Objective Volume navigation (Vnav) combines real-time ultrasound (US) with previously acquired volume data from magnetic resonance imaging (MRI) data into a single display. The efficacy of Vnav for preoperative assess...Objective Volume navigation (Vnav) combines real-time ultrasound (US) with previously acquired volume data from magnetic resonance imaging (MRI) data into a single display. The efficacy of Vnav for preoperative assessment of the extent of breast cancer lesions was evaluated in the present study.Methods Twenty-nine breast cancer patients were evaluated using Vnav during second-look US or preoperative mapping. Retrospective chart review was performed. Correlation detection rates and pathological results were evaluated.Results Vnav identified lesions that were initially detected on MRI in 23 of 29 patients (79.3%). Of the 23 patients who had US correlated lesions, pathological diagnoses of the corresponding lesions were as follows: benign (n=9) and malignant (n=14).Conclusion Vnav may be a useful technique for identification of the extent of breast cancer lesions.展开更多
Aim:Triple negative breast cancer(TNBC)is known as aggressive subtype and have no identified targeted therapies.We examined the relationship of neoadjuvant chemotherapy response to genetic variations of TNBC.Methods:T...Aim:Triple negative breast cancer(TNBC)is known as aggressive subtype and have no identified targeted therapies.We examined the relationship of neoadjuvant chemotherapy response to genetic variations of TNBC.Methods:The tumors used in this study were collected from Showa University Hospital,Japan.Thirteen formalin-fixed paraffin-embedded tumors from Japanese TNBC patients who underwent neoadjuvant chemotherapy were used for analysis.Of these,eight surgically resected tumors showed progressive disease and/or recurrence after treatment(PD/REC),and biopsy tissues from five patients showing pathological complete response(pCR)were analyzed.DNA extracted from tissue sample were analyzed.The Miseq system and Trusight Tumor Sequence panel kit were used to sequence 174 amplicons over 82 exons of 26 cancer-related genes to identify genetic mutations.Results:Seven somatic non-synonymous variants were detected in three genes(FOXL2,PIK3CA,and TP53)in all five pCR patients,and six somatic non-synonymous variants in two genes(PTEN and TP53)were detected in six of eight PD/REC patients.Eight of 13 TNBC tumors were found to have TP53 pathogenic variants,in both pCR and PD/REC cases.Conclusion:Although TP53 variation was detected in both pCR and PD/REC cases,each location and type of the variant were different.We could not identify genetic mutations associated with chemotherapy response and recurrence.展开更多
文摘Objective Volume navigation (Vnav) combines real-time ultrasound (US) with previously acquired volume data from magnetic resonance imaging (MRI) data into a single display. The efficacy of Vnav for preoperative assessment of the extent of breast cancer lesions was evaluated in the present study.Methods Twenty-nine breast cancer patients were evaluated using Vnav during second-look US or preoperative mapping. Retrospective chart review was performed. Correlation detection rates and pathological results were evaluated.Results Vnav identified lesions that were initially detected on MRI in 23 of 29 patients (79.3%). Of the 23 patients who had US correlated lesions, pathological diagnoses of the corresponding lesions were as follows: benign (n=9) and malignant (n=14).Conclusion Vnav may be a useful technique for identification of the extent of breast cancer lesions.
基金This work was supported in part by a Grant-in-Aid for the High-Technology Research Center Project from the Ministry of Education,Culture,Sports,Science and Technology of Japan.
文摘Aim:Triple negative breast cancer(TNBC)is known as aggressive subtype and have no identified targeted therapies.We examined the relationship of neoadjuvant chemotherapy response to genetic variations of TNBC.Methods:The tumors used in this study were collected from Showa University Hospital,Japan.Thirteen formalin-fixed paraffin-embedded tumors from Japanese TNBC patients who underwent neoadjuvant chemotherapy were used for analysis.Of these,eight surgically resected tumors showed progressive disease and/or recurrence after treatment(PD/REC),and biopsy tissues from five patients showing pathological complete response(pCR)were analyzed.DNA extracted from tissue sample were analyzed.The Miseq system and Trusight Tumor Sequence panel kit were used to sequence 174 amplicons over 82 exons of 26 cancer-related genes to identify genetic mutations.Results:Seven somatic non-synonymous variants were detected in three genes(FOXL2,PIK3CA,and TP53)in all five pCR patients,and six somatic non-synonymous variants in two genes(PTEN and TP53)were detected in six of eight PD/REC patients.Eight of 13 TNBC tumors were found to have TP53 pathogenic variants,in both pCR and PD/REC cases.Conclusion:Although TP53 variation was detected in both pCR and PD/REC cases,each location and type of the variant were different.We could not identify genetic mutations associated with chemotherapy response and recurrence.
