背景乙型肝炎病毒(hepatitis B virus,HBV)相关慢性肝病患者外周血T细胞及细胞因子水平与患者免疫功能状态密切相关,不同疾病程度的HBV相关肝病患者的T细胞、细胞因子水平及与肝病阶段的相关性值得进一步探究.目的探究不同阶段HBV相关...背景乙型肝炎病毒(hepatitis B virus,HBV)相关慢性肝病患者外周血T细胞及细胞因子水平与患者免疫功能状态密切相关,不同疾病程度的HBV相关肝病患者的T细胞、细胞因子水平及与肝病阶段的相关性值得进一步探究.目的探究不同阶段HBV相关慢性肝病患者外周血T细胞亚群计数、细胞因子变化特点及关联性.方法本研究为一项观察性研究,共纳入慢性乙型肝炎(chronic hepatitis B,CHB)患者65例,肝硬化失代偿期(decompensated cirrhosis,DCC)患者122例,肝细胞癌(hepatocellular carcinoma,HCC)患者109例,收集患者一般信息、病史、治疗情况及实验室检查结果、Child-Paugh分级及HCC患者肿瘤巴塞罗那分期,分析各项指标,尤其是T细胞亚群计数及细胞因子的组间差异及特征.结果HBV相关肝硬化、HCC患者外周血CD8^(+)T细胞水平与Child分级A到C呈负相关.HCC患者CD8^(+)T细胞绝对计数显著低于DCC[240(150-379)cells/μLvs 277(154-435)cells/μL,P<0.05]及CHB[240(150-379)cells/μL vs 452(269-706)cells/μL,P<0.001]患者.白细胞介素(interleukin,IL)-6、IL-8、肿瘤坏死因子(tumor necrosis factor,TNF)-α在HCC组均最高.DCC、HCC患者Child-Paugh分级越差,CD3^(+)、CD8^(+)T细胞水平越低,IL-6水平越高.HCC患者CD3^(+)、CD8^(+)T细胞水平随着肿瘤巴塞罗那分期由A到D呈下降趋势,IL-6呈上升趋势.且肝硬化、HCC患者CD3^(+)(r=-0.340,P<0.001)、CD8^(+)(r=-0.353,P<0.001)T细胞水平与IL-6升高水平呈显著负相关.结论HBV相关肝硬化、HCC患者外周血CD8^(+)T细胞计数与Child分级(由A到C)呈负相关,且IL-6水平与CD8^(+)T细胞计数存在负相关关系.展开更多
Increased renewable energy integration and international power trades have led to the construction and development of new HVDC transmission systems.HVDC cables,in particular,play an important role in undersea power tr...Increased renewable energy integration and international power trades have led to the construction and development of new HVDC transmission systems.HVDC cables,in particular,play an important role in undersea power transmission and offshore renewable energy integration having lower losses and higher reliability.In this paper,the current commercial feasibility of HVDC cables and the development of different types of HVDC cables and accessories are reviewed.The non-uniform electric field distribution caused by the applied voltage,temperature dependent conductivity,and space charge accumulation is briefly discussed.Current research in HVDC cable for higher operation voltage level and larger power capacity is also reviewed with specific focus on the methodologies of space charge suppression for XLPE extruded cables.展开更多
基金supported by the State Grid Corporation of China:Research on Key Technologies of Insulation Material and Accessories for 320 kV HVDC XLPE Cable System(SGRIZLJS(2014)888).
文摘Increased renewable energy integration and international power trades have led to the construction and development of new HVDC transmission systems.HVDC cables,in particular,play an important role in undersea power transmission and offshore renewable energy integration having lower losses and higher reliability.In this paper,the current commercial feasibility of HVDC cables and the development of different types of HVDC cables and accessories are reviewed.The non-uniform electric field distribution caused by the applied voltage,temperature dependent conductivity,and space charge accumulation is briefly discussed.Current research in HVDC cable for higher operation voltage level and larger power capacity is also reviewed with specific focus on the methodologies of space charge suppression for XLPE extruded cables.
