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Applications of a new In vivo tumor spheroid based shell-less chorioallantoic membrane 3-D model in bioengineering research
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作者 Nzola De Magalhaes Lih-Huei L.Liaw +4 位作者 michael berns Vittorio Cristini Zhongping Chen Dwayne Stupack John Lowengrub 《Journal of Biomedical Science and Engineering》 2010年第1期20-26,共7页
The chicken chorioallantoic membrane (CAM) is a classical in vivo biological model in studies of angiogenesis. Combined with the right tumor system and experimental configuration this classical model can offer new app... The chicken chorioallantoic membrane (CAM) is a classical in vivo biological model in studies of angiogenesis. Combined with the right tumor system and experimental configuration this classical model can offer new approaches to investigating tumor processes. The increase in development of biotechnolo- gical devices for cancer diagnosis and treatment, calls for more sophisticated tumor models that can easily adapt to the technology, and provide a more accurate, stable and consistent platform for rapid quantitative and qualitative analysis. As we discuss a variety of applications of this novel in vivo tumor spheroid based shell-less CAM model in biomedical engineering research, we will show that it is extremely versatile and easily adaptable to an array of biomedical applications. The model is particularly useful in quantitative studies of the progression of avascular tumors into vascularized tumors in the CAM. Its environment is more stable, flat and has a large working area and wider field of view excellent for imaging and longitudinal studies. Finally, rapid data acquisition, screening and validation of biomedical devices and therapeutics are possible with the short experimental window. 展开更多
关键词 CAM Cancer SPHEROID Optical Coherence Tomography Photodynamic Therapy Computational Modeling ANGIOGENESIS
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