Intracellular signal transduction controlling neuronal development and survival is conveyed by second messengers that are often differentially regulated over space and time.The highly polarized morphology of neurons i...Intracellular signal transduction controlling neuronal development and survival is conveyed by second messengers that are often differentially regulated over space and time.The highly polarized morphology of neurons is conferred by a network of regulatory signaling pathways that determine axon guidance and dendrite formation.Among these,cyclic adenosine monophosphate(cAMP)is a second messenger that is critical for numerous neuronal functions and known to activate and integrate a variety of downstream pathways.In the central nervous system(CNS),cAMP-dependent signaling is involved in growth cone motility,neuronal metabolism,axon extension in vitro,neuroprotection,and survival in vivo.The complexity of cAMP-dependent neuronal physiology and function raises fundamental questions about the mechanisms determining the specificity by which cAMP can regulate these processes.展开更多
In the central nervous system（CNS）,cyclic adenosine monophosphate（cAMP）plays a critical role in numerous,often concurrent,neuronal functions including survival,growth,differentiation and synaptogenesis.
基金supported in part by National Institutes of Health Grant EY026766(to MSK)
文摘Intracellular signal transduction controlling neuronal development and survival is conveyed by second messengers that are often differentially regulated over space and time.The highly polarized morphology of neurons is conferred by a network of regulatory signaling pathways that determine axon guidance and dendrite formation.Among these,cyclic adenosine monophosphate(cAMP)is a second messenger that is critical for numerous neuronal functions and known to activate and integrate a variety of downstream pathways.In the central nervous system(CNS),cAMP-dependent signaling is involved in growth cone motility,neuronal metabolism,axon extension in vitro,neuroprotection,and survival in vivo.The complexity of cAMP-dependent neuronal physiology and function raises fundamental questions about the mechanisms determining the specificity by which cAMP can regulate these processes.
基金supported by National Eye Institute grants R01 EY022129 and EY026766 to MSK and F32 EY025915 to EGC
文摘In the central nervous system（CNS）,cyclic adenosine monophosphate（cAMP）plays a critical role in numerous,often concurrent,neuronal functions including survival,growth,differentiation and synaptogenesis.
