Background:In late March 2020,a“Stay Home,Stay Healthy”order was issued in Washington State in response to the COVID-19 pandemic.On May 1,a 4-phase reopening plan began.We investigated whether adjunctive prevention ...Background:In late March 2020,a“Stay Home,Stay Healthy”order was issued in Washington State in response to the COVID-19 pandemic.On May 1,a 4-phase reopening plan began.We investigated whether adjunctive prevention strategies would allow less restrictive physical distancing to avoid second epidemic waves and secure safe school reopening.Methods:We developed a mathematical model,stratifying the population by age,infection status and treatment status to project SARS-CoV-2 transmission during and after the reopening period.The model was parameterized with demographic and contact data from King County,WA and calibrated to confirmed cases,deaths and epidemic peak timing.Adjunctive prevention interventions were simulated assuming different levels of pre-COVID physical interactions(pC_PI)restored.Results:The best model fit estimated~35%pC_PI under the lockdown which prevented~17,000 deaths by May 15.Gradually restoring 75%pC_PI for all age groups between May 15-July 15 would have resulted in~350 daily deaths by early September 2020.Maintaining<45%pC_PI was required with current testing practices to ensure low levels of daily infections and deaths.Increased testing,isolation of symptomatic infections,and contact tracing permitted 60%pC_PI without significant increases in daily deaths before November and allowed opening of schools with<15 daily deaths.Inpatient antiviral treatment was predicted to reduce deaths significantly without lowering cases or hospitalizations.Conclusions:We predict that widespread testing,contact tracing and case isolation would allow relaxation of physical distancing,as well as opening of schools,without a surge in local cases and deaths.展开更多
基金This work was partially supported by National Institutes of Health(5R01AI121129-05)Centers for Disease Control and Prevention(NU38OT000297-02)Washington Research Foundation.
文摘Background:In late March 2020,a“Stay Home,Stay Healthy”order was issued in Washington State in response to the COVID-19 pandemic.On May 1,a 4-phase reopening plan began.We investigated whether adjunctive prevention strategies would allow less restrictive physical distancing to avoid second epidemic waves and secure safe school reopening.Methods:We developed a mathematical model,stratifying the population by age,infection status and treatment status to project SARS-CoV-2 transmission during and after the reopening period.The model was parameterized with demographic and contact data from King County,WA and calibrated to confirmed cases,deaths and epidemic peak timing.Adjunctive prevention interventions were simulated assuming different levels of pre-COVID physical interactions(pC_PI)restored.Results:The best model fit estimated~35%pC_PI under the lockdown which prevented~17,000 deaths by May 15.Gradually restoring 75%pC_PI for all age groups between May 15-July 15 would have resulted in~350 daily deaths by early September 2020.Maintaining<45%pC_PI was required with current testing practices to ensure low levels of daily infections and deaths.Increased testing,isolation of symptomatic infections,and contact tracing permitted 60%pC_PI without significant increases in daily deaths before November and allowed opening of schools with<15 daily deaths.Inpatient antiviral treatment was predicted to reduce deaths significantly without lowering cases or hospitalizations.Conclusions:We predict that widespread testing,contact tracing and case isolation would allow relaxation of physical distancing,as well as opening of schools,without a surge in local cases and deaths.
