In a recent Cancer Cell publication,Klysz et al.investigated the impact of inosine(INO),a catabolic product of adenosine(Ado),on Chimeric Antigen Receptor(CAR)T-cell function,stemness,and exhaustion.They provided insi...In a recent Cancer Cell publication,Klysz et al.investigated the impact of inosine(INO),a catabolic product of adenosine(Ado),on Chimeric Antigen Receptor(CAR)T-cell function,stemness,and exhaustion.They provided insights into T-cell exhaustion metabolic pathways and proposed mechanisms for overcoming it through metabolic reprogramming.展开更多
基金a grant(CONAN,16GW0328K)provided by the Federal Ministry of Education and Research(BMBF).
文摘In a recent Cancer Cell publication,Klysz et al.investigated the impact of inosine(INO),a catabolic product of adenosine(Ado),on Chimeric Antigen Receptor(CAR)T-cell function,stemness,and exhaustion.They provided insights into T-cell exhaustion metabolic pathways and proposed mechanisms for overcoming it through metabolic reprogramming.
