Techniques to study brain activities have evolved dramatically,yet tremendous challenges remain in acquiring high-throughput electrophysiological recordings minimally invasively.Here,we develop an integrated neuroelec...Techniques to study brain activities have evolved dramatically,yet tremendous challenges remain in acquiring high-throughput electrophysiological recordings minimally invasively.Here,we develop an integrated neuroelectronic array that is filamentary,highdensity and flexible.Specifically,with a design of single-transistor multiplexing and current sensing,the total 256 neuroelectrodes achieve only a 2.3×0.3mm^(2)area,unprecedentedly on a flexible substrate.A single-transistor multiplexing acquisition circuit further reduces noise from the electrodes,decreases the footprint of each pixel,and potentially increases the device’s lifetime.The filamentary neuroelectronic array also integrates with a rollable contact pad design,allowing the device to be injected through a syringe,enabling potential minimally invasive array delivery.Successful acute auditory experiments in rats validate the ability of the array to record neural signals with high tone decoding accuracy.Together,these results establish soft,high-density neuroelectronic arrays as promising devices for neuroscience research and clinical applications.展开更多
基金supported by National Eye Institute award R21EY030710National Science Foundation award DMR-1905575a Samsung Global Research Outreach Award,National Science Foundation award CBET-1752274,and U01NS099697 and U01NS123668 from the National Institutes of Health.
文摘Techniques to study brain activities have evolved dramatically,yet tremendous challenges remain in acquiring high-throughput electrophysiological recordings minimally invasively.Here,we develop an integrated neuroelectronic array that is filamentary,highdensity and flexible.Specifically,with a design of single-transistor multiplexing and current sensing,the total 256 neuroelectrodes achieve only a 2.3×0.3mm^(2)area,unprecedentedly on a flexible substrate.A single-transistor multiplexing acquisition circuit further reduces noise from the electrodes,decreases the footprint of each pixel,and potentially increases the device’s lifetime.The filamentary neuroelectronic array also integrates with a rollable contact pad design,allowing the device to be injected through a syringe,enabling potential minimally invasive array delivery.Successful acute auditory experiments in rats validate the ability of the array to record neural signals with high tone decoding accuracy.Together,these results establish soft,high-density neuroelectronic arrays as promising devices for neuroscience research and clinical applications.
