Vesicular drug delivery systems(DDSs)are important in modern medicine,especially for cancer theranostics[1].Traditional vesicular DDSs,such as liposomes and polymersomes,have received a lot of attention owing to excel...Vesicular drug delivery systems(DDSs)are important in modern medicine,especially for cancer theranostics[1].Traditional vesicular DDSs,such as liposomes and polymersomes,have received a lot of attention owing to excellent delivery capabilities.However,due to the instability,poor biodegradation and long-term immunotoxicity,their clinical applications are hindered.Therefore,it is urgent to develop novel vesicular DDSs with multiple therapeutic functions,simple preparation and low side effects[2].展开更多
Cancer drug resistance has become one of the main challenges for the failure of chemotherapy,greatly limiting the selection and use of anticancer drugs and dashing the hopes of cancer patients.The emergence of supramo...Cancer drug resistance has become one of the main challenges for the failure of chemotherapy,greatly limiting the selection and use of anticancer drugs and dashing the hopes of cancer patients.The emergence of supramolecular host-guest nanosystems has brought the field of supramolecular chemistry into the nanoworld,providing a potential solution to this challenge.Compared with conventional chemotherapeutic platforms,supramolecular host-guest nanosystems can reverse cancer drug resistance by increasing drug uptake,reducing drug efflux,activating drugs,and inhibiting DNA repair.Herein,we summarize the research progress of supramolecular host-guest nanosystems for overcoming cancer drug resistance and discuss the future research direction in this field.It is hoped that this review will provide more positive references for overcoming cancer drug resistance and promoting the development of supramolecular host-guest nanosystems.展开更多
Urban lake ecosystems are significant for social development,but currently we know little about the geographical distribution of algal community in urban lakes at a large-scale.In this study,we investigated the algal ...Urban lake ecosystems are significant for social development,but currently we know little about the geographical distribution of algal community in urban lakes at a large-scale.In this study,we investigated the algal community structure in different areas of urban lakes in China and evaluated the influence of water quality parameters and geographical location on the algal community.The results showed that obvious differences in water quality and algal communities were observed among urban lakes in different geographical areas.Chlorophyta was the dominant phylum,followed by cyanobacteria in all areas.The network analysis indicated that algal community composition in urban lakes of the western and southern area showed more variations than the eastern and northern areas,respectively.Redundancy analysis and structural equation model revealed that nutrients and p H were dominant environmental factors that affected the algal community,and they showed higher influence than that of iron,manganese and COD Mn concentration.Importantly,algal community and density exhibited longitude and latitude relationship.In general,these results provided an ecological insight into large-scale geographical distributions of algal community in urban lakes,thereby having potential applications for management of the lakes.展开更多
Sandy-conglomerate reservoir has gradually become a major target of oil and gas exploration.Complex diagenetic process and diagenetic fluid play a significant role in affecting reservoir heterogeneity.Carbonate cement...Sandy-conglomerate reservoir has gradually become a major target of oil and gas exploration.Complex diagenetic process and diagenetic fluid play a significant role in affecting reservoir heterogeneity.Carbonate cements form at various stages of the diagenesis process and record various geological fluid information.Recently,one-billion-ton sandy conglomerate oil field was exposed in Triassic Baikouquan Formation,Mahu sag,Junggar Basin.Therefore,an integrated study applying casting thin sections,cathodeluminescence,fluorescence,carbon and oxygen stable isotopes,electronic probe microanalysis and aqueous fluid inclusions measurements was performed in order to identify the types of carbonate mineral and its representative diagenetic environment and discuss the influences of different CO_(2) injections on reservoir quality.The main findings are as follows:The reservoir is mainly composed of 70.33%conglomerate and 16.06%coarse-grained sandstone.They are characterized by low compositional maturity and abundant lithic debris.Four types carbonate cements are identified according to the petrological and geochemical characteristics,including two types of Mn-rich calcite,ferroan calcite,siderite and dawsonite.They display an unusual broad spectrum ofδ^(13)C values(-54.99‰to+8.8‰),suggesting both organic and inorganic CO_(2) injections.The δ^(13)C values of siderite are close to 0,and its formation is related to meteoric water.Theδ^(13)C values of ferroan calcite and the occurrence of dawsonite indicate the trace of inorganic mantle-derived magmatic fluids.Theδ^(13)C values and trace elements of Mn-rich calcite record the information of hydrocarbon-bearing fluids.The fluid inclusions measurement data and reservoir properties and oil-test data show that the oil content of reservoir is not only affected by the formation time of different cements,but also by the relative content of dissolution and cementation.For these reservoirs altered by carbonate cements,it does not cause poor oil-bearing due to blockage of secondary minerals.展开更多
文摘Vesicular drug delivery systems(DDSs)are important in modern medicine,especially for cancer theranostics[1].Traditional vesicular DDSs,such as liposomes and polymersomes,have received a lot of attention owing to excellent delivery capabilities.However,due to the instability,poor biodegradation and long-term immunotoxicity,their clinical applications are hindered.Therefore,it is urgent to develop novel vesicular DDSs with multiple therapeutic functions,simple preparation and low side effects[2].
基金We thank the National Natural Science Foundation of China(22101043)the Fundamental Research Funds for the Central Universities(N2205013,N232410019)+1 种基金the Open Fund of Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications(2022A07)Northeastern University for financial support.
文摘Cancer drug resistance has become one of the main challenges for the failure of chemotherapy,greatly limiting the selection and use of anticancer drugs and dashing the hopes of cancer patients.The emergence of supramolecular host-guest nanosystems has brought the field of supramolecular chemistry into the nanoworld,providing a potential solution to this challenge.Compared with conventional chemotherapeutic platforms,supramolecular host-guest nanosystems can reverse cancer drug resistance by increasing drug uptake,reducing drug efflux,activating drugs,and inhibiting DNA repair.Herein,we summarize the research progress of supramolecular host-guest nanosystems for overcoming cancer drug resistance and discuss the future research direction in this field.It is hoped that this review will provide more positive references for overcoming cancer drug resistance and promoting the development of supramolecular host-guest nanosystems.
基金the National Natural Science Foundation of China(No.51978561)the International Science and Technology Cooperation Program in Shaanxi Province(No.2018kw-011)Shaanxi Provincial Key Research and Development Projects(Nos.2019ZDLSF06-01 and 2019ZDLSF06-02).
文摘Urban lake ecosystems are significant for social development,but currently we know little about the geographical distribution of algal community in urban lakes at a large-scale.In this study,we investigated the algal community structure in different areas of urban lakes in China and evaluated the influence of water quality parameters and geographical location on the algal community.The results showed that obvious differences in water quality and algal communities were observed among urban lakes in different geographical areas.Chlorophyta was the dominant phylum,followed by cyanobacteria in all areas.The network analysis indicated that algal community composition in urban lakes of the western and southern area showed more variations than the eastern and northern areas,respectively.Redundancy analysis and structural equation model revealed that nutrients and p H were dominant environmental factors that affected the algal community,and they showed higher influence than that of iron,manganese and COD Mn concentration.Importantly,algal community and density exhibited longitude and latitude relationship.In general,these results provided an ecological insight into large-scale geographical distributions of algal community in urban lakes,thereby having potential applications for management of the lakes.
基金supported by the National Natural Science Foundation of China(Nos.U1762217,41702141)the Science and Technology Project of China National Petroleum Corporation(No.2016B-03).
文摘Sandy-conglomerate reservoir has gradually become a major target of oil and gas exploration.Complex diagenetic process and diagenetic fluid play a significant role in affecting reservoir heterogeneity.Carbonate cements form at various stages of the diagenesis process and record various geological fluid information.Recently,one-billion-ton sandy conglomerate oil field was exposed in Triassic Baikouquan Formation,Mahu sag,Junggar Basin.Therefore,an integrated study applying casting thin sections,cathodeluminescence,fluorescence,carbon and oxygen stable isotopes,electronic probe microanalysis and aqueous fluid inclusions measurements was performed in order to identify the types of carbonate mineral and its representative diagenetic environment and discuss the influences of different CO_(2) injections on reservoir quality.The main findings are as follows:The reservoir is mainly composed of 70.33%conglomerate and 16.06%coarse-grained sandstone.They are characterized by low compositional maturity and abundant lithic debris.Four types carbonate cements are identified according to the petrological and geochemical characteristics,including two types of Mn-rich calcite,ferroan calcite,siderite and dawsonite.They display an unusual broad spectrum ofδ^(13)C values(-54.99‰to+8.8‰),suggesting both organic and inorganic CO_(2) injections.The δ^(13)C values of siderite are close to 0,and its formation is related to meteoric water.Theδ^(13)C values of ferroan calcite and the occurrence of dawsonite indicate the trace of inorganic mantle-derived magmatic fluids.Theδ^(13)C values and trace elements of Mn-rich calcite record the information of hydrocarbon-bearing fluids.The fluid inclusions measurement data and reservoir properties and oil-test data show that the oil content of reservoir is not only affected by the formation time of different cements,but also by the relative content of dissolution and cementation.For these reservoirs altered by carbonate cements,it does not cause poor oil-bearing due to blockage of secondary minerals.
