In this paper,we apply the three circle type method and a Hardy type inequality to a nonlinear Dirac type equation on surfaces,and provide alternative proofs to the energy quantization results.
Idiopathic pulmonary fibrosis(IPF)is a lethal progressive fibrotic lung disease.The development of IPF involves different molecular and cellular processes,and recent studies indicate that lactate plays a significant r...Idiopathic pulmonary fibrosis(IPF)is a lethal progressive fibrotic lung disease.The development of IPF involves different molecular and cellular processes,and recent studies indicate that lactate plays a significant role in promoting the progression of the disease.Nevertheless,the mechanism by which lactate metabolism is regulated and the downstream effects remain unclear.The molecular chaperone CCT6A performs multiple functions in a variety of biological processes.Our research has identified a potential association between CCT6A and serum lactate levels in IPF patients.Herein,we found that CCT6A was highly expressed in type 2 alveolar epithelial cells(AEC2s)of fibrotic lung tissues and correlated with disease severity.Lactate increases the accumulation of lipid droplets in epithelial cells.CCT6A inhibits lipid synthesis by blocking the production of lactate in AEC2s and alleviates bleomycin-induced pulmonary fibrosis in mice.In addition,our results revealed that CCT6A blocks HIF-1α-mediated lactate production by driving the VHL-dependent ubiquitination and degradation of HIF-1αand further inhibits lipid accumulation in fibrotic lungs.In conclusion,we propose that there is a pivotal regulatory role of CCT6A in lactate metabolism in pulmonary fibrosis,and strategies aimed at targeting these key molecules could represent potential therapeutic approaches for pulmonary fibrosis.展开更多
Regenerative medicine(RM)is one of the most promising disciplines for advancements in modern medicine,and regenerative ophthalmology(RO)is one of the most active fields of regenerative medicine.This review aims to pro...Regenerative medicine(RM)is one of the most promising disciplines for advancements in modern medicine,and regenerative ophthalmology(RO)is one of the most active fields of regenerative medicine.This review aims to provide an overview of regenerative ophthalmology,including the range of tools and materials being used,and to describe its application in ophthalmologic subspecialties,with the exception of surgical implantation of artificial tissues or organs(e.g.,contact lens,artificial cornea,intraocular lens,artificial retina,and bionic eyes)due to space limitations.In addition,current challenges and limitations of regenerative ophthalmology are discussed and future directions are highlighted.展开更多
Two azobenzene compounds,Disperse Red 1(DR1)and 4-aminoazobenzene(Aazo),were separately linked to poly(acrylic acid)(PAA)side chains to form PAA-DR1 and PAA-Aazo,which were then associated with poly(ethylene oxide)(PE...Two azobenzene compounds,Disperse Red 1(DR1)and 4-aminoazobenzene(Aazo),were separately linked to poly(acrylic acid)(PAA)side chains to form PAA-DR1 and PAA-Aazo,which were then associated with poly(ethylene oxide)(PEO)to produce hydrogen-bonded polymer complex fibers.After UV irradiation,the initial modulus and yielding strength of PAA-Aazo/PEO fiber were both increased tremendously,while the mechanical properties of PAA-DR1/PEO fiber only slightly changed.After drawn and dried in vacuum,PAA-DR1/PEO and PAA-Aazo/PEO fibers with an extended length exhibited a contraction of 20%and 25%under UV irradiation,showing potential for photo-actuation.展开更多
A small proportion of mononuclear diploid cardiomyocytes(MNDCMs),with regeneration potential,could persist in adult mammalian heart.However,the heterogeneity of MNDCMs and changes during development remains to be illu...A small proportion of mononuclear diploid cardiomyocytes(MNDCMs),with regeneration potential,could persist in adult mammalian heart.However,the heterogeneity of MNDCMs and changes during development remains to be illuminated.To this end,12645 cardiac cells were generated from embryonic day 17.5 and postnatal days 2 and 8 mice by single-cell RNA sequencing.Three cardiac developmental paths were identified:two switching to cardiomyocytes(CM)maturation with close CM–fibroblast(FB)communications and one maintaining MNDCM status with least CM–FB communications.Proliferative MNDCMs having interactions with macrophages and non-proliferative MNDCMs(non-pMNDCMs)with minimal cell–cell communications were identified in the third path.The non-pMNDCMs possessed distinct properties:the lowest mitochondrial metabolisms,the highest glycolysis,and high expression of Myl4 and Tnni1.Single-nucleus RNA sequencing and immunohistochemical staining further proved that the Myl4^(+)Tnni1+MNDCMs persisted in embryonic and adult hearts.These MNDCMs were mapped to the heart by integrating the spatial and single-cell transcriptomic data.In conclusion,a novel non-pMNDCM subpopulation with minimal cell–cell communications was unveiled,highlighting the importance of microenvironment contribution to CM fate during maturation.These findings could improve the understanding of MNDCM heterogeneity and cardiac development,thus providing new clues for approaches to effective cardiac regeneration.展开更多
In this paper, we study the blow-up analysis of extrinsic biharmonic maps from a general Riemannian4-manifold into a compact Riemannian manifold. We prove that the energy identity and the no neck property hold with th...In this paper, we study the blow-up analysis of extrinsic biharmonic maps from a general Riemannian4-manifold into a compact Riemannian manifold. We prove that the energy identity and the no neck property hold with the aid of a Pohozaev identity over general Riemannian manifolds.展开更多
For a sequence of approximate Dirac-harmonic maps from a closed spin Riemann surface into a stationary Lorentzian manifold with uniformly bounded energy,we study the blow-up analysis and show that the Lorentzian energ...For a sequence of approximate Dirac-harmonic maps from a closed spin Riemann surface into a stationary Lorentzian manifold with uniformly bounded energy,we study the blow-up analysis and show that the Lorentzian energy identity holds.Moreover,when the targets are static Lorentzian manifolds,we prove the positive energy identity and the no neck property.展开更多
基金supported in part by the Innovation Program of Shanghai Municipal Education Commission(2021-01-07-00-02-E00087)the National Natural Science Foundation of China(12171314)+2 种基金the Shanghai Frontier Science Center of Modern Analysispartially supported by STU Scientific Research Initiation Grant(NTF23034T)supported in part by the National Natural Science Foundation of China(12101255)。
文摘In this paper,we apply the three circle type method and a Hardy type inequality to a nonlinear Dirac type equation on surfaces,and provide alternative proofs to the energy quantization results.
基金This work was supported by grants from the Ministry of Science and Technology of the People’s Republic of China(2019YFE0119500)the State Innovation Base for Pulmonary Fibrosis(111 Project)+1 种基金the Key R&D Program of Henan Province(231111310400)Henan Project of Science and Technology(232102521025,GZS2023008,and 232102310067).
文摘Idiopathic pulmonary fibrosis(IPF)is a lethal progressive fibrotic lung disease.The development of IPF involves different molecular and cellular processes,and recent studies indicate that lactate plays a significant role in promoting the progression of the disease.Nevertheless,the mechanism by which lactate metabolism is regulated and the downstream effects remain unclear.The molecular chaperone CCT6A performs multiple functions in a variety of biological processes.Our research has identified a potential association between CCT6A and serum lactate levels in IPF patients.Herein,we found that CCT6A was highly expressed in type 2 alveolar epithelial cells(AEC2s)of fibrotic lung tissues and correlated with disease severity.Lactate increases the accumulation of lipid droplets in epithelial cells.CCT6A inhibits lipid synthesis by blocking the production of lactate in AEC2s and alleviates bleomycin-induced pulmonary fibrosis in mice.In addition,our results revealed that CCT6A blocks HIF-1α-mediated lactate production by driving the VHL-dependent ubiquitination and degradation of HIF-1αand further inhibits lipid accumulation in fibrotic lungs.In conclusion,we propose that there is a pivotal regulatory role of CCT6A in lactate metabolism in pulmonary fibrosis,and strategies aimed at targeting these key molecules could represent potential therapeutic approaches for pulmonary fibrosis.
基金Supported by a grant from the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA16040201).
文摘Regenerative medicine(RM)is one of the most promising disciplines for advancements in modern medicine,and regenerative ophthalmology(RO)is one of the most active fields of regenerative medicine.This review aims to provide an overview of regenerative ophthalmology,including the range of tools and materials being used,and to describe its application in ophthalmologic subspecialties,with the exception of surgical implantation of artificial tissues or organs(e.g.,contact lens,artificial cornea,intraocular lens,artificial retina,and bionic eyes)due to space limitations.In addition,current challenges and limitations of regenerative ophthalmology are discussed and future directions are highlighted.
基金National Natural Science Foundation of China(No.51973029)Science and Technology Commission of Shanghai Municipality(No.20JC1414900).
文摘Two azobenzene compounds,Disperse Red 1(DR1)and 4-aminoazobenzene(Aazo),were separately linked to poly(acrylic acid)(PAA)side chains to form PAA-DR1 and PAA-Aazo,which were then associated with poly(ethylene oxide)(PEO)to produce hydrogen-bonded polymer complex fibers.After UV irradiation,the initial modulus and yielding strength of PAA-Aazo/PEO fiber were both increased tremendously,while the mechanical properties of PAA-DR1/PEO fiber only slightly changed.After drawn and dried in vacuum,PAA-DR1/PEO and PAA-Aazo/PEO fibers with an extended length exhibited a contraction of 20%and 25%under UV irradiation,showing potential for photo-actuation.
基金supported by the National Key Research and Development Program of China (No.2021YFA1101901)the Fundamental Research Funds for the Central Universities,HUST (No.2021GCRC073).
文摘A small proportion of mononuclear diploid cardiomyocytes(MNDCMs),with regeneration potential,could persist in adult mammalian heart.However,the heterogeneity of MNDCMs and changes during development remains to be illuminated.To this end,12645 cardiac cells were generated from embryonic day 17.5 and postnatal days 2 and 8 mice by single-cell RNA sequencing.Three cardiac developmental paths were identified:two switching to cardiomyocytes(CM)maturation with close CM–fibroblast(FB)communications and one maintaining MNDCM status with least CM–FB communications.Proliferative MNDCMs having interactions with macrophages and non-proliferative MNDCMs(non-pMNDCMs)with minimal cell–cell communications were identified in the third path.The non-pMNDCMs possessed distinct properties:the lowest mitochondrial metabolisms,the highest glycolysis,and high expression of Myl4 and Tnni1.Single-nucleus RNA sequencing and immunohistochemical staining further proved that the Myl4^(+)Tnni1+MNDCMs persisted in embryonic and adult hearts.These MNDCMs were mapped to the heart by integrating the spatial and single-cell transcriptomic data.In conclusion,a novel non-pMNDCM subpopulation with minimal cell–cell communications was unveiled,highlighting the importance of microenvironment contribution to CM fate during maturation.These findings could improve the understanding of MNDCM heterogeneity and cardiac development,thus providing new clues for approaches to effective cardiac regeneration.
基金supported by Innovation Program of Shanghai Municipal Education Commission(Grant No.2021-01-07-00-02-E00087)National Natural Science Foundation of China(Grant No.12171314)。
文摘In this paper, we study the blow-up analysis of extrinsic biharmonic maps from a general Riemannian4-manifold into a compact Riemannian manifold. We prove that the energy identity and the no neck property hold with the aid of a Pohozaev identity over general Riemannian manifolds.
基金supported by the Fundamental Research Funds for the Central Universities(Grant No.SWU119064)supported by Shanghai Frontier Research Institute for Modern Analysis(IMA-Shanghai)and Innovation Program of Shanghai Municipal Education Commission(Grant No.2021-01-07-00-02-E00087)。
文摘For a sequence of approximate Dirac-harmonic maps from a closed spin Riemann surface into a stationary Lorentzian manifold with uniformly bounded energy,we study the blow-up analysis and show that the Lorentzian energy identity holds.Moreover,when the targets are static Lorentzian manifolds,we prove the positive energy identity and the no neck property.
