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Necrotizing enterocolitis: A multifactorial disease with no cure 被引量:20
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作者 Kareena L Schnabl John E Van Aerde +1 位作者 Alan BR thomson michael t clandinin 《World Journal of Gastroenterology》 SCIE CAS CSCD 2008年第14期2142-2161,共20页
Necrotizing enterocolitis is an inflammatory bowel disease of neonates with significant morbidity and mortality in preterm infants. Due to the multifactorial nature o the disease and limitations in disease models, ear... Necrotizing enterocolitis is an inflammatory bowel disease of neonates with significant morbidity and mortality in preterm infants. Due to the multifactorial nature o the disease and limitations in disease models, early diagnosis remains challenging and the pathogenesis elusive. Although preterm birth, hypoxic-ischemic events formula feeding, and abnormal bacteria colonization are established risk factors, the role of genetics and vasoactive/inflammatory mediators is unclear Consequently, treatments do not target the specific underlying disease processes and are symptomatic and surgically invasive. Breast-feeding is the most effective preventative measure. Recent advances in the prevention of necrotizing enterocolitis have focused on bioactive nutrients and trophic factors in human milk. Developmen of new disease models including the aspect of prematurity that consistently predisposes neonates to the disease with multiple risk factors will improve our understanding of the pathogenesis and lead to discovery of innovative therapeutics. 展开更多
关键词 Necrotizing enterocolitis DIAGNOSIS PATHOGENESIS PREVENTION Disease models Vasoactive/ inflammatory mediators
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