Research Progress in Traditional Chinese Medicine Treatment of Knee Osteoarthritis

Knee osteoarthritis(KOA)is a degenerative disease characterized by pathological changes in the cartilage and subchondral bone of the knee joint.Initially,knee joint pain is the main symptom,and in the later stages,deformities and mobility disorders may occur.Modern medicine lacks effective treatment methods for early and mid stage KOA,and has drawbacks such as significant side effects and high costs.A large number of stud‐ies have confirmed that traditional Chinese medicine has unique advantages in treating KOA,and has obvious advantages such as small trauma,low cost,and definite therapeu‐tic effect,which are gradually being accepted by a large number of KOA patients.The commonly used methods for preventing and treating KOA with traditional Chinese medicine in clinical practice include:oral administration of traditional Chinese medi‐cine,external application of traditional Chinese medicine,fumigation,acupuncture therapy,massage therapy for regulating tendons,and targeted penetration therapy of tra‐ditional Chinese medicine.According to relevant literature,traditional Chinese medicine can significantly alleviate knee joint symptoms and improve knee joint function in patients with knee osteoarthritis,which is of great significance for the prevention and treatment of knee osteoarthritis.This article provides a review of the research progress in the prevention and treatment of KOA using traditional Chinese medicine in recent years.

含立构复合晶体的聚己内酯形状记忆弹性体的制备及性能

以聚己内酯(PCL)、左旋丙交酯(LLA)、右旋丙交酯(DLA)为原料,以辛酸亚锡(Sn(Oct)2)为催化剂,合成了不同LA含量的P(LLA-b-CL)和P(DLA-b-CL)嵌段共聚物。用凝胶渗透色谱、核磁共振等研究了嵌段共聚物的组成与结构。将2种嵌段共聚物按一定比例溶液共混,并通过流延法得到PCL基形状记忆弹性体薄膜,研究了其结晶性能、晶体形态、力学性能及形状记忆性能。结果表明,随LA添加量增大,弹性体薄膜中的PLLA与PDLA形成的立构复合(SC)晶体结晶度增大;同时,PLA非晶区含量提高,70℃拉伸时PLA链段产生滑移,形状回复率降低。因此,弹性体中SC晶体的结晶度越高,形状回复率越高,形状回复率最佳可达93.54%。

Bright 547-dimensional Hilbert-space entangled resource in 28-pair modes biphoton frequency comb from a reconfigurable silicon microring resonator

High-dimensional entanglement provides valuable resources for quantum technologies,including quantum communication,quantum optical coherence tomography,and quantum computing.Obtaining a high brightness and dimensional entanglement source has significant value.Here we utilize a tunable asymmetric Mach–Zehnder interferometer coupled silicon microring resonator with 100 GHz free spectral range to achieve this goal.With the strategy of the tunable coupler,the dynamical and extensive tuning range of quality factors of the microring can be obtained,and then the biphoton pair generation rate can be optimized.By selecting and characterizing 28 pairs from a more than 30-pair modes biphoton frequency comb,we obtain a Schmidt number of at least 23.4 and on-chip pair generation rate of 19.9 MHz/m W;under a low on-chip pump power,which corresponds to 547 dimensions Hilbert space in frequency freedom.These results will prompt the wide applications of quantum frequency comb and boost the further large density and scalable on-chip quantum information processing.

Heralded path-entangled NOON states generation from a reconfigurable photonic chip

Maximal multi-photon entangled states,known as NOON states,play an essential role in quantum metrology.With the number of photons growing,NOON states are becoming increasingly powerful and advantageous for obtaining supersensitive and super-resolved measurements.In this paper,we propose a universal scheme for generating three-and four-photon path-entangled NOON states on a reconfigurable photonic chip via photons subtracted from pairs and detected by heralding counters.Our method is postselection free,enabling phase supersensitive measurements and sensing at the Heisenberg limit.Our NOON-state generator allows for integration of quantum light sources as well as practical and portable precision phase-related measurements.

Boosting the dimensionality of frequency entanglement using a reconfigurable microring resonator

Integrated quantum frequency combs(QFCs)based on microring resonators supplies as an essential resource for expanding the Hilbert-space dimensionality for high-dimensional quantum computing and information processing.In this work,we propose and demonstrate a reconfigurable ring resonator with tunable quality factors to efficiently increase the dimensionality of frequency entanglement,simultaneously,ensuring a high on-chip pair generation rate(PGR)and coincidence-to-accidental ratio(CAR).Our method exploits the asymmetric Mach-Zehnder interferometer instead of the traditional straight waveguide as the coupler of resonators which offer a tunable external coupling coefficient to modulate the quality factor to enlarge the QFCs’bandwidth and thus increase the dimensionality of frequency entanglement.We measured the QFCs’joint spectral intensity of 28 frequency pairs under various quality factors ranging from 16.6×10^(4) to 3.4×10^(4).Meanwhile,the measured Schmidt number increased from 11.01 to 24.77,denoting a huge expansion of the Hilbert-space dimensionality from 121 to a record number of 613 dimensions,which agrees well with our theoretical calculations.In addition,the PGR and CAR-another two key parameters for high-quality QFCs-were all measured under different quality factors to verify that our method can significantly increase the Schmidt number and CAR while maintaining a high PGR.In fact,bright QFCs with a total PGR of 4.3 MHz under a 0.48 mW pump power and a mean CAR of 1578 were simultaneously obtained at the highest Schmidt number.This method is widely applicable to other material-based ring resonators and can act as a general solution for high-dimensional QFCs.

RELIABILITY INDICES OF DISCRETE-TIME Geo^X/G/1 QUEUEING SYSTEM WITH UNRELIABLE SERVICE STATION AND MULTIPLE ADAPTIVE DELAYED VACATIONS

这篇论文从可靠性研究的观点与不可靠的加油站和多重适应推迟的假期认为排队的分离时间的 GeoX/G/1 是模型。后面的问题将被讨论：1 ) 服务者在在时间 n 的一个概括忙时期的概率；2 ) 加油站在在时间 n 的失败的概率，即，加油站的短暂 unavailability，和加油站的稳定的州的 unavailability；3 ) 加油站失败的期望的数字在时间间隔期间(0， n ] ，并且加油站的稳定的州的失败频率；4 ) 加油站故障在的期望的数字一概括的服务者忙碌时期。最后，作者证明有不可靠的加油站的一些普通分离时间的排队模型是在这篇论文讨论的模型的特殊情况。

Geom/G_1,G_2/1/1 REPAIRABLE ERLANG LOSS SYSTEM WITH CATASTROPHE AND SECOND OPTIONAL SERVICE

这份报纸学习一个单身的服务器有 Bernoulli 到达过程和没有等待的空格的分离时间的厄兰损失系统。在系统的服务者被假定提供服务的二种不同类型，也就是必要、可选的服务，到顾客。在系统的操作期间，大祸的到达将毁坏系统并且同时劝诱顾客立即离开系统。用一种新类型分离增补可变技术，作者获得排队系统的一些性能特征包括不变的可获得性和系统的失败频率，为是闲散的服务器，的不变的可能性忙碌，故障和系统等等的损失概率。由数字例子，最后，作者在几项表演措施上学习系统参数的影响。

Recursive Solution of Queue Length Distribution for Geo/G/1 Queue with Delayed Min(N, D)-Policy

In this paper we consider a discrete-time Geo/G/1 queue with delayed Min(N, D)-policy.Using renewal process theory, total probability decomposition technique and z-transform, we study the transient and equilibrium properties of the queue length from an arbitrary initial state, and obtain both the recursive expressions of the transient state queue length distribution and the steady state queue length distribution at arbitrary time epoch n+. Furthermore, we derive the important relations between equilibrium queue length distributions at different time epochs n-, n and n+. Finally, we give some numerical examples about capacity decision in queueing systems to demonstrate the application of the analytical results reported in this paper.

Experimental demonstration of quantum transport enhancement using time-reversal symmetry breaking on a silicon photonic chip

The continuous-time quantum walk is a basic model for studying quantum transport and developing quantum-enhanced algorithms. Recent studies show that by introducing a phase into the standard continuous-time quantum walk model, the time-reversal symmetry can be broken without changing the Hermitian property of the Hamiltonian. The time-reversal symmetry breaking quantum walk shows advantages in quantum transport, such as perfect state transfer, directional control, transport speedup, and quantum transport efficiency enhancement. In this work, we implement the time-reversal symmetry breaking quantum walks on a reconfigurable silicon photonic chip and demonstrate the enhancement introduced by breaking time-reversal symmetry. Perfect state transfer on a three-site ring, a quantum switch implemented on a six-site graph, and transport speedup using a linear chain of triangles are demonstrated with high fidelity. Time-reversal asymmetry has also been used in a simplified light-harvesting model,implying the potential of time-reversal symmetry breaking in photosynthesis investigations.