为加强先进绝热压缩空气储能(Advanced Adiabatic Compressed Air Energy Storage,AA-CAES)与综合能源系统(Integrated Energy Systems,IES)的多能互补协同,提高系统运行效率,文中提出了一种含AA-CAES能源站的电-热综合能源系统优化运...为加强先进绝热压缩空气储能(Advanced Adiabatic Compressed Air Energy Storage,AA-CAES)与综合能源系统(Integrated Energy Systems,IES)的多能互补协同,提高系统运行效率,文中提出了一种含AA-CAES能源站的电-热综合能源系统优化运行方法。构建了含AA-CAES能源站的IES基本调度架构,详细分析了AA-CAES装置在压缩和膨胀工况下的储热、换热及供热等特性,建立了AA-CAES电热联供联储运行模型;基于热网管道传热延迟和损耗等动态特性,建立了考虑供热网储热惯性的热网方程;在此基础上,考虑了用户侧可调度资源,提出了计及综合需求响应的含AA-CAES能源站的IES日前优化运行模型;在修改的IEEE 33节点配电网和巴厘岛32节点区域供热网进行算例分析。仿真结果表明,所提方法可有效降低IES运行成本,提高IES可再生能源消纳能力。展开更多
Skeletal stem/progenitor cell(SSPC)senescence is a major cause of decreased bone regenerative potential with aging,but the causes of SSPC senescence remain unclear.In this study,we revealed that macrophages in calluse...Skeletal stem/progenitor cell(SSPC)senescence is a major cause of decreased bone regenerative potential with aging,but the causes of SSPC senescence remain unclear.In this study,we revealed that macrophages in calluses secrete prosenescent factors,including grancalcin(GCA),during aging,which triggers SSPC senescence and impairs fracture healing.Local injection of human rGCA in young mice induced SSPC senescence and delayed fracture repair.Genetic deletion of Gca in monocytes/macrophages was sufficient to rejuvenate fracture repair in aged mice and alleviate SSPC senescence.Mechanistically,GCA binds to the plexin-B2 receptor and activates Arg2-mediated mitochondrial dysfunction,resulting in cellular senescence.Depletion of Plxnb2 in SSPCs impaired fracture healing.Administration of GCA-neutralizing antibody enhanced fracture healing in aged mice.Thus,our study revealed that senescent macrophages within calluses secrete GCA to trigger SSPC secondary senescence,and GCA neutralization represents a promising therapy for nonunion or delayed union in elderly individuals.展开更多
Wireless channel characteristics have significant impacts on channel modeling,estimation,and communication performance.While the channel sparsity is an important characteristic of wireless channels.Utilizing the spars...Wireless channel characteristics have significant impacts on channel modeling,estimation,and communication performance.While the channel sparsity is an important characteristic of wireless channels.Utilizing the sparse nature of wireless channels can reduce the complexity of channel modeling and estimation,and improve system design and performance analysis.Compared with the traditional sub6 GHz channel,millimeter wave(mmWave)channel has been considered to be more sparse in existing researches.However,most research only assume that the mmWave channel is sparse,without providing quantitative analysis and evaluation.Therefore,this paper evaluates the sparsity of mmWave channels based on mmWave channel measurements.A vector network analyzer(VNA)-based mmWave channel sounder is developed to measure the channel at 28 GHz,and multi-scenario channel measurements are conducted.The Gini index,Rician𝐾factor and rootmean-square(RMS)delay spread are used to measure channel sparsity.Then,the key factors affecting mmWave channel sparsity are explored.It is found that antenna steering direction and scattering environment will affect the sparsity of mmWave channel.In addition,the impact of channel sparsity on channel eigenvalue and capacity is evaluated and analyzed.展开更多
In this paper,a massive multiple input multiple output(MIMO)channel measurement campaign with two setups is conducted in an indoor lobby environment.In the first setup,two types of 256-element virtual uniform rectangu...In this paper,a massive multiple input multiple output(MIMO)channel measurement campaign with two setups is conducted in an indoor lobby environment.In the first setup,two types of 256-element virtual uniform rectangular arrays(URAs),i.e.,the 4×64 virtual URA and the 64×4 virtual URA are used.The carrier frequency is 11 GHz;in the second setup,measurements are performed at 4,6,11,13,15,18 GHz at two different user locations.The channel characterization is presented by investigating the typical channel parameters,including average power delay profile(APDP),K factor,root mean square(RMS)delay spread,and coherence bandwidth.Moreover,the channel characteristics in angular domain are investigated by applying the space-alternating generalized expectation-maximization(SAGE)algorithm.The extracted multipath components(MPCs)are preliminarily clustered by visual inspection,and related to the interacting objects(IOs)in physical environment.Multipath structures at multiple frequency bands are examined.Direction spread of departure is estimated to evaluate the directional dispersion at the base station(BS)side.The results in this paper can help to reveal the propagation mechanisms in massive MIMO channels,and provide a foundation for the design and application of the practical massive MIMO system.展开更多
Marine geological disasters occurred frequently in the deep-water slope area of the northern South China Sea,especially submarine landslides,which caused serious damage to marine facilities.The cyclic elastoplastic mo...Marine geological disasters occurred frequently in the deep-water slope area of the northern South China Sea,especially submarine landslides,which caused serious damage to marine facilities.The cyclic elastoplastic model that can describe the cyclic stress-strain response characteristic for soft clay,is embedded into the coupled Eulerian-Lagrangian(CEL)algorithm of ABAQUS by means of subroutine interface technology.On the basis of CEL technique and undrained cyclic elastoplastic model,a method for analyzing the dynamic instability process of marine slopes under the action of earthquake load is developed.The rationality for cyclic elastoplastic constitutive model is validated by comparing its calculated results with those of von Mises model built in Abaqus.The dynamic instability process of slopes under different conditions are analyzed.The results indicate that the deformation accumulation of soft clay have a significant effect on the dynamic instability process of submarine slopes under earthquake loading.The cumulative deformation is taken into our model and this makes the calculated final deformation of the slope under earthquake load larger than the results of conventional numerical method.When different contact conditions are used for analysis,the smaller the friction coefficient is,the larger the deformation of slopes will be.A numerical analysis method that can both reflect the dynamic properties of soft clay and display the dynamic instability process of submarine landslide is proposed,which could visually predict the topographies of the previous and post failure for submarine slope.展开更多
BACKGROUND Congenital muscular dystrophy(CMD)is a clinically and genetically heterogeneous group of inherited muscle disorders.Mutations in the CRPPA gene(encoding CDPLribitol pyrophosphorylase A)are recognized as cau...BACKGROUND Congenital muscular dystrophy(CMD)is a clinically and genetically heterogeneous group of inherited muscle disorders.Mutations in the CRPPA gene(encoding CDPLribitol pyrophosphorylase A)are recognized as causative factors of dystroglycanopathies,a subtype of CMD with defects in glycosylation.CASE SUMMARY The present study examined a Chinese family,whose proband presented mainly with muscle weakness in both lower limbs but without brain and eye symptoms.In this family,a homozygous deletion,c.1114-1116del(p.V372del),was identified in exon 8 of CRPPA in the proband,while a heterozygous deletion was identified in the proband’s father and mother,who lacked symptoms.A mild dystroglycanopathy of CMD was diagnosed.CONCLUSION The findings of this study expanded the clinical and mutational spectrum of patients with CMD associated with CRPPA mutations.展开更多
BACKGROUND Nonketotic hyperglycemia(NKH)is characterized by hyperglycemia with little or no ketoacidosis.Diverse neurological symptoms have been described in NKH patients,including choreoathetosis,hemiballismus,seizur...BACKGROUND Nonketotic hyperglycemia(NKH)is characterized by hyperglycemia with little or no ketoacidosis.Diverse neurological symptoms have been described in NKH patients,including choreoathetosis,hemiballismus,seizures,and coma in severe cases.Homonymous hemianopia,with or without occipital seizures,caused by hyperglycemia is less readily recognized.CASE SUMMARY We describe a 54-year-old man with NKH,who reported seeing round,colored flickering lights with right homonymous hemianopia.Cranial magnetic resonance imaging demonstrated abnormalities in the left occipital lobe,with decreased T2 signal of the white matter,restricted diffusion,and corresponding low signal intensity in the apparent diffusion coefficient map.He responded to rehydration and a low-dose insulin regimen,with improvements of his visual field defect.CONCLUSION Patients with NKH may present focal neurologic signs.Hyperglycemia should be taken into consideration when making an etiologic diagnosis of homonymous hemianopia.展开更多
随着“双碳”目标的提出,多能源交互和新能源消纳的区域综合能源系统(region integrated energy system,RIES)成为研究热点。为兼顾RIES中各主体利益,文中提出一种考虑风光不确定和碳交易的RIES双层博弈优化运行策略。首先,基于多智能...随着“双碳”目标的提出,多能源交互和新能源消纳的区域综合能源系统(region integrated energy system,RIES)成为研究热点。为兼顾RIES中各主体利益,文中提出一种考虑风光不确定和碳交易的RIES双层博弈优化运行策略。首先,基于多智能体技术,建立以能源销售代理商(energy sales agent,ESA)、能源运营代理商(energy operation agent,EOA)和用户代理商(energy use agent,EUA)为主体的双层多智能体系统模型;其次,针对风光出力不确定性,采用蒙特卡洛法进行随机场景生成并通过k-means聚类和同步回代消除技术进行场景削减;然后,在考虑源侧各主体运行收益、碳交易成本以及负荷侧综合需求响应基础上,搭建纵向Stackelberg博弈嵌套横向EOA非合作博弈竞价的双层博弈框架并证明Nash均衡;最后,利用改进双变异差分进化算法结合YALMIP工具箱和商业软件CPLEX在MATLAB中进行仿真分析,算例结果表明所提优化策略可有效实现各主体利益提升的同时减少弃风光率和碳排放量。展开更多
文摘为加强先进绝热压缩空气储能(Advanced Adiabatic Compressed Air Energy Storage,AA-CAES)与综合能源系统(Integrated Energy Systems,IES)的多能互补协同,提高系统运行效率,文中提出了一种含AA-CAES能源站的电-热综合能源系统优化运行方法。构建了含AA-CAES能源站的IES基本调度架构,详细分析了AA-CAES装置在压缩和膨胀工况下的储热、换热及供热等特性,建立了AA-CAES电热联供联储运行模型;基于热网管道传热延迟和损耗等动态特性,建立了考虑供热网储热惯性的热网方程;在此基础上,考虑了用户侧可调度资源,提出了计及综合需求响应的含AA-CAES能源站的IES日前优化运行模型;在修改的IEEE 33节点配电网和巴厘岛32节点区域供热网进行算例分析。仿真结果表明,所提方法可有效降低IES运行成本,提高IES可再生能源消纳能力。
基金This work was supported by the National Key R&D Program of China(Project No.2019YFA0111900 to C.J.L.and Y.J.,2022YFC3601900 to G.H.L.,2022YFC3601903 to X.H.L.,and 2022YFC3601905)the National Natural Science Foundation of China(Grant Nos.82261160397,82272560,81922017 to C.J.L.and 81930022,91749105 to X.H.L.)+3 种基金the NSFC/RGC Joint Research Scheme,the Research Grants Council(UGC)of the Hong Kong Special Administrative Region and the National Natural Science Foundation of China(NSFC/RGC Project No.N_CUHK483/22 to Y.J.)the Hunan Provincial Science and Technology Department(2023JJ30896 to C.J.L.)the Key Research and Development Program of Hunan Province(2022SK2023 to C.J.L.)the Science and Technology Innovation Program of Hunan Province(2023RC1027 to C.J.L.,2022RC1009 to J.W,and 2022RC3075 to C.Z.).
文摘Skeletal stem/progenitor cell(SSPC)senescence is a major cause of decreased bone regenerative potential with aging,but the causes of SSPC senescence remain unclear.In this study,we revealed that macrophages in calluses secrete prosenescent factors,including grancalcin(GCA),during aging,which triggers SSPC senescence and impairs fracture healing.Local injection of human rGCA in young mice induced SSPC senescence and delayed fracture repair.Genetic deletion of Gca in monocytes/macrophages was sufficient to rejuvenate fracture repair in aged mice and alleviate SSPC senescence.Mechanistically,GCA binds to the plexin-B2 receptor and activates Arg2-mediated mitochondrial dysfunction,resulting in cellular senescence.Depletion of Plxnb2 in SSPCs impaired fracture healing.Administration of GCA-neutralizing antibody enhanced fracture healing in aged mice.Thus,our study revealed that senescent macrophages within calluses secrete GCA to trigger SSPC secondary senescence,and GCA neutralization represents a promising therapy for nonunion or delayed union in elderly individuals.
基金supported by National Key R&D Program of China under Grant 2022YFF0608103the National Natural Science Foundation of China under Grant 61922012+1 种基金the Science and Technology Program of State Administration for Market Regulation under Grant 2021MK155the Fundamental Funds of National Institute of Metrology under Grant AKYZD2116-2.
文摘Wireless channel characteristics have significant impacts on channel modeling,estimation,and communication performance.While the channel sparsity is an important characteristic of wireless channels.Utilizing the sparse nature of wireless channels can reduce the complexity of channel modeling and estimation,and improve system design and performance analysis.Compared with the traditional sub6 GHz channel,millimeter wave(mmWave)channel has been considered to be more sparse in existing researches.However,most research only assume that the mmWave channel is sparse,without providing quantitative analysis and evaluation.Therefore,this paper evaluates the sparsity of mmWave channels based on mmWave channel measurements.A vector network analyzer(VNA)-based mmWave channel sounder is developed to measure the channel at 28 GHz,and multi-scenario channel measurements are conducted.The Gini index,Rician𝐾factor and rootmean-square(RMS)delay spread are used to measure channel sparsity.Then,the key factors affecting mmWave channel sparsity are explored.It is found that antenna steering direction and scattering environment will affect the sparsity of mmWave channel.In addition,the impact of channel sparsity on channel eigenvalue and capacity is evaluated and analyzed.
基金supported in part by the National Key Research and Development Program of China under Grant 2016YFE0200900 and 2018YFF0212103in part by NSFC under Grant 61725101, 61771037, 6181101396, and U1834210+4 种基金in part by the Beijing Natural Science Foundation under Grant 4182047 and L172020in part by the Fundamental research funds for the central universities under Grant 2017RC031 and Grant 2018JBM301in part by the Major projects of Beijing Municipal Science and Technology Commission under Grant Z181100003218010in part by the State Key Lab of Rail Traffic Control and Safety under Grant 2017JBM332, RCS2018ZZ007, and Grant RCS2018ZT014in part by the Teaching Reform Project under Grant 134496522
文摘In this paper,a massive multiple input multiple output(MIMO)channel measurement campaign with two setups is conducted in an indoor lobby environment.In the first setup,two types of 256-element virtual uniform rectangular arrays(URAs),i.e.,the 4×64 virtual URA and the 64×4 virtual URA are used.The carrier frequency is 11 GHz;in the second setup,measurements are performed at 4,6,11,13,15,18 GHz at two different user locations.The channel characterization is presented by investigating the typical channel parameters,including average power delay profile(APDP),K factor,root mean square(RMS)delay spread,and coherence bandwidth.Moreover,the channel characteristics in angular domain are investigated by applying the space-alternating generalized expectation-maximization(SAGE)algorithm.The extracted multipath components(MPCs)are preliminarily clustered by visual inspection,and related to the interacting objects(IOs)in physical environment.Multipath structures at multiple frequency bands are examined.Direction spread of departure is estimated to evaluate the directional dispersion at the base station(BS)side.The results in this paper can help to reveal the propagation mechanisms in massive MIMO channels,and provide a foundation for the design and application of the practical massive MIMO system.
基金This work was supported by the National Natural Science Foundation of China(NSFC)(No.51179174).
文摘Marine geological disasters occurred frequently in the deep-water slope area of the northern South China Sea,especially submarine landslides,which caused serious damage to marine facilities.The cyclic elastoplastic model that can describe the cyclic stress-strain response characteristic for soft clay,is embedded into the coupled Eulerian-Lagrangian(CEL)algorithm of ABAQUS by means of subroutine interface technology.On the basis of CEL technique and undrained cyclic elastoplastic model,a method for analyzing the dynamic instability process of marine slopes under the action of earthquake load is developed.The rationality for cyclic elastoplastic constitutive model is validated by comparing its calculated results with those of von Mises model built in Abaqus.The dynamic instability process of slopes under different conditions are analyzed.The results indicate that the deformation accumulation of soft clay have a significant effect on the dynamic instability process of submarine slopes under earthquake loading.The cumulative deformation is taken into our model and this makes the calculated final deformation of the slope under earthquake load larger than the results of conventional numerical method.When different contact conditions are used for analysis,the smaller the friction coefficient is,the larger the deformation of slopes will be.A numerical analysis method that can both reflect the dynamic properties of soft clay and display the dynamic instability process of submarine landslide is proposed,which could visually predict the topographies of the previous and post failure for submarine slope.
基金the Medical and Health Science and Technology Program of Zhejiang Province,No.2018273034.
文摘BACKGROUND Congenital muscular dystrophy(CMD)is a clinically and genetically heterogeneous group of inherited muscle disorders.Mutations in the CRPPA gene(encoding CDPLribitol pyrophosphorylase A)are recognized as causative factors of dystroglycanopathies,a subtype of CMD with defects in glycosylation.CASE SUMMARY The present study examined a Chinese family,whose proband presented mainly with muscle weakness in both lower limbs but without brain and eye symptoms.In this family,a homozygous deletion,c.1114-1116del(p.V372del),was identified in exon 8 of CRPPA in the proband,while a heterozygous deletion was identified in the proband’s father and mother,who lacked symptoms.A mild dystroglycanopathy of CMD was diagnosed.CONCLUSION The findings of this study expanded the clinical and mutational spectrum of patients with CMD associated with CRPPA mutations.
基金The fund of Department of Education Zhejiang Province Scientific Research Project,No.Y201839721Zhejiang Province Medical Science and Technology Project,No.2017174708,No.2020RC061,and No.2018273034+2 种基金the Zhejiang Provincial Natural Scientific Foundation of China,No.LGF20H090011 and No.LY18H090002Zhejiang public welfare Technology Application Research Project,No.LGF20H090011the Medical and Health Science and Technology Program of Zhejiang Province,No.2018273034.
文摘BACKGROUND Nonketotic hyperglycemia(NKH)is characterized by hyperglycemia with little or no ketoacidosis.Diverse neurological symptoms have been described in NKH patients,including choreoathetosis,hemiballismus,seizures,and coma in severe cases.Homonymous hemianopia,with or without occipital seizures,caused by hyperglycemia is less readily recognized.CASE SUMMARY We describe a 54-year-old man with NKH,who reported seeing round,colored flickering lights with right homonymous hemianopia.Cranial magnetic resonance imaging demonstrated abnormalities in the left occipital lobe,with decreased T2 signal of the white matter,restricted diffusion,and corresponding low signal intensity in the apparent diffusion coefficient map.He responded to rehydration and a low-dose insulin regimen,with improvements of his visual field defect.CONCLUSION Patients with NKH may present focal neurologic signs.Hyperglycemia should be taken into consideration when making an etiologic diagnosis of homonymous hemianopia.
文摘随着“双碳”目标的提出,多能源交互和新能源消纳的区域综合能源系统(region integrated energy system,RIES)成为研究热点。为兼顾RIES中各主体利益,文中提出一种考虑风光不确定和碳交易的RIES双层博弈优化运行策略。首先,基于多智能体技术,建立以能源销售代理商(energy sales agent,ESA)、能源运营代理商(energy operation agent,EOA)和用户代理商(energy use agent,EUA)为主体的双层多智能体系统模型;其次,针对风光出力不确定性,采用蒙特卡洛法进行随机场景生成并通过k-means聚类和同步回代消除技术进行场景削减;然后,在考虑源侧各主体运行收益、碳交易成本以及负荷侧综合需求响应基础上,搭建纵向Stackelberg博弈嵌套横向EOA非合作博弈竞价的双层博弈框架并证明Nash均衡;最后,利用改进双变异差分进化算法结合YALMIP工具箱和商业软件CPLEX在MATLAB中进行仿真分析,算例结果表明所提优化策略可有效实现各主体利益提升的同时减少弃风光率和碳排放量。
