale,which results in restrictions on their appliance in aerospace and other fields.In this work,a meter-scale thin-walled structure with lattice infill is designed for the fuel tank supporting component of the satellite by integrating a self-supporting lattice into the thickness optimization of the thin-wall.The designed structure is fabricated by SLM of AlSi10Mg and cold metal transfer welding technique.Quasi-static mechanical tests and vibration tests are both conducted to verify the mechanical strength of the designed large-scale lattice thin-walled structure.The experimental results indicate that themeter-scale thin-walled structure with lattice infill could meet the dimension and lightweight requirements of most spacecrafts.
基金Supported by National Key R&D Program of China(Grant No.2020YFB1708304)and Fundamental Research Funds for the Central Universities of the Huazhong University of Science and Technology(Grant No.5003123021)and the Program for HUST Academic Frontier Youth Team(Grant No.2017QYTD04).
文摘Topology Optimization(TO)is a powerful numerical technique to determine the optimal material layout in a design domain,which has accepted considerable developments in recent years.The classic Finite Element Method(FEM)is applied to compute the unknown structural responses in TO.However,several numerical deficiencies of the FEM significantly influence the effectiveness and efficiency of TO.In order to eliminate the negative influence of the FEM on TO,IsoGeometric Analysis(IGA)has become a promising alternative due to its unique feature that the Computer-Aided Design(CAD)model and Computer-Aided Engineering(CAE)model can be unified into a same mathematical model.In the paper,the main intention is to provide a comprehensive overview for the developments of Isogeometric Topology Optimization(ITO)in methods and applications.Finally,some prospects for the developments of ITO in the future are also presented.
基金This work was supported by the National Natural Science Foundation of China(51675196 and 51721092)the program for HUST Academic Frontier Youth Team(2017QYTD04)+2 种基金The authors acknowledge the grant(DMETKF2018019)from the State Key Lab of Digital Manufacturing Equipment and Technology,Huazhong University of Science and Technologythe Sailing Talent Program and the Guangdong University Youth Innovation Talent Project(2016KQNCX053)supported by the Department of Education of Guangdong Provincethe Shantou University Scientific Research Funded Project(NTF16002).
文摘An energy-storage system comprised of lithium-ion battery modules is considered to be a core component of new energy vehicles,as it provides the main power source for the transmission system.However,manufacturing defects in battery modules lead to variations in performance among the cells used in series or parallel configuration.This variation results in incomplete charge and discharge of batteries and non-uniform temperature distribution,which further lead to reduction of cycle life and battery capacity over time.To solve this problem,this work uses experimental and numerical methods to conduct a comprehensive investigation on the clustering of battery cells with similar performance in order to produce a battery module with improved electrochemical performance.Experiments were first performed by dismantling battery modules for the measurement of performance parameters.The kmeans clustering and support vector clustering(SVC)algorithms were then employed to produce battery modules composed of 12 cells each.Experimental verification of the results obtained from the clustering analysis was performed by measuring the temperature rise in the cells over a certain period,while air cooling was provided.It was found that the SVC-clustered battery module in Category 3 exhibited the best performance,with a maximum observed temperature of 32℃.By contrast,the maximum observed temperatures of the other battery modules were higher,at 40℃for Category 1(manufacturer),36℃for Category 2(manufacturer),and 35℃for Category 4(k-means-clustered battery module).
基金the National Key Research and Development Programof China(2020YFB1708300)NationalNatural Science Foundation of China(52075184)+1 种基金Natural Science Foundation of Hubei Province(2019CFA059)Tencent XPLORER PRIZE.
文摘BACKGROUND Esophageal atresia(EA)is a life-threatening congenital malformation in newborns,and the traditional repair approaches pose technical challenges and are extremely invasive.Therefore,surgeons have been actively investigating new minimally invasive techniques to address this issue.Magnetic compression anastomosis has been reported in several studies for its potential in repairing EA.In this paper,the primary repair of EA with magnetic compression anastomosis under thoracoscopy was reported.CASE SUMMARY A full-term male weighing 3500 g was diagnosed with EA gross type C.The magnetic devices used in this procedure consisted of two magnetic rings and several catheters.Tracheoesophageal fistula ligation and two purse strings were performed.The magnetic compression anastomosis was then completed thoracoscopically.After the primary repair,no additional operation was conducted.A patent anastomosis was observed on the 15th day postoperatively,and the magnets were removed on the 23rd day.No leakage existed when the transoral feeding started.CONCLUSION Thoracoscopic magnetic compression anastomosis may be a promising minimally invasive approach for repairing EA.
基金supported by the National Natural Science Foundation of China(No.51877146)。
文摘Nickel–cobalt tellurides are deemed as promising electrode materials for energy storage devices due to their superior conductivity and theoretical specific capacitance.Here,NiCoTe_(2)was successfully fabricated on carbon cloth by facile electrodeposition and hydrothermal synthesis,which can directly serve as a binderless electrode.The NiCoTe_(2)with interconnected nanosheet arrays on a conductive carbon substrate showed a high specific capacitance(924 F/g at 1 A/g)and robust longterm cycling stability(89.6%retention after 5000 cycles).In addition,the assembled NiCoTe_(2)//activiated carbon hybrid supercapacitor achieved a high energy and power density with a short charging time(42.26 Wh/kg at a power density of 760.96 W/kg).This work provides a novel idea to produce bimetallic nickel–cobalt telluride nanosheet array electrodes for high-performance hybrid supercapacitors.
基金supported by the National Natural Science Foundation of China(No.51877146)。
文摘CoTe@reduced graphene oxide(CoTe@rGO)electrode materials for supercapacitors were prepared by a one-step hydrothermal method in this paper.Compared with that of pure CoTe,the electrochemical performance of CoTe@rGO was significantly improved.The results showed that the optimal CoTe@rGO electrode material has a remarkably high specific capacitance of 810.6 F/g at a current density of 1 A/g.At 5 A/g,the synthesized material retained 77.2%of its initial capacitance even after 5000 charge/discharge cycles,thereby demonstrating good cycling stability.Moreover,even at a high current density of 20 A/g,the composite electrode retained 79.0%of its specific capacitance at 1 A/g,thus confirming its excellent rate performance.An asymmetric supercapacitor(ASC)with a wider potential window and higher energy density was assembled by using 3 M KOH as the electrolyte,the CoTe@rGO electrode as the positive electrode,and active carbon as the negative electrode.The operating voltage of the supercapacitor could be increased to 1.6 V,and its specific capacitance could reach 112.6 F/g at 1 A/g.The specific capacitance retention rate of the fabricated supercapacitor after 5000 charge/discharge cycles at 5 A/g was 87.1%,which confirms its excellent cycling stability.In addition,the ASC revealed a high energy density of 40.04 W·h/kg at a power density of 799.91 W/kg and a high power density of 4004.93 W/kg at an energy density of 33.43 W·h/kg.These results collectively show that CoTe@rGO materials have broad application prospects.
