Hypertension is an important global health problem that continues increase in incidence.Increased vascularstiffness has been identified as an important component of the pathogenesis of hypertension(HT).Based on theres...Hypertension is an important global health problem that continues increase in incidence.Increased vascularstiffness has been identified as an important component of the pathogenesis of hypertension(HT).Based on theresults of recent Framingham studies,it appears that aortic increased stiffness may precede hypertension suggest-ing that controlling arterial stiffness may展开更多
Contraction of small artery(diameters typically less than 250μm)vascular smooth muscle cells(VSMCs)plays a critical role in local control of blood flow and arterial pressure through its affect on vascular caliber.Spe...Contraction of small artery(diameters typically less than 250μm)vascular smooth muscle cells(VSMCs)plays a critical role in local control of blood flow and arterial pressure through its affect on vascular caliber.Specifically,contraction of small arteries in response to increased展开更多
基金supported in part by NIH grant(NIH P01HL095486),NIH grants(NIH P01HL069020,NIH R01HL093415,NIH R01HL095888),NIH grants(NIH5R01HL102472,NIH P01AG027211,NIH P01HL069020,NIH T32HL069752,NIH R01HL093481,NIHR01HL106511)
文摘Hypertension is an important global health problem that continues increase in incidence.Increased vascularstiffness has been identified as an important component of the pathogenesis of hypertension(HT).Based on theresults of recent Framingham studies,it appears that aortic increased stiffness may precede hypertension suggest-ing that controlling arterial stiffness may
文摘Contraction of small artery(diameters typically less than 250μm)vascular smooth muscle cells(VSMCs)plays a critical role in local control of blood flow and arterial pressure through its affect on vascular caliber.Specifically,contraction of small arteries in response to increased
