Physical inactivity is very common in octogenarians.However,association between physical inactivity and mortality in octogenarians with acute coronary syndrome（ACS） remains unclear.In this study,we aimed to investig...Physical inactivity is very common in octogenarians.However,association between physical inactivity and mortality in octogenarians with acute coronary syndrome（ACS） remains unclear.In this study,we aimed to investigate association between physical inactivity and allcause mortality in octogenarian patients with ACS.In this study,we included a total of 353 hospitalized patients,aged ≥80 years,with ACS during the period of 5-year follow-up.The association between physical inactivity and all-cause mortality was analyzed by multivariable Cox aggression.Of the enrolled patients,132（37.4%） were defined as physically inactive,and 221（62.6%） as physically active.Patients with physical inactivity tended to have lower survival rate（21.2% vs.56.5%,P〈0.001） and higher mortality rate（78.8% vs.43.5%,P〈0.001）,and had a worse long-term outcome than those with physical activity（chi-square=27.52,and log rank P〈0.001）.The physical inactivity was still an independent predictor for long-term allcause mortality independent of confounders including age,prior heart failure,stroke,ejection fraction,beta-blocker,clopidogrel and percutaneous coronary intervention（HR：2.35,95% CI：1.26–4.37,P=0.007）.Our study demonstrates that physical inactivity is independently related to increased all-cause mortality in octogenarians with ACS.展开更多
Background Stem cell transplantation has been shown to have beneficial effects on dilated cardiomyopathy. However, mechanism for stem cell homing to cardiac tissue in dilated cardiomyopathy has not yet been elucidated...Background Stem cell transplantation has been shown to have beneficial effects on dilated cardiomyopathy. However, mechanism for stem cell homing to cardiac tissue in dilated cardiomyopathy has not yet been elucidated. Methods Mesenchymal stem cells were obtained from rat bone marrow, expanded in vitro, and labeled with 99mmc. Cardiomyopathy model was induced by doxorubicin in rats. 9ernTC labeled cells were infused into the left ventricles in cardiomyopathy and control rats. Sixteen hours after injection, animals were sacrificed and different tissues were harvested to measure specific radioactivity. By use of real-time polymerase chain reaction and immunohistochemistry, mRNA and protein expressions for stromal-cell-derived factor 1 in cardiac tissue were measured. Results Labeling efficiency of mesenchymal stem cells was （70.0±11.2）%. Sixteen hours after mesenchymal stem cell transplantation, the heart-to-muscle radioactivity ratio was increased significantly in cardiomyopathy hearts as compared to control hearts. Both mRNA and protein expressions of cardiomyopathy hearts as compared with control hearts. Conclusion In dilated cardiomyopathy induced by doxorubicin in heart may induce mesenchymal stem cells home to the heart. stromal-cell-derived factor 1 were up-regulated in up-regulated expression of stromal-cell-derived factor I展开更多
The two most common types of disasters caused by natural hazards in the Asia-Pacific region are floods and storms,many of them associated with typhoon(tropical cyclone)related impacts.To improve the capacity of typhoo...The two most common types of disasters caused by natural hazards in the Asia-Pacific region are floods and storms,many of them associated with typhoon(tropical cyclone)related impacts.To improve the capacity of typhoon-related disaster risk reduction so as to maximum reduce the losses of people’s life and properties,the decision makers and the public are imminently demanding the information of the targeted impact caused by typhoon.As the front line in hydro-meteorological disaster prevention and mitigation against the typhoon-related disasters,National Meteorological and Hydrological Services(NMHSs)in TC Members have recognized that forecasting impact became more important than forecasting pure causing-disaster elements.Impact-based forecasting signals an evolution from“what the weather will be”to“what the weather will do”.Many things change as impact based forecasts evolve from previous weather forecasts.To enhance impact-based typhoon forecasting,the Typhoon Committee added it into the new updated Strategic Plan 2022–2026.This paper briefed generally the concept of impact based forecasting,introduced the implementation and progresses on typhoon impact based forecasting in TC Members in recent years,and initially discussed the measures and direction for enhancement of impact-based typhoon forecasting and early warning services in future.展开更多
文摘Physical inactivity is very common in octogenarians.However,association between physical inactivity and mortality in octogenarians with acute coronary syndrome（ACS） remains unclear.In this study,we aimed to investigate association between physical inactivity and allcause mortality in octogenarian patients with ACS.In this study,we included a total of 353 hospitalized patients,aged ≥80 years,with ACS during the period of 5-year follow-up.The association between physical inactivity and all-cause mortality was analyzed by multivariable Cox aggression.Of the enrolled patients,132（37.4%） were defined as physically inactive,and 221（62.6%） as physically active.Patients with physical inactivity tended to have lower survival rate（21.2% vs.56.5%,P〈0.001） and higher mortality rate（78.8% vs.43.5%,P〈0.001）,and had a worse long-term outcome than those with physical activity（chi-square=27.52,and log rank P〈0.001）.The physical inactivity was still an independent predictor for long-term allcause mortality independent of confounders including age,prior heart failure,stroke,ejection fraction,beta-blocker,clopidogrel and percutaneous coronary intervention（HR：2.35,95% CI：1.26–4.37,P=0.007）.Our study demonstrates that physical inactivity is independently related to increased all-cause mortality in octogenarians with ACS.
基金This study was supported by the National Natural Science Foundation of China （No. 30900603）, Specialized Research Fund for the Doctoral Program of Higher Education （No. 20093234110008 and No. 20093234120008）, and Project Supported by Department of Health of Jiangsu Province （No. ZX07 200902）
文摘Background Stem cell transplantation has been shown to have beneficial effects on dilated cardiomyopathy. However, mechanism for stem cell homing to cardiac tissue in dilated cardiomyopathy has not yet been elucidated. Methods Mesenchymal stem cells were obtained from rat bone marrow, expanded in vitro, and labeled with 99mmc. Cardiomyopathy model was induced by doxorubicin in rats. 9ernTC labeled cells were infused into the left ventricles in cardiomyopathy and control rats. Sixteen hours after injection, animals were sacrificed and different tissues were harvested to measure specific radioactivity. By use of real-time polymerase chain reaction and immunohistochemistry, mRNA and protein expressions for stromal-cell-derived factor 1 in cardiac tissue were measured. Results Labeling efficiency of mesenchymal stem cells was （70.0±11.2）%. Sixteen hours after mesenchymal stem cell transplantation, the heart-to-muscle radioactivity ratio was increased significantly in cardiomyopathy hearts as compared to control hearts. Both mRNA and protein expressions of cardiomyopathy hearts as compared with control hearts. Conclusion In dilated cardiomyopathy induced by doxorubicin in heart may induce mesenchymal stem cells home to the heart. stromal-cell-derived factor 1 were up-regulated in up-regulated expression of stromal-cell-derived factor I
文摘The two most common types of disasters caused by natural hazards in the Asia-Pacific region are floods and storms,many of them associated with typhoon(tropical cyclone)related impacts.To improve the capacity of typhoon-related disaster risk reduction so as to maximum reduce the losses of people’s life and properties,the decision makers and the public are imminently demanding the information of the targeted impact caused by typhoon.As the front line in hydro-meteorological disaster prevention and mitigation against the typhoon-related disasters,National Meteorological and Hydrological Services(NMHSs)in TC Members have recognized that forecasting impact became more important than forecasting pure causing-disaster elements.Impact-based forecasting signals an evolution from“what the weather will be”to“what the weather will do”.Many things change as impact based forecasts evolve from previous weather forecasts.To enhance impact-based typhoon forecasting,the Typhoon Committee added it into the new updated Strategic Plan 2022–2026.This paper briefed generally the concept of impact based forecasting,introduced the implementation and progresses on typhoon impact based forecasting in TC Members in recent years,and initially discussed the measures and direction for enhancement of impact-based typhoon forecasting and early warning services in future.
