Cancer remains a major cause of human mortality. The greatest barrier to cure is resistance to conventional medi- cal treatments. Therapy resistance arises through clonal evolution driven by ge- nomic instability, fos...Cancer remains a major cause of human mortality. The greatest barrier to cure is resistance to conventional medi- cal treatments. Therapy resistance arises through clonal evolution driven by ge- nomic instability, fostered by selection as therapy-sensitive ceils are eradicated. Such resistance has been attributed to al- terations in numerous cellular pathways, yet many ultimately impact the process ofmitochondrial apoptosis. The critical gatekeepers for mitochondrial apoptosis initiation are the Bcl2-homology （BH） proteins, whose interactions integrate the varied stressors a cell encounters and provide a live-or-die decision （reviewed in [1]）. As such, BH proteins are the frequent target of alterations in cancer cells during oncogenesis and tumor progression [2].展开更多
文摘Cancer remains a major cause of human mortality. The greatest barrier to cure is resistance to conventional medi- cal treatments. Therapy resistance arises through clonal evolution driven by ge- nomic instability, fostered by selection as therapy-sensitive ceils are eradicated. Such resistance has been attributed to al- terations in numerous cellular pathways, yet many ultimately impact the process ofmitochondrial apoptosis. The critical gatekeepers for mitochondrial apoptosis initiation are the Bcl2-homology （BH） proteins, whose interactions integrate the varied stressors a cell encounters and provide a live-or-die decision （reviewed in [1]）. As such, BH proteins are the frequent target of alterations in cancer cells during oncogenesis and tumor progression [2].
