In a recent study published in Nature,Nobs and colleagues aimed to identify novel mechanisms that may explain why diabetes is associated with an increased susceptibility to viral respiratory infections.Their analyses ...In a recent study published in Nature,Nobs and colleagues aimed to identify novel mechanisms that may explain why diabetes is associated with an increased susceptibility to viral respiratory infections.Their analyses revealed a central role of lung dendritic cells(DC)which exhibited several functional defects induced by hyperglycaemia and consequently result in impaired antiviral immune responses.展开更多
In a recent study published in Nature Medicine,Smith and colleagues used data from 1.4 million individuals across 37 genome-wide association studies(GWAS)reflecting different genetic ancestral populations to identify ...In a recent study published in Nature Medicine,Smith and colleagues used data from 1.4 million individuals across 37 genome-wide association studies(GWAS)reflecting different genetic ancestral populations to identify 12 genetic clusters,mostly shared among the different populations,and associated the weighted sums of genetic variants of each cluster—termed as partitioned polygenic scores(pPSs)—with various lab-based,anthropometric and cardiometabolic traits.Their analyses extended previous studies on biological mechanisms linking genetics to type 2 diabetes(T2D)risk and pointed to both similarities of genetic clusters across multiple populations and differences regarding their contributions to overall T2D risk among different ethnicities.展开更多
In a recent study published in Nature Medicine,Witkowski and colleagues applied untargeted metabolomics studies in 1157 people at high risk for cardiovascular disease,comprising 22%with diabetes mellitus,followed by q...In a recent study published in Nature Medicine,Witkowski and colleagues applied untargeted metabolomics studies in 1157 people at high risk for cardiovascular disease,comprising 22%with diabetes mellitus,followed by quantitative targeted analyses to identify circulating metabolites associated with an increased cardiovascular risk.展开更多
基金supported by a grant from Horizon Europe (INTERCEPT-T2D,101095433)supported by the German Diabetes Center (DDZ),which is funded by the German Federal Ministry of Health (Berlin,Germany)+1 种基金the Ministry of Culture and Science of the state North Rhine-Westphalia (Düsseldorf,Germany)receives additional funding from the German Federal Ministry of Education and Research (BMBF)through the German Center for Diabetes Research (DZD e.V.).
文摘In a recent study published in Nature,Nobs and colleagues aimed to identify novel mechanisms that may explain why diabetes is associated with an increased susceptibility to viral respiratory infections.Their analyses revealed a central role of lung dendritic cells(DC)which exhibited several functional defects induced by hyperglycaemia and consequently result in impaired antiviral immune responses.
基金The research of the authors is supported in part by grants from the German Federal Ministry of Health(BMG),the Ministry of Culture and Science of the State North Rhine-Westphalia(MKW NRW)to the German Diabetes Center(DDZ)and the German Federal Ministry of Education and Research(BMBF)to German Center for Diabetes Research(DZD e.V.)The research of CH and MR is also supported in part by grants from the European Community(HORIZON-HLTH-2022-STAYHLTH-02-01:Panel A to the INTERCEPT-T2D consortium)The research of MR is further supported in part by the Schmutzler Stiftung and the program“Profilbildung 2020”,an initiative of the Ministry of Culture and Science of the State of North Rhine-Westphalia.The sole responsibility for the content of this publication lies with the authors.
文摘In a recent study published in Nature Medicine,Smith and colleagues used data from 1.4 million individuals across 37 genome-wide association studies(GWAS)reflecting different genetic ancestral populations to identify 12 genetic clusters,mostly shared among the different populations,and associated the weighted sums of genetic variants of each cluster—termed as partitioned polygenic scores(pPSs)—with various lab-based,anthropometric and cardiometabolic traits.Their analyses extended previous studies on biological mechanisms linking genetics to type 2 diabetes(T2D)risk and pointed to both similarities of genetic clusters across multiple populations and differences regarding their contributions to overall T2D risk among different ethnicities.
基金The authors are supported in part by the German Diabetes Center(DDZ),which is funded by the Ministry of Culture and Science of the State of Northrhine Westphalia and the German Federal Ministry of Health(BMG),by grants of the Federal Ministry for Research(BMBF)to the German Center for Diabetes Research(DZD e.V.,DZD Grant 2016)M.R.is also supported by grants from the European Funds for Regional Development(EFRE-0400191)+1 种基金the German Research Foundation(DFG,SFB 1116/2,GRK 2576)the Schmutzler-Stiftung and the European Community(HORIZON-HLTH2022-STAYHLTH-02-01:Panel A)to the INTERCEPT-T2D consortium.
文摘In a recent study published in Nature Medicine,Witkowski and colleagues applied untargeted metabolomics studies in 1157 people at high risk for cardiovascular disease,comprising 22%with diabetes mellitus,followed by quantitative targeted analyses to identify circulating metabolites associated with an increased cardiovascular risk.
