Pharmacological mechanism of Liuwei Dihuang Decoction in treating Osteoporosis and Alzheimer’s disease based on Network Pharmacology

Objective:To predict the active components,targets of Liuwei Dihuang Decoction for the treatment of osteoporosis and Alzheimer’s disease with network pharmacology analysis.Methods:The components and targets of all the herbs of Liuwei Dihuang Decoction were obtained from ETCM database,Osteoporosis and Alzheimer’s disease targets were extracted from the GeneCards and DrugBank databases,selected based on STRING database for PPI network construction and build the network through the software of Cytoscape,Kyoto Encyclopedia of Genes and Genomes and Gene Ontology analyses were carried out by R software.Results:181 active compounds and 762 disease-related from Liuwei Dihuang Decoction,there were 144 disease-related common targets obtained from Venn Diagram.IL6,TNF,PPARA,PPARG,SRC and other 11 targets are the node protein of the whole network.In the multisystem biological reaction process such as neurotransmitter,glucose and lipid metabolism,calcium and phosphorus metabolism.Conclusion:Liuwei Dihuang pill may play a co-therapeutic role in Osteoporosis and Alzheimer’s disease by participating in the multi-system biological reaction process such as neurotransmitter,glucose and lipid metabolism,calcium and phosphorus metabolism.

Antiviral Properties of Traditional Chinese Medicine against Coronavirus: Research Clues for Coronavirus Disease-2019

The objective of this study was to provide research clues for the prevention and treatment of coronavirus disease-2019(COVID-19)and coronavirus(Co V)infection using Traditional Chinese Medicine(TCM).A review on research and clinical trials that using TCM extracts and active ingredients against Co V was performed,and a table of TCM agents and their effects on Co V were summarized.Relevant analysis was performed and visual expression of the data included summarizing the types of TCM and treatment methods for COVID-19.TCM fighting against Co V is mainly used in the lung and heart channels,and its medicinal properties are mainly cold and mild,while its taste is mainly bitter and sweet.The majority of research focused on treatments that clear away heat and toxic materials and those that strengthen body resistance and tonify deficiencies.TCM has unique advantages to fight against Co V.The development of new anti-Co V therapy using TCM is of great significance for the prevention and treatment of COVID-19 pneumonia and various viral infectious diseases.