化疗后前纵隔氟代脱氧葡萄糖摄取增高随访研究

目的:探讨化疗后前纵隔胸腺部位FDG摄取增高的意义。方法:回顾分析49例化疗后行FDGPET检查的肿瘤患者胸腺部位FDG摄取灶的变化情况。男性19例,女性30例;年龄5～71岁,平均27.3岁。其中26例患者之后进行PET随访,17例行CT随访,6例行PET和CT随访。平均随访时间11.3个月。结果:49例患者随访结果显示,48例PET图像上胸腺部位FDG摄取无明显增强和(或)CT图像上显示局部软组织缩小。1例患者为原发性胸腺癌患者。结论:肿瘤患者化疗后纵隔部位的三角形轻至中度FDG摄取,可能与短暂性的胸腺良性增生反应有关,不代表恶性病变。

统一通信:在经济波动时期推进商业价值

当前,经济不稳定的局面促使企业重新考量它们的成本以及在IT、语音系统方面的投入。2009年本地区的技术投入增长放缓。据IDC预测,亚太地区（包括日本）在IT方面的支出增长率将从9．5％降至5．8％。很自然地，企业的CEO在关注能够迅速带来投资回报率的重点技术项目的同时，也愈发感受到来源于精简公司运营、削减成本，从而为公司未来增长做好准备的巨大压力。然而，企业在缩减成本时却常常忽略对语音系统的充分利用，结果，

统一通信:在经济波动时期推进商业价值

当前,经济不稳定的局面促使企业重新考量它们的成本以及在IT、语音系统方面的投入。2009年本地区的技术投入增长放缓。据IDC预测,亚太地区（包括日本）在IT方面的支出增长率将从9.5%降至5．8％。

The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities

The evolutionarily conserved Wnt signaling pathway plays a central role in develop-ment and adult tissue homeostasis across species.Wnt proteins are secreted,lipid-modified signaling molecules that activate the canonical(β-catenin dependent)and non-canonical(β-catenin independent)Wnt signaling pathways.Cellular behaviors such as proliferation,differ-entiation,maturation,and proper body-axis specification are carried out by the canonical pathway,which is the best characterized of the known Wnt signaling paths.Wnt signaling has emerged as an important factor in stem cell biology and is known to affect the self-renewal of stem cells in various tissues.This includes but is not limited to embryonic,hematopoietic,mesenchymal,gut,neural,and epidermal stem cells.Wnt signaling has also been implicated in tumor cells that exhibit stem cell-like properties.Wnt signaling is crucial for bone formation and presents a potential target for the development of therapeutics for bone disorders.Not surprisingly,aberrant Wnt signaling is also associated with a wide variety of diseases,including cancer.Mutations of Wnt pathway members in cancer can lead to unchecked cell proliferation,epithelial-mesenchymal transition,and metastasis.Altogether,advances in the understand-ing of dysregulated Wnt signaling in disease have paved the way for the development of novel therapeutics that target components of the Wnt pathway.Beginning with a brief overview of the mechanisms of canonical and non-canonical Wnt,this review aims to summarize the cur-rent knowledge of Wnt signaling in stem cells,aberrations to the Wnt pathway associated with diseases,and novel therapeutics targeting the Wnt pathway in preclinical and clinical studies.

Canonical and noncanonical Wnt signaling: Multilayered mediators, signaling mechanisms and major signaling crosstalk

Wnt signaling plays a major role in regulating cell proliferation and differentiation.The Wnt ligands are a family of 19 secreted glycoproteins that mediate their signaling effects via binding to Frizzled receptors and LRP5/6 coreceptors and transducing the signal either throughβ-catenin in the canonical pathway or through a series of other proteins in the nonca-nonical pathway.Many of the individual components of both canonical and noncanonical Wnt signaling have additional functions throughout the body,establishing the complex interplay between Wnt signaling and other signaling pathways.This crosstalk between Wnt signaling and other pathways gives Wnt signaling a vital role in many cellular and organ processes.Dys-regulation of this system has been implicated in many diseases affecting a wide array of organ systems,including cancer and embryological defects,and can even cause embryonic lethality.The complexity of this system and its interacting proteins have made Wnt signaling a target for many therapeutic treatments.However,both stimulatory and inhibitory treatments come with potential risks that need to be addressed.This review synthesized much of the current knowl-edge on the Wnt signaling pathway,beginning with the history of Wnt signaling.It thoroughly described the different variants of Wnt signaling,including canonical,noncanonical Wnt/PCP,and the noncanonical Wnt/Ca2+pathway.Further description involved each of its components and their involvement in other cellular processes.Finally,this review explained the various other pathways and processes that crosstalk with Wnt signaling.

危机中的统一通信商业价值

当前,经济不稳定的局面促使企业重新考量它们的成本以及在IT、语音系统方面的投入。2009年亚太地区的技术投入明显增长放缓。据IDC预测,亚太地区(包括日本)在IT方面的支出增长率将从9.5%降至5.8%。很自然地,企业的CEO在关注能够迅速带来投资回报率的重点技术项目的同时,也愈发感受到来源于精简公司运营、削减成本,从而为公司未来增长做好准备的巨大压力。然而,企业在缩减成本时却常常忽略对语音系统的充分利用,结果造成,IT和语音系统各自为政,数据通信服务跟业务应用及通话等服务相分离。其实,如果能够尽快消除这些屏障,企业便可以最大程度地获得技术融合所带来的益处。